公开(公告)号：EP2753359B1

公开(公告)日：2018-02-28

申请号：EP12830126.4

申请日：2012-09-06

申请人： Translational Sciences Inc.

发明人： REED, Guy L.

IPC分类号： A61K39/395 ,  A61K48/00 ,  A61P25/00 ,  A61P35/00 ,  A61P9/00 ,  A61P11/00 ,  C07K16/18 ,  A61K39/00 ,  C07K16/38

CPC分类号： C07K16/38 ,  A61K2039/505 ,  C07K16/18

摘要： Compositions and methods of using SerpinF2-binding molecules for preventing and/or reducing organ damage, functional disability or mortality in a patient at risk due to the activity of SerpinF2 and/or plasminogen activators on tissue injury. Also provided are compositions and methods of using SerpinF2-binding molecules for inhibiting hemorrhage, edema, and apoptosis. Methods for the preparation of medicaments for such methods of treatment and prevention are provided.

公开(公告)号：EP3237007A1

公开(公告)日：2017-11-01

申请号：EP15874231.2

申请日：2015-12-21

申请人： Translational Sciences Inc.

发明人： REED, Guy L.

IPC分类号： A61K39/395 ,  C07K16/38 ,  A61P9/10

CPC分类号： C07K16/38 ,  A61K2039/505

摘要： The invention provides a method and composition for preventing thrombosis and complications associated therewith by targeting Sf2 directly. The invention provides Sf2-deficiency or prophylactic administration of a therapeutic agent, such as a Sf2 antagonist or a Sf2 antibody, markedly reduces thrombus formation that would otherwise be caused due to surgery, immobility, genetic abnormality, cancer, trauma, or other risk factors.

摘要翻译： 本发明提供了通过直接靶向Sf2来预防血栓形成和与之相关的并发症的方法和组合物。 本发明提供了治疗剂例如Sf2拮抗剂或Sf2抗体的Sf2缺陷或预防性给药，显着减少否则会由于手术，不动，遗传异常，癌症，创伤或其他风险因素而引起的血栓形成 。

公开(公告)号：EP2542257B1

公开(公告)日：2017-07-05

申请号：EP11751244.2

申请日：2011-03-01

申请人： Bayer Healthcare LLC

发明人： SCHOLZ, Peter ,  WANG, Zhuozhi ,  PAN, Junliang ,  GRUDZINSKA, Joanna ,  VOTSMEIER, Christian ,  TEBBE, Jan ,  BIRKENFELD, Jörg ,  WOBST, Nina ,  BRÜCKNER, Simone ,  STEINIG, Susanne

IPC分类号： C07K16/38 ,  A61K39/00 ,  A61K39/395

CPC分类号： C07K16/38 ,  A61K2039/505 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/21

摘要： Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) are provided. Isolated nucleic acid molecules encoding monoclonal antibodies that bind TFPI are also contemplated. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.

摘要翻译： 提供了结合人组织因子途径抑制剂（TFPI）的分离的单克隆抗体。 还考虑了编码结合TFPI的单克隆抗体的分离的核酸分子。 还提供了包含抗TFPI单克隆抗体的药物组合物和通过施用抗体治疗凝血缺陷或缺陷的方法。 还提供了产生抗体的方法。

公开(公告)号：EP3177312A1

公开(公告)日：2017-06-14

申请号：EP15747488.3

申请日：2015-08-06

申请人： Randox Laboratories Ltd.

发明人： TAGGART, Clifford ,  WELDON, Sinead ,  SCOTT, Chris

IPC分类号： A61K38/08 ,  C07K16/38 ,  A61K39/385

CPC分类号： G01N33/573 ,  C07K5/1021 ,  C07K16/38 ,  C07K16/40 ,  C07K2317/34 ,  G01N2333/96425 ,  G01N2800/26

摘要： The invention relates to a novel antibody which binds to C-SLPI selected from the group consisting of SEQ ID NOs: 3 and 4.

摘要翻译： 本发明涉及结合选自SEQ ID NO：3和4的C-SLPI的新型抗体。

公开(公告)号：EP2970498A4

公开(公告)日：2016-11-23

申请号：EP14765680

申请日：2014-03-14

申请人： BAYER HEALTHCARE LLC

发明人： WANG ZHUOZHI ,  MURPHY JOHN ,  HERMISTON TERRY ,  ZHU YING ,  WINTER RUTH

IPC分类号： C07K16/36 ,  C07K16/18 ,  C07K16/38

CPC分类号： C07K16/36 ,  C07K16/18 ,  C07K16/38 ,  C07K2317/35 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/50

摘要： This disclosure provides pro-drug antibodies which specifically bind to tissue factor pathway inhibitor (TFPI) only after exposure to proteases from the coagulation cascade. The pro-drug antibodies described are useful for treating bleeding disorders such as hemophilia. When used in such treatments, these pro-drug antibodies show increased half-life relative to other anti-TFPI antibodies, while mitigating the potential for side effects such as thrombosis.

