SYRINGE WITH TWO-STAGE SEALING PRESSURE
    84.
    发明公开
    SYRINGE WITH TWO-STAGE SEALING PRESSURE 审中-公开
    。ZE。。。。。。。。。

    公开(公告)号:EP2956191A1

    公开(公告)日:2015-12-23

    申请号:EP13714114.9

    申请日:2013-03-14

    申请人: AbbVie Inc.

    摘要: A syringe includes a barrel, a plunger, and a sealing member creating a seal between the plunger and the barrel. The barrel includes a first portion with a first inner diameter and a second portion with a second inner diameter that is larger than the first inner diameter. The sealing member engages the first portion of the barrel to give rise to a first contact pressure when the barrel is filled with product. The first contact pressure is sufficient to maintain a gas-tight seal over the expected temperature ranges -25 DEG C to 40 DEG C. A first force is applied to the plunger to overcome the first contact pressure and move the plunger out of the first portion and into the second portion to dispense product. The sealing member engages the second portion of the barrel to give rise to a second contact pressure that is lower than the first contact pressure. A second force lower than the first force is sufficient to overcome the second contact pressure and move the plunger in the second portion to continue dispensing product. The syringe may include a restraining element for accommodating expansion of the product during freezing.

    摘要翻译: 注射器包括筒体,柱塞和在柱塞和筒体之间产生密封的密封构件。 枪管包括具有第一内径的第一部分和具有大于第一内径的第二内径的第二部分。 密封构件与筒体的第一部分接合以在桶体填充产品时产生第一接触压力。 第一接触压力足以在-25℃至40℃的预期温度范围内保持气密密封。将第一力施加到柱塞以克服第一接触压力并将柱塞移出第一部分 并进入第二部分分配产品。 密封构件接合桶的第二部分以产生低于第一接触压力的第二接触压力。 低于第一力的第二力足以克服第二接触压力并将柱塞移动到第二部分中以继续分配产品。 注射器可以包括用于在冷冻期间容纳产品的膨胀的约束元件。

    A drug delivery device
    89.
    发明公开
    A drug delivery device 审中-公开
    Arzneimittelabgabevorrichtung

    公开(公告)号:EP2329857A1

    公开(公告)日:2011-06-08

    申请号:EP09177940.5

    申请日:2009-12-03

    IPC分类号: A61M5/315

    摘要: A drug delivery device comprises a housing (2) and a piston rod (13) arranged in the housing. The piston rod (13) is adapted to be moved along an axial direction to dispense a fluid. A drive member (5) arranged in the housing (2) is operatively coupled to the piston rod (13) and adapted to set up a dose of fluid for dispense in response to a first movement. The drive member (5) is also adapted to move the piston rod (13) to dispense the dose in response to a second movement. The drug delivery device also comprises a pre-dispensing drive member (18) operatively coupled to the drive member (5) and the housing (2) and adapted to move at least the drive member (5) by a pre-dispensing distance between its first and second movement.

    摘要翻译: 药物输送装置包括壳体(2)和布置在壳体中的活塞杆(13)。 活塞杆(13)适于沿着轴向移动以分配流体。 布置在壳体(2)中的驱动构件(5)可操作地联接到活塞杆(13)并且适于响应于第一移动而设置一定剂量的流体以进行分配。 驱动构件(5)还适于移动活塞杆(13)以响应于第二运动而分配剂量。 药物输送装置还包括可操作地联接到驱动构件(5)和壳体(2)的预分配驱动构件(18),并且适于使至少驱动构件(5)在其间的预分配距离 第一和第二动作。