公开(公告)号：EP1885650A1

公开(公告)日：2008-02-13

申请号：EP05812423.1

申请日：2005-09-16

申请人： ADA FOUNDATION

发明人： CHOW, Laurence, C. ,  SUN, Limin

IPC分类号： C01B25/16

CPC分类号： C01F11/22 ,  C01B25/322 ,  C01B25/455 ,  C01B33/24

摘要： Nano-particles of calcium and phosphorous compounds are made in a highly pure generally amorphous state by spray drying a weak acid solution of said compound and evaporating the liquid from the atomized spray in a heated column followed by collection of the precipitated particles. Hydroxyapatite (HA) particles formed by such apparatus and methods are examples of particle manufacture useful in bone and dental therapies. Dual nozzle spraying techniques are utilized for generally insoluble compounds.

公开(公告)号：EP1132431A4

公开(公告)日：2007-05-02

申请号：EP99972237

申请日：1999-11-12

申请人： MITSUI CHEMICALS INC

发明人： TAKAKI TOSHIHIKO ,  TANABE MASARU ,  ITOH HIROSHI ,  OYANAGI TOSHIKI

IPC分类号： A61K8/11 ,  A61K8/19 ,  A61K8/24 ,  A61K8/81 ,  A61Q19/00 ,  B01F17/00 ,  B01J13/00 ,  B41M5/00 ,  B41M5/52 ,  C01B25/32 ,  C01F11/18 ,  C08K3/00 ,  C09D11/00 ,  D21H19/36 ,  D21H19/38 ,  D21H19/42 ,  D21H19/58 ,  C08L101/14 ,  A61K7/00 ,  C08K3/32 ,  C08L29/04 ,  C08L33/26 ,  C08L39/06 ,  D21H19/00

CPC分类号： B41M5/52 ,  A61K8/11 ,  A61K8/19 ,  A61K8/24 ,  A61K8/8129 ,  A61K8/8135 ,  A61K8/8158 ,  A61K8/8176 ,  A61K8/8182 ,  A61K2800/413 ,  A61Q19/00 ,  B01F17/0028 ,  B01F17/005 ,  B01J13/0034 ,  B41M5/5218 ,  B41M5/5254 ,  B82Y30/00 ,  C01B25/322 ,  C01F11/183 ,  C01P2004/10 ,  C01P2004/62 ,  C01P2004/64 ,  C08K3/00 ,  C08K3/01 ,  C08K2201/003 ,  C09D11/30 ,  C09D11/38 ,  D21H19/36 ,  D21H19/38 ,  D21H19/42 ,  D21H19/58

摘要： An organic polymer/inorganic fine particle-dispersed aqueous solution having excellent dispersion stability comprising a water-slightly soluble inorganic fine particle (B) having a particle diameter of 500 nm or less obtained by reacting (a) a compound of a second group element in the periodic table with (b) at least one compound selected from organic acids, inorganic acids and salts thereof in the presence of a water-soluble or water-dispersible synthetic high molecular compound (A) having a carboxyl group in a proportion of (A) : (B) = 10 : 90 to 99.99 : 0.01 (weight ratio). The above dispersed aqueous solution can be used as a paper-making chemical, an ink jet recording chemical, medical materials and cosmetic raw materials.

公开(公告)号：EP1704115A1

公开(公告)日：2006-09-27

申请号：EP04805022.3

申请日：2004-12-23

申请人： Ecophos

发明人： TAKHIM, Mohamed

IPC分类号： C01B25/28 ,  C01B25/30 ,  C01B25/40 ,  C01B25/41

CPC分类号： C01B25/41 ,  C01B25/28 ,  C01B25/30 ,  C01B25/322 ,  C01B25/324 ,  C01B25/405

摘要： The inventive method for producing strong base phosphates consists in forming a pulp consisting of an aqueous phase which contains a water-soluble calcium phosphate and a solid impurity-containing phase, in separating said phases, transferring calcium ions to a liquid phase by a strong base ions associated with forming the aqueous solution of the pure phosphate(s) of said strong base and in precipitating a pure water-insoluble calcium phosphate. Said method also consists in mixing phosphoric ores and acid in such a way that a pasty triple superphosphate composition is obtained and in adding water thereto in order to produce said pulp.

摘要翻译： 用于生产强碱性磷酸盐的本发明方法在于形成由包含水溶性磷酸钙和含固体杂质的相的水相组成的纸浆，在分离所述相中，通过强碱将钙离子转移到液相 与形成所述强碱的纯磷酸盐的水溶液和沉淀纯水不溶性磷酸钙有关的离子。 所述方法还包括以下方式混合磷矿石和酸，使得获得糊状三过磷酸盐组合物并向其中加入水以生产所述纸浆。

公开(公告)号：EP1296888B1

公开(公告)日：2006-02-15

申请号：EP00954822.3

申请日：2000-07-03

申请人： Zakrytoe Aktsionernoe Obschestvo OSTIM

发明人： RUDIN, Vsevolod Nikolaevich ,  KOMAROV, Vladimir Fedorovich ,  MELIKHOV, Igor Vitallevich ,  MINAEV, Vladimir Vasillevich ,  ORLOV, Andrei Yurevich ,  BOZHEVOINOV, Viktor Evgenievich

