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    METHOD OF MINIMIZING DEAD-PERIODS IN ORDER TO OBTAIN HARDWARE OPTIMIZED GRADIENT WAVEFORMS
    82.
    发明公开
    METHOD OF MINIMIZING DEAD-PERIODS IN ORDER TO OBTAIN HARDWARE OPTIMIZED GRADIENT WAVEFORMS 失效
    MINIMALISIERUNGSVERFAHREN对于硬件的生产进行优化DEAD期间GRADIENTWELLENFORMEN

    公开(公告)号：EP0809810A1

    公开(公告)日：1997-12-03

    申请号：EP95931684.0

    申请日：1995-09-01

    申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

    发明人： ATALAR, Ergin ,  McVEIGH, Elliot, Ross

    IPC分类号： G01V3 ,  A61B5 ,  G01R33

    CPC分类号： G01R33/4833 ,  G01R33/561

    摘要： A method of minimizing dead-periods in magnetic resonance imaging pulse sequences employs a specimen disposed within magnetic field (6), a source of RF signals (2), a receiver (8) for receiving signals from the specimen responsive to RF pulses and emitting respective output signals. A computer (12) is provided for receiving the output signals from the receiver and establishing image information which may be displayed (16). For the dead-period, the minimum and maximum phase encoding step, the scan plane gradient pulse for the slice, phase encoding and readout directions are determined and the moments contained within the dead-period waveform is determined. The values are transformed into gradient amplifier coordinates and the minimum dead-period based on the dead-period waveform is determined. The dead-period is employed in establishing a hardware optimized waveform which may be trapezoidal. The trapezoidal waveform is preferably established by for each phase encoding step determining the starting and ending gradient levels and the moments contained within the dead-period waveform using the calculated minimum dead-period.

    SECRETED AND CELL SURFACE GENES EXPRESSED IN BENIGN AND MALIGNANT COLORECTAL TUMORS
    89.
    发明授权
    SECRETED AND CELL SURFACE GENES EXPRESSED IN BENIGN AND MALIGNANT COLORECTAL TUMORS 有权
    分泌细胞表面基因所表达良性和恶性大肠肿瘤

    公开(公告)号：EP1430071B1

    公开(公告)日：2011-04-06

    申请号：EP02773302.1

    申请日：2002-09-09

    申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

    发明人： BUCKHAULTS, Phillip ,  KINZLER, Kenneth, W. ,  VOGELSTEIN, Bert

    IPC分类号： C07H21/04 ,  C12N9/48 ,  C07K14/495

    CPC分类号： C07K14/495 ,  C07K14/47 ,  C07K14/705

    摘要： Serial analysis of gene expression (SAGE) was used to identify transcripts encoding secreted or cell-surface proteins that were expressed in benign and malignant tumors of the colorectum. A total of 290,394 tags were analyzed from normal, adenomatous and cancerous colonic epithelium. Of the 21,343 different transcripts observed, 957 were found to be differentially expressed between normal and adenoma or between normal and cancer. Forty-nine transcripts were elevated ≥ 20-fold in adenomas, 40 transcripts were elevated ≥ 20-fold in cancers, and nine transcripts were elevated ≥ 20-fold in both. Product of six these nine transcripts (TGFBI, LYS, RDP, MIC-1, REGA, and DEHL) were predicted to be secreted or to reside on the cell surface and these were analyzed in more detail. The abnormal expression levels predicted by SAGE were confirmed by quantitative PCR analyses of each of these six genes. Moreover, the cell types responsible for the elevated expression were identified by in situ hybridization and by PCR analyses of epithelial cells immunoaffinity purified from primary tumors.

    Method for detecting cellular proliferative disorders
    90.
    发明公开
    Method for detecting cellular proliferative disorders 审中-公开
    Methode zur ErkennungzellulärerWachstumskrankheiten。

    公开(公告)号：EP2290105A1

    公开(公告)日：2011-03-02

    申请号：EP10011894.2

    申请日：2000-09-14

    申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

    发明人： Issa, Jean-Pierre

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C07K14/705 ,  C12Q1/6827 ,  C12Q1/6883 ,  C12Q2523/125

    摘要： A novel T-type calcium channel (CACNA1G) is provided, as are polynucleotides encoding the same. CACNA1G has been implicated in cellular proliferative disorders. More specifically, it has been observed that the methylation state of specific regions within CpG islands associated with the CACNA1G gene correlates with a number of cancerous phenotypes involving a variety of tissue and cell types. Also provided are methods for detecting cellular proliferative disorders by determining the methylation state of genes or regulatory regions associated therewith, including CACNA1G, as well as kits containing reagents for performing invention methods.

    摘要翻译： 提供了一种新型的T型钙通道（CACNA1G），以及编码它们的多核苷酸。 CACNA1G已经涉及细胞增殖性疾病。 更具体地，已经观察到，与CACNA1G基因相关联的CpG岛内的特定区域的甲基化状态与涉及多种组织和细胞类型的多种癌性表型相关。 还提供了通过确定与其相关的基因或调节区域（包括CACNA1G）的甲基化状态以及包含用于实施发明方法的试剂的试剂盒来检测细胞增殖性疾病的方法。