-
公开(公告)号：EP0322571B1
公开(公告)日：1993-02-03
申请号：EP88119814.7
申请日：1988-11-28
发明人： Sugiyama, Makoto , Ezure, Yoji , Ojima, Nobutoshi , Seto, Takashi Room 202 , Nakamura, Teruya , Itoh, Manabu
IPC分类号： C12P13/00
CPC分类号： C12P13/001 , C12P13/00 , C12R1/465 , Y10S435/826 , Y10S435/886
摘要： 2-Amino-2-deoxy-D-mannitol is not only useful as a cosmetic or as a starting material for preparing X ray contrast media, but also a useful substance having a specific activity of enhancing the yield of moranoline in the production of moranolin; it has been found that 2-amino-2-deoxy-D-mannitol can be manufactured by culturing a microorganism belonging to the genus Streptomyces and capable of producing 2-amino-2-deoxy-D-mannitol in a medium and isolating it from the obtained culture broth.
-
公开(公告)号：EP0159497B1
公开(公告)日：1991-09-11
申请号：EP85102406.7
申请日：1985-03-04
发明人： Endo, Akira
IPC分类号： C12N9/52
CPC分类号： C12N9/52 , A61K38/00 , C12R1/465 , Y10S435/826 , Y10S530/825
摘要： Disclosed herein is a novel collagenase "discolysin". It is useful for biochemical researches and the treatment of many diseases caused by collagen, such as hernia of intervertebral disc. It can be produced by culturing a discolysin-producing bacterium belonging to genus of Streptomyces in a culture medium and then collecting discolysin from the culture medium.
-
3.发明授权A process for producing an optically active 3-(3,4-dihydroxphenyl) serine and a proteced derivative thereof 失效一种生产光学活性3-（3,4-二羟基苯基）丝氨酸及其保护衍生物的方法
公开(公告)号：EP0141613B1
公开(公告)日：1989-02-01
申请号：EP84307297.6
申请日：1984-10-24
发明人： Umezawa, Hamao , Takeuchi, Tomio , Nagatsu, Toshiharu , Hamada, Masa , Iwadare, Shuichi , Matsumoto, Ikuo , Morishima, Hajime
CPC分类号： C12P13/04 , C12P41/007 , Y10S435/826 , Y10S435/886 , Y10S435/908
-
公开(公告)号：EP0159497A2
公开(公告)日：1985-10-30
申请号：EP85102406.7
申请日：1985-03-04
发明人： Endo, Akira
IPC分类号： C12N9/52
CPC分类号： C12N9/52 , A61K38/00 , C12R1/465 , Y10S435/826 , Y10S530/825
摘要： @ Disclosed herein is a novel collagenase "discolysin". It is useful for biochemical researches and the treatment of many diseases caused by collagen, such as hernia of intervertebral disc. It can be produced by culturing a discolysin-producing bacterium belonging to genus of Streptomyces in a culture medium and then collecting discolysin from the culture medium.
-
公开(公告)号：EP0954571B1
公开(公告)日：2007-08-29
申请号：EP97920679.4
申请日：1997-04-14
申请人： Novartis AG , Novartis Pharma GmbH
CPC分类号： C12N9/80 , C12P41/007 , Y10S435/826 , Y10S435/893 , Y10S435/908
摘要： The invention belongs to the field of biotechnology. It concerns a biocatalyst, i.e. a dead or living microorganism or a polypeptide, preferably in isolated form, which exhibits acylase enzymatic activity without lipase- or esterase-activity. The biocatalyst is capable of stereoselectively hydrolysing a racemic acylamide which has an aliphatic acyl residue and which is not a derivative of a natural amino acid.
-
公开(公告)号：EP0316907B1
公开(公告)日：1993-07-28
申请号：EP88119126.6
申请日：1988-11-17
申请人： SUNTORY LIMITED
CPC分类号： C07K5/0205 , Y10S435/826
-
公开(公告)号：EP0316907A3
公开(公告)日：1990-09-12
申请号：EP88119126.6
申请日：1988-11-17
申请人： SUNTORY LIMITED
CPC分类号： C07K5/0205 , Y10S435/826
摘要： Novel peptide analogues which exhibit inhibitory activity against aspartic proteinases of the general formula I:, a novel species of actinomycetous microorganism which produces said novel peptide analogues, a process for producing said novel analogues by culturing said species and a pharmaceutical composition containing said analogues.
