-
1.发明授权RETROVIRAL VECTORS CARRYING SENESCENT CELL DERIVED INHIBITORS 1 (SDI-1) OR ANTISENSE SDI-1 NUCLEOTIDE SEQUENCES 失效逆转录病毒载体是DNA合成（SDI-1），或反义SDI-1的核苷酸序列的抑制剂CARRY
公开(公告)号：EP0859854B1
公开(公告)日：2002-05-02
申请号：EP96934660.0
申请日：1996-10-11
IPC分类号： C12N15/867 , C07K14/47 , A61K38/17 , C12N15/11
CPC分类号： C12N15/86 , A61K38/00 , C07K14/4703 , C12N2740/13043
-
公开(公告)号：EP0817859B1
公开(公告)日：2002-01-16
申请号：EP96907399.8
申请日：1996-03-08
IPC分类号： C12N15/867 , A61K38/16 , A61K48/00
CPC分类号： C12N15/86 , A61K38/162 , A61K48/00 , C07K14/005 , C12N2740/13022 , C12N2740/13043
摘要： The invention refers to novel recombinant vectors useful for gene therapy of viral infections and of diseases associated with B and T cells. The present invention relates, furthermore, to novel usages of the two products of the open reading frame of mouse mammary tumour virus.
-
公开(公告)号：EP1162273A1
公开(公告)日：2001-12-12
申请号：EP01118945.3
申请日：1996-03-08
发明人： Günzburg, Walter , Salmons, Brian
IPC分类号： C12N15/867 , A61K38/16 , A61K48/00
CPC分类号： C12N15/86 , A61K38/162 , A61K48/00 , C07K14/005 , C12N2740/13022 , C12N2740/13043
摘要： The invention refers to novel recombinant vectors useful for gene therapy of viral infections and of diseases associated with B and T cells. The present invention relates, furthermore, to novel usages of one product of the open reading frame of mouse mammary tumour virus.
摘要翻译： 本发明涉及可用于病毒感染的基因治疗和与B和T细胞相关疾病的新型重组载体。 本发明还涉及小鼠乳腺肿瘤病毒的开放阅读框架的一种产品的新颖用途。
-
公开(公告)号：EP1092035A2
公开(公告)日：2001-04-18
申请号：EP99932760.4
申请日：1999-06-30
CPC分类号： C12N15/86 , C12N2740/13043
摘要： To achieve the foregoing and other objects, the present invention provides a retroviral vector comprising in its LTRs sequences, preferably sequences of an adeno-associated virus, for a targeted integration.
-
5.发明授权
公开(公告)号：EP0817858B1
公开(公告)日：2003-04-23
申请号：EP96907398.0
申请日：1996-03-08
CPC分类号： C12N15/86 , A61K48/00 , C07K14/43563 , C07K14/43572 , C12N2740/13043
摘要： The present invention relates to retroviral vectors carrying sequences encoding naturally occuring, antimicrobial peptides or derivatives thereof for the treatment of mammalian tumours, viral infections such as HIV infection and bacterial and fungal infections. In particular the present invention relates to retroviral vectors which undergo promoter conversion (Procon vectors) carrying such sequences. Since these vectors also carry tumour or virus specific regulatory elements, the therapeutic antimicrobial peptide will be delivered and expressed only in relevant, affected cells and not in innocent bystander cells.
-
6.发明授权THE USE OF THE WAP OF MMTV REGULATORY SEQUENCES FOR TARGETED EXPRESSION OF LINKED HETEROLOGOUS GENES IN HUMAN MAMMARY CELLS, INCLUDING HUMAN MAMMARY CARCINOMA CELLS 失效在人乳腺癌细胞，包括人BRUSTKARZIONOMZELLEN异源基因的表达或WAP MMTV的调控序列的控制之下
公开(公告)号：EP0848757B1
公开(公告)日：2002-03-06
申请号：EP96931040.8
申请日：1996-09-06
IPC分类号： C12N15/867 , A61K48/00 , C12N15/85 , C12N5/10
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C12N9/0042 , C12N15/85 , C12N2740/13043 , C12N2800/108 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of the WAP or MMTV regulatory sequences for the targeted expression of linked heterologous DNA sequences in human mammary cells, including human mammary carcinoma cells.
-
7.发明公开
公开(公告)号：EP1144667A2
公开(公告)日：2001-10-17
申请号：EP00918779.0
申请日：2000-03-09
IPC分类号： C12N15/867 , C12N5/10 , C12N7/01 , A61K48/00
CPC分类号： C12N15/86 , C12N2740/13043
摘要： The invention relates to retroviral expression vectors with cell-specifically modulatable promotors. The vectors can be used, for example, for the cell-specific expression of therapeutically valuable genes in gene therapy. The invention specifically relates to retroviral expression vectors containing at least the following elements, in a functional configuration: a) DNA sequences for the packaging of the vector RNA and for the cell-specific expression of proteins or peptides which are coded by heterologous DNA nucleotide sequences; b) one or more DNA nucleotide sequences coding for a protein or a peptide and characterized in that for cell-specific expression said DNA sequences contain a cell-specifically modulatable promotor region of a human endogenous retroviral DNA nucleotide sequence (HERV).
-
公开(公告)号：EP1115879A1
公开(公告)日：2001-07-18
申请号：EP99950543.1
申请日：1999-09-23
发明人： GÜNZBURG, Walter , SALMONS, Brian , BAUMANN, Jörg
CPC分类号： C12N7/00 , A61K35/12 , A61K48/00 , C12N15/86 , C12N2740/13052
摘要： The present invention relates to retroviral particles which are specifically applicable as safe gene transfer vehicles for targeted gene therapy and which are protected against complement mediated destruction in host organisms. For producing such retroviral particles a packaging cell is provided according to the present invention comprising a DNA construct coding for one or more complement inhibitors. Said inhibitors are derived from the complement system of the organism to be infected by the retroviral particle generated by the packaging cell.
-
公开(公告)号：EP0817860B1
公开(公告)日：2001-05-02
申请号：EP96909135.4
申请日：1996-03-27
发明人： SALMONS, Brian , BAUMANN, Jörg
IPC分类号： C12N15/867 , C12N5/10 , A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , C12N2740/13052
摘要： The present invention relates to a retroviral vector system comprising a packaging cell line that synthesize the core and enzymatic proteins of MLV virus from one or more gag and pol containing constructs and the envelope of MMTV virus from the same or an independent env containing construct, and to pseudotyped retroviral particles produced by culturing said retroviral vector system transfected with a MLV based retroviral vector, and isolation of said pseudotyped retroviral particles.
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.012 秒)
