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1.发明授权RETROVIRAL VECTORS CARRYING SENESCENT CELL DERIVED INHIBITORS 1 (SDI-1) OR ANTISENSE SDI-1 NUCLEOTIDE SEQUENCES 失效逆转录病毒载体是DNA合成（SDI-1），或反义SDI-1的核苷酸序列的抑制剂CARRY
公开(公告)号：EP0859854B1
公开(公告)日：2002-05-02
申请号：EP96934660.0
申请日：1996-10-11
IPC分类号： C12N15/867 , C07K14/47 , A61K38/17 , C12N15/11
CPC分类号： C12N15/86 , A61K38/00 , C07K14/4703 , C12N2740/13043
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公开(公告)号：EP0817859B1
公开(公告)日：2002-01-16
申请号：EP96907399.8
申请日：1996-03-08
IPC分类号： C12N15/867 , A61K38/16 , A61K48/00
CPC分类号： C12N15/86 , A61K38/162 , A61K48/00 , C07K14/005 , C12N2740/13022 , C12N2740/13043
摘要： The invention refers to novel recombinant vectors useful for gene therapy of viral infections and of diseases associated with B and T cells. The present invention relates, furthermore, to novel usages of the two products of the open reading frame of mouse mammary tumour virus.
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公开(公告)号：EP0817860B1
公开(公告)日：2001-05-02
申请号：EP96909135.4
申请日：1996-03-27
发明人： SALMONS, Brian , BAUMANN, Jörg
IPC分类号： C12N15/867 , C12N5/10 , A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , C12N2740/13052
摘要： The present invention relates to a retroviral vector system comprising a packaging cell line that synthesize the core and enzymatic proteins of MLV virus from one or more gag and pol containing constructs and the envelope of MMTV virus from the same or an independent env containing construct, and to pseudotyped retroviral particles produced by culturing said retroviral vector system transfected with a MLV based retroviral vector, and isolation of said pseudotyped retroviral particles.
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4.发明授权THE USE OF THE WAP OF MMTV REGULATORY SEQUENCES FOR TARGETED EXPRESSION OF LINKED HETEROLOGOUS GENES IN HUMAN MAMMARY CELLS, INCLUDING HUMAN MAMMARY CARCINOMA CELLS 失效在人乳腺癌细胞，包括人BRUSTKARZIONOMZELLEN异源基因的表达或WAP MMTV的调控序列的控制之下
公开(公告)号：EP0848757B1
公开(公告)日：2002-03-06
申请号：EP96931040.8
申请日：1996-09-06
IPC分类号： C12N15/867 , A61K48/00 , C12N15/85 , C12N5/10
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C12N9/0042 , C12N15/85 , C12N2740/13043 , C12N2800/108 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of the WAP or MMTV regulatory sequences for the targeted expression of linked heterologous DNA sequences in human mammary cells, including human mammary carcinoma cells.
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公开(公告)号：EP0835137B1
公开(公告)日：2005-11-09
申请号：EP96923905.2
申请日：1996-06-24
CPC分类号： C12N15/86 , A61K9/5026 , A61K9/5042 , A61K48/00 , C12N7/00 , C12N11/04 , C12N2740/13021 , C12N2740/13043
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6.发明公开THE USE OF THE WAP OF MMTV REGULATORY SEQUENCES FOR TARGETED EXPRESSION OF LINKED HETEROLOGOUS GENES IN HUMAN MAMMARY CELLS, INCLUDING HUMAN MAMMARY CARCINOMA CELLS 失效在人乳腺癌细胞，包括人BRUSTKARZIONOMZELLEN异源基因的表达或WAP MMTV的调控序列的控制之下
公开(公告)号：EP0848757A1
公开(公告)日：1998-06-24
申请号：EP96931040.0
申请日：1996-09-06
申请人： Bavarian Nordic Research Institute A/S , GSF - Forschungszentrum für Umwelt und Gesundheit, GmbH
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C12N9/0042 , C12N15/85 , C12N2740/13043 , C12N2800/108 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of the WAP or MMTV regulatory sequences for the targeted expression of linked heterologous DNA sequences in human mammary cells, including human mammary carcinoma cells.
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公开(公告)号：EP0817859A1
公开(公告)日：1998-01-14
申请号：EP96907399.0
申请日：1996-03-08
CPC分类号： C12N15/86 , A61K38/162 , A61K48/00 , C07K14/005 , C12N2740/13022 , C12N2740/13043
摘要： The invention refers to novel recombinant vectors useful for gene therapy of viral infections and of diseases associated with B and T cells. The present invention relates, furthermore, to novel usages of the two products of the open reading frame of mouse mammary tumour virus.
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8.发明公开RETROVIRAL VECTORS CARRYING SENESCENT CELL DERIVED INHIBITORS 1 (SDI-1) OR ANTISENSE SDI-1 NUCLEOTIDE SEQUENCES 失效逆转录病毒载体WEAR DNA合成（SDI-1），或反义SDI-1的核苷酸序列的抑制剂
公开(公告)号：EP0859854A1
公开(公告)日：1998-08-26
申请号：EP96934660.0
申请日：1996-10-11
CPC分类号： C12N15/86 , A61K38/00 , C07K14/4703 , C12N2740/13043
摘要： The present invention relates to retroviral vectors carrying DNA sequences encoding SDI-1, functional analogues or fragments thereof, or antisense SDI-1 DNA sequences, and especially retroviral vectors carrying SDI-1 or antisense SDI-1 sequences under transcriptional control of target cell specific regulatory elements or promoters or X-ray inducible promoters.
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公开(公告)号：EP0835137A1
公开(公告)日：1998-04-15
申请号：EP96923905.0
申请日：1996-06-24
CPC分类号： C12N15/86 , A61K9/5026 , A61K9/5042 , A61K48/00 , C12N7/00 , C12N11/04 , C12N2740/13021 , C12N2740/13043
摘要： The present invention relates to encapsulated cells producing viral particles, especially retroviral particles containing the genome of a viral vector carrying therapeutic genes, methods for the preparation of such encapsulated cells, as well as the use of such encapsulated cells for the treatment of diseases.
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公开(公告)号：EP0817860A1
公开(公告)日：1998-01-14
申请号：EP96909135.0
申请日：1996-03-27
发明人： SALMONS, Brian , BAUMANN, Jörg
CPC分类号： C12N15/86 , A61K48/00 , C12N2740/13052
摘要： The present invention relates to a retroviral vector system comprising a packaging cell line that synthesize the core and enzymatic proteins of MLV virus from one or more gag and pol containing constructs and the envelope of MMTV virus from the same or an independent env containing construct, and to pseudotyped retroviral particles produced by culturing said retroviral vector system transfected with a MLV based retroviral vector, and isolation of said pseudotyped retroviral particles.
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