IPC分类号： C01B25/32

CPC分类号： C01B25/322

摘要： The present invention especially relates to the mechanism and to the technological process for synthesizing nanosized crystalline hydroxyapatite. In particular, for producing nano-sized crystalline hydroxyapatite whose particles have nano dimensions in length "l", width, "d" and thickness "h", wherein "h" is practically corresponding to the size of one transmission of crystallographic cell a method is disclosed involving the steps of mixing and homogenizing a suspension comprising calcium hydroxide with an amount of phosphoric acid within a first reactor thereby adjusting a defined alkaline pH-value of the resulting mixture, feeding the mixture into a second reactor for causing phase transformations of the mixture and feeding the mixture into a third reactor for providing a suspension by adding a suspension of calcium hydroxide to the mixture to then feed the suspension into the first reactor, whereby each of these steps is cyclically carried out in continuos periodical conditions within at least three stages thereby producing nano-sized crystalline particles of pure hydroxyapatite as a solid phase.

公开(公告)号：EP1517856A2

公开(公告)日：2005-03-30

申请号：EP03735206.9

申请日：2003-06-26

申请人： Ecophos

发明人： TAKHIM, Mohamed

IPC分类号： C01B25/22

CPC分类号： C01B25/322 ,  C01B25/2212 ,  C01B25/461 ,  C05B11/12

摘要： A method for the production of phosphoric acid comprising a phosphate ore attack by a first aqueous chlorohydric acid solution, separation in the attack liquor between a solid insoluble phase containing impurities and a separate aqueous phase comprising phosphate ions in a solution, chloride ions and calcium ions, neutralization of said attack phase separated from the liquor by adding a calcium compound so that water-insoluble calcium phosphate can be formed with said phosphate ions, precipitating a separation in said neutralized aqueous phase comprising chloride ions and calcium ions in a solution and a solid precipitated phase based on said water-insoluble calcium phosphate, and solubilization of at least one part of the precipitated solid phase in a separated manner in a second aqueous chlorohydric acid solution, with formation of an aqueous solution containing phosphate ions, chloride ions and calcium ions to be extracted by an organic extractant in a liquid-liquid-type extraction.

公开(公告)号：EP0838430B1

公开(公告)日：2001-12-12

申请号：EP96922238.9

申请日：1996-07-05

申请人： MARUO CALCIUM COMPANY LIMITED

发明人： NISHIOKA, Hidehiko ,  TAKIYAMA, Shigeo ,  HANAZAKI, Minoru

IPC分类号： C01B25/32

CPC分类号： C08K7/24 ,  B01J20/048 ,  B01J20/28004 ,  B01J20/28011 ,  B01J20/28083 ,  B01J20/28085 ,  C01B25/32 ,  C01B25/322 ,  C01B25/324 ,  Y10T428/2982

公开(公告)号：EP0910546B1

公开(公告)日：2001-12-05

申请号：EP97941008.1

申请日：1997-06-20

申请人： Osteotech, Inc.,

发明人： SHIMP, Lawrence, A. ,  RENKEMA, Peter, J.

IPC分类号： C01B25/32

CPC分类号： A61L27/32 ,  A61F2310/00293 ,  A61F2310/00796 ,  A61K6/0008 ,  A61K6/0038 ,  A61K6/0085 ,  A61L27/12 ,  C01B25/322 ,  A61K6/097 ,  C08L5/12 ,  C08L1/286 ,  C08L1/28 ,  C08L1/284 ,  C08L1/04

摘要： A process for producing spherical, non-porous hydroxyapatite particles having a size which does not exceed 250 microns and having a density of at least 3.00 g/cc. The process comprises agglomerating in the presence of water as the only additive hydroxyapatite powder feedstock having a purity of at least 97 %, and having metallic impurities which do not exceed 500 ppm, to form hydroxyapatite particles having a size which does not exceed 350 microns. The particles are then dried and then sintered at a temperature from about 1,100 DEG C to about 1,200 DEG C to provide spherical, non-porous hydroxyapatite particles which do not exceed 250 microns and having a density of at least 3.00 g/cc. Such particles have a variety of medical uses, including bone replacement, implant coatings, and dental applications such as alveolar ridge augmentation, root extraction site fillings, restoration of periodontal osseous lesions, and soft tissue augmentations.

公开(公告)号：EP1110908A1

公开(公告)日：2001-06-27

申请号：EP99910716.2

申请日：1999-03-26

申请人： Nara Machinery Co., Ltd.

