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公开(公告)号：EP2276837A1
公开(公告)日：2011-01-26
申请号：EP09747244.3
申请日：2009-05-08
发明人： LAROSSA, Robert, A.
摘要： Yeast cells with a reduced general control response to amino acid starvation were found to have increased tolerance to butanol in the growth medium. The reduced response was engineered by genetic modification of a gene involved in the response, a
GCN gene, to eliminate activity of the encoded protein. Yeast strains with an engineered butanol biosynthetic pathway and a genetic modification in a gene involved in the general control response to amino acid starvation, which have increased butanol tolerance, are useful for production of butanol.-
2.发明公开METHOD FOR CONTROLLING THE BUTANOL CONCENTRATION IN A FERMENTATION BROTH DURING BUTANOL PRODUCTION 审中-公开甲醇的发酵液中CHECKING丁醇浓缩期间BUTANOLHERSTELLUNG
公开(公告)号：EP2217712A2
公开(公告)日：2010-08-18
申请号：EP08861309.6
申请日：2008-12-12
发明人： PARTEN, William, D.
IPC分类号： C12P7/16
摘要： The present invention relates to a two stage process to control the butanol concentration from fermentation broth.
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3.发明公开METHOD FOR PRODUCING BUTANOL USING EXTRACTIVE FERMENTATION WITH OSMOLYTE ADDITION 审中-公开PROCESS FOR与萃取发酵生产丁醇时加入渗透剂
公开(公告)号：EP2504447A2
公开(公告)日：2012-10-03
申请号：EP10784647.9
申请日：2010-11-23
摘要： A method is provided for producing butanol through microbial fermentation, in which the butanol product is removed during the fermentation by extraction into a water-immiscible organic extractant in the presence of at least one osmolyte at a concentration at least sufficient to increase the butanol partition coefficient relative to that in the presence of the osmolyte concentration of the basal fermentation medium and of an optional fermentable carbon source. The osmolyte may comprise a monosaccharide, a disaccharide, glycerol, sugarcane juice, molasses, polyethylene glycol, dextran, high fructose corn syrup, corn mash, starch, cellulose, and combinations thereof. Also provided is a method and composition for recovering butanol from a fermentation medium.
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公开(公告)号：EP2536821A2
公开(公告)日：2012-12-26
申请号：EP11745229.2
申请日：2011-02-17
发明人： FLINT, Dennis , PAUL, Brian James , YE, Rick, W.
CPC分类号： C12P7/16 , C07K14/395 , C12N9/88 , C12N15/81 , C12P7/40 , C12P13/02 , C12P13/04 , C12Q1/527 , C12Y402/01009 , G01N33/573 , Y02E50/10 , Y02P20/52
摘要： The present invention is related to a recombinant host cell, in particular a yeast cell, comprising a dihydroxy-acid dehydratase polypeptide. The invention is also related to a recombinant host cell having increased specific activity of the dihydroxy-acid dehydratase polypeptide as a result of increased expression of the polypeptide, modulation of the Fe-S cluster biosynthesis of the cell, or a combination thereof. The present invention also includes methods of using the host cells, as well as, methods for identifying polypeptides that increase the flux in an Fe-S cluster biosynthesis pathway in a host cell.
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5.发明公开METHOD FOR PRODUCING BUTANOL USING EXTRACTIVE FERMENTATION WITH ELECTROLYTE ADDITION 审中-公开用于利用添加电解质萃取发酵生产丁醇
公开(公告)号：EP2504446A1
公开(公告)日：2012-10-03
申请号：EP10782795.8
申请日：2010-11-23
摘要： A method for producing butanol through microbial fermentation, in which the butanol product is removed during the fermentation by extraction into a water-immiscible organic extractant in the presence of at least one electrolyte at a concentration at least sufficient to increase the butanol partition coefficient relative to that in the presence of the salt concentration of the basal fermentation medium, is provided. The electrolyte may comprise a salt which dissociates in the fermentation medium, or in the aqueous phase of a biphasic fermentation medium, to form free ions. Also provided is a method and composition for recovering butanol from a fermentation medium.
