公开(公告)号：EP1450945B1

公开(公告)日：2007-01-03

申请号：EP02803166.4

申请日：2002-10-23

申请人： TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： TAO, Rongija ,  LAN, Yucheng ,  KACZANOWICZ, Edward ,  XU, Xiaojun

IPC分类号： B01J19/08 ,  B24B1/00 ,  C10M171/00

CPC分类号： F16F9/532 ,  C10M171/001 ,  C10N2240/20 ,  F15B21/065

摘要： A method for increasing and/or modulating the yield shear stress of an electrorheological fluid (10) includes applying a sufficient electric field to the fluid (10) to cause the formation of chains of particles, and then applying a sufficient pressure to the fluid (10) to cause thickening or aggregation of the chains. An apparatus (20) for increasing and/or modulating the transfer of force or torque between two working structures (18, 22) includes an electrorheological fluid (10) and electrodes (25, 27) through which an electric field is applied to the fluid (10) such that chains of particles are formed in the fluid (10) and, upon application of pressure to the fluid (10), the chains thicken or aggregate and improve the force or torque transmission.

公开(公告)号：EP0650378B1

公开(公告)日：2001-10-17

申请号：EP93917159.1

申请日：1993-07-14

申请人： Temple University of the Commonwealth System of Higher Education

发明人： SHAFFER, Thomas, H. ,  WOLFSON, Marla, R.

IPC分类号： A61M31/00 ,  A61M3/00

CPC分类号： A61M1/00 ,  A61F7/00 ,  A61M3/00 ,  A61M5/44 ,  A61M2202/02 ,  A61M2202/04 ,  A61M2202/0476 ,  A61M2202/0014 ,  A61M2202/0007

摘要： This invention pertains to the use of a degassed perfluorocarbon ('PFC') liquid as a method of removing gas emboli from parts of a patient's body cava. Moreover, the invention can be used as a method of imaging parts of a patient's body cava. Furthermore, the invention can also be used as a way of delivering biological agents to parts of a patient's body cava which contain or are surrounded by gas emboli and/or which are to be imaged. In this invention, a degassed PFC liquid is delivered to a region within the patient's body cava which contains gas emboli and/or which is to be imaged. If gas emboli are present, the degassed liquid is permitted to absorb at least a portion of the emboli. Thereafter, the emboli-containing liquid is removed from the patient or is used as an imaging agent. If gas emboli are not present, the site is imaged before the degassed liquid reaches atmospheric equilibrium. Thereafter, the liquid is removed from the patient. Moreover, by mixing a biological agent with the degassed PFC liquid, the mixture can be used as a way of topically treating parts within a patient's body cava. Furthermore, by regulating the temperature of the degassed liquid, it can also be used as a way of hypo- or hyperthermically treating the patient.

公开(公告)号：EP0683683B1

公开(公告)日：2000-01-12

申请号：EP93923821.8

申请日：1993-10-08

申请人： Temple University of the Commonwealth System of Higher Education

发明人： SHAFFER, Thomas, H. ,  WOLFSON, Marla, R.

IPC分类号： A61M16/00

CPC分类号： A61M16/0054 ,  A61M16/024 ,  A61M2016/1025 ,  A61M2202/0476 ,  Y10S128/913

摘要： A process is provided for controlling a ventilation procedure wherein a liquid ventilation system passes breathing liquid through at least a portion of a patient's pulmonary pathways. In this process, desired ranges for certain process parameters associated with the liquid ventilation system are established. These desired ranges are input into a central processing unit (50). Initial settings for the liquid ventilation system are then made such that the actual conditions which will initially occur during the liquid ventilation procedure fall within their respective desired ranges. Thereafter, the procedure is commenced. During the procedure, conditions are continually monitored by sensors (16, 21, 27). The CPU (50) compares the sensor readings with the desired ranges, and acts to correct any discrepancy. The CPU can trigger alarms (514).

