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公开(公告)号：EP3777927A1
公开(公告)日：2021-02-17
申请号：EP20197287.4
申请日：2013-03-14
申请人： AbbVie Inc.
摘要： A syringe includes a barrel, a plunger, and a sealing member creating a seal between the plunger and the barrel. The barrel includes a first portion with a first inner diameter and a second portion with a second inner diameter that is larger than the first inner diameter. The sealing member engages the first portion of the barrel to give rise to a first contact pressure when the barrel is filled with product. The first contact pressure is sufficient to maintain a gas-tight seal over the expected temperature ranges -25°C to 40°C. A first force is applied to the plunger to overcome the first contact pressure and move the plunger out of the first portion and into the second portion to dispense product. The sealing member engages the second portion of the barrel to give rise to a second contact pressure that is lower than the first contact pressure. A second force lower than the first force is sufficient to overcome the second contact pressure and move the plunger in the second portion to continue dispensing product. The syringe may include a restraining element for accommodating expansion of the product during freezing.
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公开(公告)号：EP2956191A1
公开(公告)日：2015-12-23
申请号：EP13714114.9
申请日：2013-03-14
申请人： AbbVie Inc.
CPC分类号： A61M5/31513 , A61J7/0053 , A61J15/0015 , A61J15/0061 , A61J15/0069 , A61J15/0076 , A61M5/002 , A61M5/14546 , A61M5/3135 , A61M5/31501 , A61M5/31505 , A61M2005/3101 , A61M2005/3106 , A61M2005/3131 , A61M2005/31506 , A61M2205/8206
摘要： A syringe includes a barrel, a plunger, and a sealing member creating a seal between the plunger and the barrel. The barrel includes a first portion with a first inner diameter and a second portion with a second inner diameter that is larger than the first inner diameter. The sealing member engages the first portion of the barrel to give rise to a first contact pressure when the barrel is filled with product. The first contact pressure is sufficient to maintain a gas-tight seal over the expected temperature ranges -25 DEG C to 40 DEG C. A first force is applied to the plunger to overcome the first contact pressure and move the plunger out of the first portion and into the second portion to dispense product. The sealing member engages the second portion of the barrel to give rise to a second contact pressure that is lower than the first contact pressure. A second force lower than the first force is sufficient to overcome the second contact pressure and move the plunger in the second portion to continue dispensing product. The syringe may include a restraining element for accommodating expansion of the product during freezing.
摘要翻译： 注射器包括筒体，柱塞和在柱塞和筒体之间产生密封的密封构件。 枪管包括具有第一内径的第一部分和具有大于第一内径的第二内径的第二部分。 密封构件与筒体的第一部分接合以在桶体填充产品时产生第一接触压力。 第一接触压力足以在-25℃至40℃的预期温度范围内保持气密密封。将第一力施加到柱塞以克服第一接触压力并将柱塞移出第一部分 并进入第二部分分配产品。 密封构件接合桶的第二部分以产生低于第一接触压力的第二接触压力。 低于第一力的第二力足以克服第二接触压力并将柱塞移动到第二部分中以继续分配产品。 注射器可以包括用于在冷冻期间容纳产品的膨胀的约束元件。
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