-
8.发明公开
公开(公告)号：EP0378321A2
公开(公告)日：1990-07-18
申请号：EP90300146.9
申请日：1990-01-05
申请人： Merck & Co., Inc.
IPC分类号： C12P1/06 , C07D498/08 , A61K35/66 , A61K31/00
CPC分类号： C07D498/18 , C07H19/01 , C12P1/06 , C12R1/01 , Y10S435/826
摘要： Described is a new immunosuppressant, L-685,487, a monodemethylated rearranged derivative of L-683,590, produced under fermentation conditions utilizing the microorganism, unidentified Actinomycete (Merck Culture Collection MA 6474) ATCC No. 53828. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
摘要翻译： 描述了一种新的免疫抑制剂L-685,487，L-683,590的单甲基化重排的衍生物，其在使用微生物的发酵条件下生产，不明的放线菌（Merck Culture Collection MA 6474）ATCC No.5828。大环内酯类免疫抑制剂可用于预防人宿主 排除外来器官移植物，例如 骨髓和心脏移植。
-
公开(公告)号：EP0201039A2
公开(公告)日：1986-11-12
申请号：EP86105958.2
申请日：1986-04-30
发明人： Umezawa, Hamao , Takeuchi, Tomio , Nagatsu, Toshiharu , Hamada, Masa , Iwadare, Shuichi Banyu Pharm. Co. Ltd. , Matsumoto, Ikuo , Morishima, Hajime
IPC分类号： C12N9/78
CPC分类号： C12N9/80 , C12P13/04 , C12P41/007 , Y10S435/826 , Y10S435/886 , Y10S435/893 , Y10S435/908
摘要： L-aminoacylases S 1 and S 2 derived from actinomycetes and having physicochemical characteristics such that it is a L-aminoacylase which acts on a N-acyl-L-amino acid to give a L-amino acid, its substrate profile is wide, and it acts not only on a N-acyl derivative of a natural L-amino acid, but also on a N-acyl derivative of a synthetic L-amino acid, while it does not act on a N-acyl-D-amino acid, a DL-N-acetyl-a-methylbenzylamine and a N-acetyl-D-glucosamine, etc.
摘要翻译： 来源于放线菌的L-氨基酰化酶S1和S2具有物理化学特性，使得它是作用于N-酰基-L-氨基酸而产生L-氨基酸的L-酰化氨基酸，其底物分布宽， 不仅在天然L-氨基酸的N-酰基衍生物上，而且在合成L-氨基酸的N-酰基衍生物上，虽然它不作用于N-酰基-D-氨基酸，DL -N-乙酰-α-甲基苄胺和N-乙酰-D-葡糖胺等
-
10.发明公开2-Amino-1,9-dihydro-6H-purin-6-one-7-oxide, the pharmaceutically acceptable salts and a process for the production thereof 失效2-氨基-1,9-二氢-6H-嘌呤-6-酮-7-氧化物，药用可接受的盐及其生产方法
公开(公告)号：EP0136923A3
公开(公告)日：1986-02-05
申请号：EP84306794
申请日：1984-10-05
发明人： Tunac, Josephino Ballesteros , Hokanson, Gerard Clifford , Kern, Donald L. , French, James Clark
IPC分类号： C07D473/18 , C12P17/18
CPC分类号： C07D473/18 , C12P17/182 , C12R1/465 , Y10S435/826
摘要： A purified isolate of an actinomycete identified as ATCC 39364 is capable of producing the anti-microbial/antitumor compound 2-amino-1,9-dihydro-6H-purin-6-one-7-oxide. 2-Amino-1,9-dihydro-6H-purin-6-one-7-oxide is produced by cultivating isolate ATCC 39364 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial amount of the compound is produced and thereafter isolating the compound. The antibiotic/antitumor compound 2-amino-1,9-dihydro-6H-purin-6-one-7-oxide and pharmaceutical compositions comprising this compound or one of its pharmaceutically acceptable salts together with a pharmaceutically acceptable carrier are also disclosed.
-
-
-
-
-
-
-
-
-
搜索结果
31 条记录 (耗时 0.01 秒)