摘要翻译： 提供了一种用于控制通气程序的过程，其中液体通气系统使呼吸液体通过患者肺通路的至少一部分。 在该过程中，建立了与液体通气系统相关联的某些工艺参数的期望范围。 这些期望的范围被输入到中央处理单元中。 然后进行液体通气系统的初始设置，使得在液体通气过程中最初发生的实际状况落入其各自的期望范围内。 此后，液体通气程序开始。 在液体通气过程中，通过适当的传感器连续监测与建立的范围有关的条件。 所监视的信息也被输入到中央处理单元。 中央处理单元被设计为将实际发生的监视条件与它们各自的期望范围进行比较，并且确定是否存在差异。 如果存在差异，则中央处理单元产生用于校正差异的信号。 这些信号可被设计成触发报警，指示操作者进行适当的调整和/或激活伺服控制的阀门网络。

公开(公告)号：EP0963553A1

公开(公告)日：1999-12-15

申请号：EP97947260.0

申请日：1997-10-14

申请人： Temple University of the Commonwealth System of Higher Education

发明人： SCHWARTZ, Cheryl, Faye

IPC分类号： G01N33

CPC分类号： G01N33/54393 ,  G01N2333/811 ,  Y10S435/962

摘要： Solid supports for solid phase immunoassays comprise polyethyleneimine-coated negatively charged polymeric materials. The combination of negatively-charged polymer support and polyehtyleneimine coating serves to eliminate nonspecific adsorption of biological molecules such as high molecular weight kininogen, which have affinity for solid surfaces and which interfere with immunoassays. The negatively charged polymeric support to which the polyethyleneimine coating is applied may advantageously comprise, for example, a carboxylate-modified styrene microparticle. Antigens or antibodies are coupled by covalent coupling agents to the polyethyleneimine coating to form solid phase immunoreagents. Immonoassays for biological molecules such as high and low molecular weight kininogen are provided.

公开(公告)号：EP0817617A1

公开(公告)日：1998-01-14

申请号：EP96909753.0

申请日：1996-03-18

申请人： TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： SPEAKER, Tully, J. ,  SULTZBAUGH, Kenneth, J.

IPC分类号： A61K9 ,  A61K47 ,  B01J13

CPC分类号： A61K9/1652 ,  A61K9/167 ,  A61K9/5036 ,  A61K9/5073

摘要： An aqueous core microcapsule has a capsular wall provided with a peptide(s) of pre-determined binding specificity(ies) appended to the surface, the wall being the reaction product of an anionic polymer or salt thereof and a polyamine, salt thereof, mixtures thereof, or mixtures thereof with monoamines. The aqueous core may contain an active ingredient(s), and be targeted for delivery to specific cell tissues. The microcapsules are provided as a composition and in a kit with instructions for use in imaging, diagnosis, therapy, vaccination, and other applications.

公开(公告)号：EP0563318B1

公开(公告)日：1997-08-13

申请号：EP92904261.2

申请日：1991-12-19

申请人： TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： LABES, Mortimer, M.

IPC分类号： G01K11/00

CPC分类号： G01K3/04 ,  G01K11/165 ,  Y10S252/962

摘要： A container (10) for a liquid crystal cumulative dosimeter including a resilient outer body (12) sealed to confine a first liquid crystal composition constituent (14) and a second liquid crystal composition constituent (16) and having at least one transparent section (20) to permit observation of the color of the confined composition, and a barrier (30, 40) contained completely within and physically unattached to the outer body for separating the first constituent from the second constituent, whereby disruption of the barrier allows the first constituent to mix with the second constituent. The barrier is formed either by encapsulating one or both of the constituents or by using air bubbles. Methods of manufacturing the various containers shown and processes of using those containers are also disclosed.

摘要翻译： 一种用于液晶累积剂量计的容器（10），其包括被密封以约束第一液晶组合物成分（14）和第二液晶合成物成分（16）并具有至少一个透明部分（20）的弹性外体（12） ）以允许观察被限定的组合物的颜色，以及完全包含在外部主体内并且物理上不与外部主体连接以将第一成分与第二成分分离的屏障（30,40），由此屏障的破坏允许第一成分 与第二种成分混合。 屏障是通过封装一种或两种成分或通过使用气泡形成的。 还公开了制造所示的各种容器的方法以及使用这些容器的方法。

公开(公告)号：EP0683683A1

公开(公告)日：1995-11-29

申请号：EP93923821.0

申请日：1993-10-08

申请人： Temple University of the Commonwealth System of Higher Education

发明人： SHAFFER, Thomas, H. ,  WOLFSON, Marla, R.

IPC分类号： A61M16

CPC分类号： A61M16/0054 ,  A61M16/024 ,  A61M2016/1025 ,  A61M2202/0476 ,  Y10S128/913

摘要： A process is provided for controlling a ventilation procedure wherein a liquid ventilation system passes breathing liquid through at least a portion of a patient's pulmonary pathways. In this process, desired ranges for certain process parameters associated with the liquid ventilation system are established. These desired ranges are input into a central processing unit (50). Initial settings for the liquid ventilation system are then made such that the actual conditions which will initially occur during the liquid ventilation procedure fall within their respective desired ranges. Thereafter, the procedure is commenced. During the procedure, conditions are continually monitored by sensors (16, 21, 27). The CPU (50) compares the sensor readings with the desired ranges, and acts to correct any discrepancy. The CPU can trigger alarms (514).

