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    IMPROVED TECHNIQUES FOR MAGNETIC PARTICLE IMAGING
    82.
    发明公开
    IMPROVED TECHNIQUES FOR MAGNETIC PARTICLE IMAGING 审中-公开

    公开(公告)号：EP4270143A3

    公开(公告)日：2023-12-27

    申请号：EP23177832.5

    申请日：2009-06-23

    申请人： The Regents Of The University Of California, Berkeley

    发明人： GOODWILL, Patrick W. ,  GONOLLY, Steven M.

    IPC分类号： A61B5/05 ,  A61K49/18 ,  G01R33/02 ,  G05F1/00

    摘要： A magnetic particle imaging apparatus includes magnets [106,107] that produce a gradient magnetic field having a field free region (FFR), excitation field electromagnets [102,114] that produce a radiofrequency magnetic field within the field free region, high-Q receiving coils [112] that detect a response of magnetic particles in the field free region to the excitation field. Field translation electromagnets create a homogeneous magnetic field displacing the field-free region through the field of view (FOV) allowing the imaging region to be scanned to optimize scan time, scanning power, amplifier heating, SAR, dB/dt, and/or slew rate. Efficient multi-resolution scanning techniques are also provided. Intermodulated low and radio-frequency excitation signals are processed to produce an image of a distribution of the magnetic nanoparticles within the imaging region. A single composite image is computed using deconvolution of multiple signals at different harmonics.

    SEROLOGIC ASSAY FOR SILENT BRAIN ISCHEMIA
    87.
    发明公开
    SEROLOGIC ASSAY FOR SILENT BRAIN ISCHEMIA 审中-公开

    公开(公告)号：EP4273548A2

    公开(公告)日：2023-11-08

    申请号：EP23184303.8

    申请日：2018-02-20

    申请人： The Regents of the University of California

    发明人： HINMAN, Jason D. ,  XIAO, Guanxi

    IPC分类号： G01N33/53

    摘要： A method for detection or monitoring status of silent brain ischemia (SBI) and cerebrovascular health. The assay reagents and methods described herein provide a specific indicator of cerebral microvascular disease, enabling clinicians to identify patients at risk for the development of SBI. A method of treating a subject having silent brain ischemia and/or metabolic syndrome comprises administering to the subject aspirin therapy, blood pressure therapy, body weight management, and/or a program of diet and exercise when levels of two or more SBI markers are elevated. Described herein are molecules that are produced by cerebral endothelial cells exposed to chronic vascular risk factors including obesity, hyperlipidemia, hypertension, and glucose intolerance. These stress molecules produced by cerebral endothelial cells are detectable in the serum and serve as diagnostic indicators of brain-specific endothelial cell damage and correlate with MRI indicators of silent stroke and impaired cognitive function.