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6.发明公开CARBON PATHWAY OPTIMIZED PRODUCTION HOSTS FOR THE PRODUCTION OF ISOBUTANOL 审中-公开KOHLENSTOFFWEG优化生产宿主用于生产异丁醇
公开(公告)号：EP2350298A1
公开(公告)日：2011-08-03
申请号：EP09741177.1
申请日：2009-10-27
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/1205 , C12N9/18 , C12N9/88 , C12N9/92 , Y02E50/10
摘要： A microbial host cell is provided for the production of isobutanol. Carbon flux in the cell is optimized through the Entner-Doudorof pathway.
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7.发明公开IMPROVING ACTIVITY OF FE-S CLUSTER REQUIRING PROTEINS 有权VERBESSERUNG DER WIRKUNG VON FE-S-BÜNDELERFORDERNDEN PROTEINEN
公开(公告)号：EP2536821A4
公开(公告)日：2014-01-29
申请号：EP11745229
申请日：2011-02-17
发明人： FLINT DENNIS , PAUL BRIAN JAMES , YE RICK W
CPC分类号： C12P7/16 , C07K14/395 , C12N9/88 , C12N15/81 , C12P7/40 , C12P13/02 , C12P13/04 , C12Q1/527 , C12Y402/01009 , G01N33/573 , Y02E50/10 , Y02P20/52
摘要： The present invention is related to a recombinant host cell, in particular a yeast cell, comprising a dihydroxy-acid dehydratase polypeptide. The invention is also related to a recombinant host cell having increased specific activity of the dihydroxy-acid dehydratase polypeptide as a result of increased expression of the polypeptide, modulation of the Fe—S cluster biosynthesis of the cell, or a combination thereof. The present invention also includes methods of using the host cells, as well as, methods for identifying polypeptides that increase the flux in an Fe—S cluster biosynthesis pathway in a host cell.
摘要翻译： 本发明涉及包含二羟基酸脱水酶多肽的重组宿主细胞，特别是酵母细胞。 本发明还涉及由于多肽表达增加，细胞的Fe-S簇生物合成调节或其组合而导致的二羟基酸脱水酶多肽的比活性增加的重组宿主细胞。 本发明还包括使用宿主细胞的方法，以及用于鉴定增加宿主细胞中Fe-S簇生物合成途径中的通量的多肽的方法。
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8.发明公开PROCESS TO REMOVE PRODUCT ALCOHOL FROM A FERMENTATION BY VAPORIZATION UNDER VACUUM 审中-公开程序脱除产物醇从发酵通过蒸发真空条件
公开(公告)号：EP2533873A2
公开(公告)日：2012-12-19
申请号：EP11742723.7
申请日：2011-02-09
CPC分类号： C07C29/80 , B01D3/002 , B01D53/1475 , B01D53/1487 , B01D2251/306 , B01D2251/606 , B01D2252/2025 , B01D2252/20484 , B01D2252/20489 , B01D2257/504 , B01D2257/704 , B01D2257/708 , B01D2257/80 , C07C29/76 , Y02C10/06 , Y02P20/152 , Y02P70/34 , C07C31/12
摘要： A fermentation liquid feed including water and a product alcohol and optionally CO
2 is at least partially vaporized such that a vapor stream is produced. The vapor stream is contacted with an absorption liquid under suitable conditions wherein an amount of the product alcohol is absorbed. The portion of the vapor stream that is absorbed can include an amount of each of the water, the product alcohol and optionally the CO
2 . The temperature at the onset of the absorption of the vapor stream into the absorption liquid can be greater than the temperature at the onset of condensation of the vapor stream in the absence of the absorption liquid. The product alcohol can be separated from the absorption liquid whereby the absorption liquid is regenerated. The absorption liquid can include a water soluble organic molecule such as an amine.-
公开(公告)号：EP2283135A1
公开(公告)日：2011-02-16
申请号：EP09759399.0
申请日：2009-06-04
CPC分类号： C12N9/0006 , C12P7/16 , Y02E50/10
摘要： An
E. coli host strain was engineered wherein genes adhE, ldhA, frdB, and pflB were disrupted and novel butanol dehydrogenase gene, sadB, from
Achromobacter xylosoxidans , was added to produce the isobutanol production host.-
公开(公告)号：EP2222841A2
公开(公告)日：2010-09-01
申请号：EP08868361.0
申请日：2008-12-18
CPC分类号： C12P7/16 , C12N9/0006 , Y02E50/10
摘要： Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from
Pseudomonas that have undergone co-factor switching to bind NADH are described.
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