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公开(公告)号：EP1919904B1
公开(公告)日：2014-01-08
申请号：EP06778068.4
申请日：2006-07-28
申请人： Janssen R&D Ireland , MEDIVIR AB
发明人： RABOISSON, Pierre Jean-Marie Bernard , DE KOCK, Herman Augustinus , DORANGE, Ismet , VENDEVILLE, Sandrine Marie Helene , SURLERAUX, Dominique Louis Nestor Ghislain , TAHRI, Abdellah , SIMONNET, Yvan , VAN DE VREKEN, Wim , HU, Lili , SIMMEN, Kenneth Alan , NILSSON, Karl Magnus , SAMUELSSON, Bengt Bertil , ROSENQUIST, Åsa Annica Kristina , WALLBERG, Hans Kristian
IPC分类号： C07D401/14 , C07K5/078 , A61K31/4725 , A61P31/14
CPC分类号： C07D401/14 , C07D401/12 , C07D417/14 , C07D487/04 , C07K5/06191
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82.发明授权CRYSTALLINE FORM OF (E) 4-[[4-[[4-(2-CYANOETHENYL)-2,6-DIMETHYLPHENYL]AMINO]-2-PYRIMIDINYL]AMINO]BENZONITRILE 有权[[4 - - [[4-（2-氰基乙烯基）-2,6-二甲基苯基]氨基] -2-嘧啶基]氨基]苄腈（E）4的结晶形式
公开(公告)号：EP2175857B1
公开(公告)日：2013-09-11
申请号：EP08786055.7
申请日：2008-07-11
申请人： Janssen R&D Ireland
发明人： STOKBROEKX, Sigrid, Carl, Maria , LEYS, Carina , THEUNISSEN, Elisabeth Maria Hélène Egide Ghislaine , BAERT, Lieven Elvire Colette
IPC分类号： A61K31/505 , C07D239/48 , A61P31/18
CPC分类号： C07D239/48
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83.发明授权PROCESSES AND INTERMEDIATES FOR PREPARING A MACROCYCLIC PROTEASE INHIBITOR OF HCV 有权过程和中间产品用于生产HCV蛋白酶的抑制剂的大环
公开(公告)号：EP2382198B1
公开(公告)日：2013-07-10
申请号：EP09801447.5
申请日：2009-12-22
IPC分类号： C07D311/06 , C07D417/04 , C07D453/04
CPC分类号： C07C67/475 , C07C231/12 , C07C235/40 , C07C2601/08 , C07D307/33 , C07D417/04 , C07D453/04
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公开(公告)号：EP2005177B1
公开(公告)日：2013-07-10
申请号：EP07727885.1
申请日：2007-04-06
申请人： Janssen R&D Ireland
发明人： DAMS, Géry Karel Julia , VEREYCKEN, Inge , VAN ACKER, Koenraad Lodewijk August , GUSTIN, Emmanuel Marie Paul Ernest , VERSCHUEREN, Wim Gaston , OHAGEN, Åsa Catrine
IPC分类号： G01N33/542 , G01N33/569
CPC分类号： G01N33/56988 , G01N33/542
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公开(公告)号：EP2480220A2
公开(公告)日：2012-08-01
申请号：EP10762626.9
申请日：2010-09-22
IPC分类号： A61K9/51 , A61K9/08 , A61K31/352 , A61P31/18
CPC分类号： A61K9/0019 , A61K9/51 , A61K31/352 , A61K47/10 , A61K47/26
摘要： This invention relates to the long term treatment of HIV infection by intermittently administering a parenteral formulation comprising brecanavir at relatively long time intervals. This invention further concerns pharmaceutical compositions for parenteral administration, comprising micro- or nanoparticles of brecanavir, suspended in an aqueous pharmaceutically acceptable carrier, for the treatment and prophylaxis of HIV infection.