摘要翻译： 提供了一种用于控制通气程序的过程，其中液体通气系统使呼吸液体通过患者肺通路的至少一部分。 在该过程中，建立了与液体通气系统相关联的某些工艺参数的期望范围。 这些期望的范围被输入到中央处理单元中。 然后进行液体通气系统的初始设置，使得在液体通气过程中最初发生的实际状况落入其各自的期望范围内。 此后，液体通气程序开始。 在液体通气过程中，通过适当的传感器连续监测与建立的范围有关的条件。 所监视的信息也被输入到中央处理单元。 中央处理单元被设计为将实际发生的监视条件与它们各自的期望范围进行比较，并且确定是否存在差异。 如果存在差异，则中央处理单元产生用于校正差异的信号。 这些信号可被设计成触发报警，指示操作者进行适当的调整和/或激活伺服控制的阀门网络。

公开(公告)号：EP0419574B1

公开(公告)日：1995-11-08

申请号：EP89907964.4

申请日：1989-05-26

申请人： Temple University of the Commonwealth System of Higher Education

发明人： PIXLEY, Robin, A. ,  COLMAN, Robert, W.

IPC分类号： A61K39/395 ,  C07K16/36 ,  C12N15/00 ,  C12N5/02

CPC分类号： C12N9/6451 ,  A61K38/00 ,  C07K16/40 ,  C12Y304/21038

摘要： Novel hybrid cell lines produce monoclonal antibody to the light chain region of human factor XII. Three such cell lines, ATCC #HB-9703 through ATCC #HB-9704, are formed by fusing SP2/0-Ag14 myeloma cells with spleen cells from BALB/c AnSkh mice immunized with human factor XIIf. The monoclonal antibodies may be used, for example, for removing human factor XII fragments containing the factor XII light chain, from liquids, e.g. blood plasma products.

公开(公告)号：EP0668782A1

公开(公告)日：1995-08-30

申请号：EP93919965.0

申请日：1993-08-10

申请人： TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  THOMAS JEFFERSON UNIVERSITY

发明人： CALABRETTA, Bruno ,  SKORSKI, Thomasz

IPC分类号： C12N15 ,  A61K31 ,  A61K45 ,  A61K48 ,  A61P35

CPC分类号： C12N15/113 ,  A61K45/06 ,  C12N15/1135 ,  C12N2310/312 ,  C12N2310/315

摘要： Therapeutic combinations of an antisense oligonucleotide and another, non-oligonucleotide chemotherapeutic agent are provided which allows for a reduced dosage of the non-oligonucleotide agent, and hence, reduced toxicity to the host. The antisense oligonucleotide component has a nucleotide sequence complementary to at least a portion of the mRNA transcript of a target oncogene or proto-oncongene, the amplification or expression of which is associated with the particular neoplastic disease under treatment. The combination is particularly useful in treating leukemias, more particularly as a bone marrow purging agent.

公开(公告)号：EP0592529A1

公开(公告)日：1994-04-20

申请号：EP92914432.0

申请日：1992-06-15

申请人： Temple University of the Commonwealth System of Higher Education

发明人： COLMAN, Robert, W. ,  BRADFORD, Harlan, N. ,  JAMESON, Bradford, A.

IPC分类号： A61K38 ,  A61P7 ,  C07K1 ,  C07K7 ,  C07K14

CPC分类号： C07K14/8139 ,  A61K38/00 ,  C07K1/00

摘要： On décrit des analogues peptidiques synthétiques de kininogène humain dont la conformation est restreinte par l'intermédiaire d'une fixation intramoléculaire. Les peptides imitent l'activité biologique du kininogène humain en inhibant l'activité de la protéase biologiquement significative, la calpaïne. Les peptides sont conçus par l'intermédiaire d'un modèle de conformation à l'équilibre de la chaîne lourde de kininogène.

摘要翻译： 描述了其构象通过分子内结合限制的人激肽原的合成肽类似物。 这些肽通过抑制生物学上重要的蛋白酶钙蛋白酶的活性来模拟人激肽原的生物活性。 肽是通过激肽原重链的平衡构象模型设计的。