公开(公告)号：EP3033359A1

公开(公告)日：2016-06-22

申请号：EP14761451.5

申请日：2014-08-13

申请人： SANOFI

发明人： PRITSKER, Alla ,  GRAILHE, Patrick ,  RAK, Alexey ,  MATHIEU, Magali ,  MORGAN, Christopher Ryan ,  BAURIN, Nicolas ,  POIRIER, Bruno ,  DAVEU, Cyril ,  DUFFIEUX, Francis ,  LI, Han ,  KOMINOS, Dorothea ,  JANIAK, Philip

IPC分类号： C07K16/38

摘要： The invention provides antibodies that specifically bind to Plasminogen Activator inhibitor type-1 (PAI-1), The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-PAI-1 antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies to modulate PAI-1 activity or detect PAI-1, either in vitro or in vivo, are also provided. The disclosure further provides methods of making antibodies that specifically bind to PAI-1 in the active conformational state.

摘要翻译： 本发明提供了特异性结合纤溶酶原激活物抑制剂1型（PAI-1）的抗体。本发明还提供了药物组合物，以及编码抗PAI-1抗体的核酸，用于制备这种抗体的重组表达载体和宿主细胞 ，或其片段。 还提供了在体外或体内使用抗体调节PAI-1活性或检测PAI-1的方法。 本公开进一步提供了制备特异性结合活性构象状态的PAI-1的抗体的方法。

公开(公告)号：EP2970500A1

公开(公告)日：2016-01-20

申请号：EP14722465.3

申请日：2014-03-14

申请人： Bayer HealthCare LLC

发明人： JIN, Ye ,  MURPHY, John, E. ,  HERMISTON, Terry ,  MYLES, Timothy ,  DITTMER, Frank ,  STRERATH, Michael ,  GRITZAN, Uwe

IPC分类号： C07K16/38 ,  C12N15/13 ,  A61K39/395 ,  A61P7/04

CPC分类号： C07K16/36 ,  A61K38/4846 ,  A61K45/06 ,  C07K16/18 ,  C07K16/38 ,  C07K2317/21 ,  C07K2317/32 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565

摘要： This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin &bgr; complexed with heparin and/or heparin-like structure (AT&bgr;H). These AT&bgr;H binding proteins can block the anti-coagulant activity of AT&bgr; to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.

摘要翻译： 该专利文献涉及针对人类抗凝血酶的抗体，抗原结合抗体片段（Fabs）和其它蛋白质支架; 与肝素和/或肝素样结构复合（AT＆amp; H）。 这些AT＆Bgr H结合蛋白可以阻断AT＆Bgr的抗凝血活性; 诱导凝血。 这些抗体和结合物的治疗用途在本文中描述为淘选和筛选特异性抗体的方法。

公开(公告)号：EP2619581B1

公开(公告)日：2015-09-30

申请号：EP11826474.6

申请日：2011-09-23

申请人： Grifols Therapeutics Inc.

发明人： GREBE, Marco

IPC分类号： C07K16/38 ,  G01N33/558 ,  G01N33/543 ,  G01N33/68

CPC分类号： G01N33/6893 ,  C07K16/38 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/558 ,  G01N2333/8125

摘要： A membrane-based assay device, methods and kits for determining the presence or quantity of an analyte in a test sample are provided. The immunochromatographic device comprises a membrane having a capture antibody bound thereto at a test zone, wherein the capture antibody is capable of binding with an analyte, in particular a Z-AAT protein present in a sample from a PiZ gene carrier.

公开(公告)号：EP2391654A4

公开(公告)日：2012-08-01

申请号：EP10735454

申请日：2010-01-27

申请人： IND TECH RES INST

发明人： LIN WEI-YA ,  YEH MARY YA-PING ,  TSENG TZU-LING ,  CHENG PING-FU ,  HSU TSAI-WEI ,  LI HUNG-YI ,  CHEN YI-TING ,  LIN YUH-FENG ,  CHEN GIIEN-SHUEN ,  LI YEN-PENG

IPC分类号： C07K16/38 ,  C07K14/47 ,  C07K14/81 ,  C07K16/18 ,  C40B30/00 ,  G01N33/53 ,  G01N33/573 ,  G01N33/68

CPC分类号： G01N33/6893 ,  G01N2333/4728 ,  G01N2333/52 ,  G01N2333/71 ,  G01N2333/8125 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56

公开(公告)号：EP1078003B1

公开(公告)日：2009-08-19

申请号：EP99918966.5

申请日：1999-05-07

申请人： THE UNIVERSITY OF QUEENSLAND ,  National Institute of Biological Standards and Control, United Kingdom

发明人： MASCI, Pantaleone, Paul ,  LAVIN, Martin, Francis ,  GAFFNEY, Patrick, Joseph ,  SOROKINA, Natalya, Igorevna ,  FILIPPOVICH, Igor, Vladimirovich

IPC分类号： C07K14/81 ,  C07K16/38 ,  C07H21/04 ,  A61K38/17 ,  A61K38/36 ,  A61K39/44 ,  C07K14/46 ,  A61K47/48

CPC分类号： C07K14/46 ,  A61K47/6811 ,  A61K47/6843

摘要： The invention provides novel single stage competitive inhibitors of plasmin from the Australian brown snake Pseudonaja textilis textilis. The invention also features polynucleotides and polynucleotide homologues encoding these inhibitors. Pharmaceutical compositions containing the plasmin inhibitors of the invention are also disclosed as well as methods useful for treatment of blood loss.