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86.发明授权A HOMOGENEOUS TIME RESOLVED FLUORESCENCE BASED TEST SYSTEM FOR PARAMYXOVIRIDAE 有权基于时间齐测试系统分辨荧光FOR副粘病毒
公开(公告)号：EP2092335B1
公开(公告)日：2011-10-26
申请号：EP07848070.4
申请日：2007-12-12
发明人： ROYMANS, Dirk André E. , VAN ACKER, Koenraad Lodewijk August , VEREYCKEN, Inge , DAMS, Géry Karel Julia
IPC分类号： G01N33/542 , G01N33/569 , C07K14/115
CPC分类号： G01N21/6428 , C07K14/005 , C12N2760/18522 , G01N21/6408 , G01N33/542 , G01N2021/6441 , G01N2333/135
摘要： The present invention concerns a fluorescence resonance energy transfer based high throughput test system to measure the formation of the RSV F1 six-helix bundle. In a first embodiment the current invention relates to a homogeneous time resolved fluorescence-based test system comprising a first helical polypeptide consisting essentially of the sequence of IQN57 (SEQ ID NO: 1); a second helical polypeptide consisting essentially of the sequence of C45 (SEQ ID NO: 2) wherein said IQN57 is labeled with a light emitting fluorophore and said C45 is labeled with an ultra-violet excitable fluorophore.
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87.发明授权1-[[2-AMINO-3-(SUBSTITUTED ALKYL)-3H-BENZIMIDAZOLYL]METHYL]-3-SUBTITUTED-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION 有权1 - [[2-氨基-3-（取代的烷基）-3H-苯并咪唑基〕甲基〕-3-取代-1,3-二氢 - 苯并咪唑-2-酮作为呼吸道合胞病毒的复制抑制剂
公开(公告)号：EP1896473B1
公开(公告)日：2011-10-19
申请号：EP06763808.0
申请日：2006-06-20
发明人： BONFANTI, Jean-François , MULLER, Philippe , FORTIN, Jérôme, Michel, Claude , DOUBLET, Frédéric, Marc, Maurice
IPC分类号： C07D471/04 , C07D401/14 , A61K31/437 , A61P11/00
CPC分类号： C07D471/04 , C07D401/14
摘要： Inhibitors of RSV replication of formula (I) which can be represented by formula (I) the salts and stereochemically isomeric forms thereof, wherein R is a radical of formula (a) or (b); Q is hydrogen or C1-6alkyl optionally substituted with a heterocycle or Q is C1-6alkyl substituted with both a radical -OR4 and a heterocycle; Alk is C1-6alkanediyl; X is O or S; -a1=a2-a3=a4 - is -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH- or -CH=CH-CH=N-; R1 is Ar or a heterocycle; R2 is hydrogen, C1-6alkyl, substituted C1-6alkyl, C3-7cycloalkyl; R3 is hydrogen, C1-6alkyl, cyano, aminocarbonyl, polyhaloC1-6alkyl, C2-6alkenyl or C2-6alkynyl; R4 is hydrogen or C1-6alkyl; Ar is phenyl or substituted phenyl; Het is a heterocycle; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I).
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公开(公告)号：EP2029110B1
公开(公告)日：2011-08-31
申请号：EP07729974.1
申请日：2007-06-06
IPC分类号： A61K9/16 , A61K31/505
CPC分类号： A61K9/1652
摘要： This invention relates to a process for producing a spray-dried powder comprising microcrystalline cellulose in a solid dispersion of the anti-HIV compound etravirine (TMC125) in a water-soluble polymer.
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公开(公告)号：EP1869037B1
公开(公告)日：2011-07-27
申请号：EP06708816.1
申请日：2006-03-27
发明人： SIMMEN, Kenneth Alan , CHAKRAVARTY, Sarvajit , HART, Barry , SURLERAUX, Dominique Louis Nestor Ghislain , LIN, Tse-I , LENZ, Oliver , RABOISSON, Pierre, Jean-Marie, Bernard
IPC分类号： C07D471/04 , A61K31/495 , A61P31/00
CPC分类号： C07D471/04 , A61K31/495
摘要： Fused bicyclic pyrimidine compounds having an amide-substituted pyridylamine group at C-4 of the pyrimidine of formula (I) ring are useftul in the treatment of conditions associated with HCV.
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90.发明公开
公开(公告)号：EP2341907A1
公开(公告)日：2011-07-13
申请号：EP09783155.6
申请日：2009-09-18
发明人： LIN, Tse-I , LENZ, Oliver
IPC分类号： A61K31/4709 , A61K31/7056 , A61K31/513 , A61K38/21 , A61P31/14
CPC分类号： A61K31/513 , A61K31/18 , A61K31/4709 , A61K31/7056 , A61K2300/00
摘要： The present invention relates to a synergistic combination of the compound of formula (I), or a pharmaceutically acceptable salt thereof, and the compound of formula (II), or a pharmaceutically acceptable salt thereof.
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