发明人： SENNA, Mamoru ,  ISOBE, Tetsuhiko ,  KANAYAMA, Manabu

IPC分类号： C01B25/32

CPC分类号： A61K6/033 ,  A61L27/12 ,  C01B25/322 ,  Y10S977/773 ,  Y10S977/775 ,  Y10S977/788 ,  Y10S977/904 ,  Y10S977/919 ,  Y10T428/2982 ,  Y10T428/2991 ,  Y10T428/2998

摘要： The present invention provides a method of synthesizing hydroxy apatite comprising the steps of preparing a mixed material slurry by dispersing calcium hydroxide (Ca(OH) 2 ) powder into a phosphoric acid (H 3 PO 4 ) solution; conducting a mechanochemical milling treatment in which shearing force and compressive force based on a centrifugal force of a mechanical rotating body are imparted to the mixed material slurry , and reacting the calcium hydrate component with the phosphoric acid component under normal temperature and pressure thereby to prepare hydroxy apatite (HAp) powder having fine crystals. According to the structure described above, there can be provided a method of synthesizing hydroxy apatite having fine and uniform particle size which can be directly synthesized under normal temperature and pressure in a short time through simple and single process.

摘要翻译： 本发明提供一种合成羟基磷灰石的方法，包括以下步骤：通过将氢氧化钙（Ca（OH）2）粉末分散在磷酸（H 3 PO 4）溶液中）来制备混合材料浆料; 进行机械化学研磨处理，其中基于机械旋转体的离心力的剪切力和压缩力被赋予混合材料浆料，并在常温常压下使钙水合物组分与磷酸组分反应，从而制备羟基 具有细晶体的磷灰石（HAP）粉末。 根据上述结构，可以提供一种合成具有微细且均匀粒径的羟基磷灰石的方法，其可以通过简单且单一的方法在短时间内在常温常压下直接合成。

公开(公告)号：EP0910546A4

公开(公告)日：1999-08-11

申请号：EP97941008

申请日：1997-06-20

申请人： OSTEOTECH INC

发明人： SHIMP LAWRENCE A ,  RENKEMA PETER J

IPC分类号： A61L27/00 ,  A61F2/00 ,  A61K6/033 ,  A61L27/12 ,  A61L27/32 ,  C01B25/32

CPC分类号： A61L27/32 ,  A61F2310/00293 ,  A61F2310/00796 ,  A61K6/0008 ,  A61K6/0038 ,  A61K6/0085 ,  A61L27/12 ,  C01B25/322 ,  A61K6/097 ,  C08L5/12 ,  C08L1/286 ,  C08L1/28 ,  C08L1/284 ,  C08L1/04

摘要： A process for producing spherical, non-porous hydroxyapatite particles having a size which does not exceed 250 microns and having a density of at least 3.00 g/cc. The process comprises agglomerating in the presence of water as the only additive hydroxyapatite powder feedstock having a purity of at least 97 %, and having metallic impurities which do not exceed 500 ppm, to form hydroxyapatite particles having a size which does not exceed 350 microns. The particles are then dried and then sintered at a temperature from about 1,100 DEG C to about 1,200 DEG C to provide spherical, non-porous hydroxyapatite particles which do not exceed 250 microns and having a density of at least 3.00 g/cc. Such particles have a variety of medical uses, including bone replacement, implant coatings, and dental applications such as alveolar ridge augmentation, root extraction site fillings, restoration of periodontal osseous lesions, and soft tissue augmentations.

摘要翻译： 生产尺寸不超过250微米并且密度至少为3.00g / cc的球形无孔羟基磷灰石颗粒的方法。 该方法包括在作为纯度至少97％的唯一添加剂羟基磷灰石粉末原料的水存在下凝聚并且具有不超过500ppm的金属杂质以形成尺寸不超过350微米的羟基磷灰石颗粒。 然后将颗粒干燥，然后在约1100℃至约1200℃的温度下烧结以提供不超过250微米并且密度至少为3.00g / cc的球形无孔羟基磷灰石颗粒。 这种颗粒具有多种医疗用途，包括骨替代，植入物涂层和牙齿应用，例如牙槽嵴增大，牙根提取部位填充，牙周骨质损伤的恢复和软组织增大。

公开(公告)号：EP0622990B1

公开(公告)日：1998-12-23

申请号：EP93923726.9

申请日：1993-09-24

申请人： NORIAN CORPORATION

发明人： CONSTANTZ, Brent, R.

IPC分类号： C01B25/32 ,  A61L27/00 ,  A61L25/00 ,  A61K6/033

CPC分类号： A61L24/02 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2210/0004 ,  A61F2310/00293 ,  A61K6/0067 ,  A61K6/0085 ,  A61L27/12 ,  A61L27/46 ,  A61L27/50 ,  A61L27/58 ,  C01B25/16 ,  C01B25/32 ,  C01B25/322 ,  C01B25/327 ,  C01B25/455 ,  C08L89/00 ,  A61K6/087 ,  A61K6/097 ,  C08L5/00

摘要： Carbonated hydroxyapatite compositions and their preparation are described. The compositions are biologically resorbable and are prepared as flowable masses which can be administered by syringe to set in situ to serve as a support structure, filler, prosthesis or the like. Optionally the compositions may include proteins or serve as a depot for compositions of pharmacological interest.