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    Erythromycin a derivatives and method for the preparation of the same
    87.
    发明公开
    Erythromycin a derivatives and method for the preparation of the same 失效
    红霉素A-Derivate和Verfahren zu ihrer Herstellung。

    公开(公告)号：EP0272110A2

    公开(公告)日：1988-06-22

    申请号：EP87311097.7

    申请日：1987-12-16

    申请人： TAISHO PHARMACEUTICAL CO. LTD

    发明人： Morimoto, Shigeo ,  Matsunaga, Tohru ,  Adachi, Takashi ,  Kashimura, Masato ,  Asaka, Toshifumi ,  Sota, Kaoru ,  Watanabe, Yoshiaki ,  Sekiuchi, Kazuto

    IPC分类号： C07H17/08

    CPC分类号： C07H17/08

    摘要： Erythromycin A derivativ es represented by the general formula
    wherein R¹ is a group of the formula R⁷CH₂- (wherein R⁷ is a hydrogen group or a lower alkyl group) or a group of the formula R⁸O- (wherein R⁸ is a lower alkyl group), R² is R⁸, a cycloalkyl group, a phenyl group or an aralkyl group, or R² and R₇ together form an alkylene group, R³ is a hydrogen atom, a lower alkyl group, a phenyl group or an aralkyl group, or R³ and R⁷ together form an alkylene group, or R² and R³ together form an alkylene group, R⁴ is a lower alkyl group, R⁵ is a substituted silyl group, and R⁶ is a hydrogen atom or R₅, are useful as intermediates for the synthesis of antibacterial agents.

    摘要翻译： 由通式表示的红霉素A衍生物，其中R 1是式R 7 CH 2 - （其中R 7是氢基或低级烷基）或一组 式R 8 O-（其中R 8为低级烷基），R 2为R 8，环烷基，苯基或芳烷基，或R 2和R 7一起 形成亚烷基，R 3是氢原子，低级烷基，苯基或芳烷基，或者R 3和R 7一起形成亚烷基，或R 2和R <3>一起形成亚烷基，R 4为低级烷基，R 5为取代甲硅烷基，R 6为氢原子或R 5，可用作合成抗菌剂的中间体 代理商。

    Stabilized pharmaceutical compositions
    88.
    发明公开
    Stabilized pharmaceutical compositions 失效
    Stabilisierte Arzneimittel。

    公开(公告)号：EP0264259A1

    公开(公告)日：1988-04-20

    申请号：EP87309038.5

    申请日：1987-10-13

    申请人： TAISHO PHARMACEUTICAL CO. LTD

    发明人： Kouchiwa, Shozo ,  Nemoto, Masami ,  Yamaguchi, Tetsuo ,  Nakazato, Atsuro

    IPC分类号： A61K31/44 ,  A61K9/20 ,  A61K47/00

    CPC分类号： A61K47/02 ,  A61K9/2009 ,  A61K31/44 ,  Y10S514/97

    摘要： Stabilized solid pharmaceutical preparations containing, as active ingredient, a 1,4-dihydropyridine derivative of formula:
    (in which R is an n -propyl group substituted at the 2-or 3-position with a nitrato group and R¹ is a 2-nitratoethyl group which may be substituted with a methyl group at the 1- or 2-position) and one or more pharmaceutical auxiliary agents, in which the composition also contains as stabilizer, one or more of sodium carbonate, sodium hydrogen carbonate, calcium carbonate and calcium hydrogen phosphate.

    摘要翻译： 稳定的固体药物制剂，其含有下式的1,4-二氢吡啶衍生物作为活性成分：其中R是在2-或3-位被硝基取代的正丙基，R 1是 >是可以在1或2位被甲基取代的2-硝基乙基）和一种或多种药物助剂，其中所述组合物还含有作为稳定剂的一种或多种碳酸钠，氢氧化钠 碳酸盐，碳酸钙和磷酸氢钙。