公开(公告)号：EP2380606A1

公开(公告)日：2011-10-26

申请号：EP11167978.3

申请日：2007-06-28

申请人： Cook Incorporated ,  Med Institute, Inc.

发明人： Reyes, Priscilla T. ,  Moore, William F. ,  Ruane, Patrick ,  Myers, Randy J.

IPC分类号： A61L31/16

CPC分类号： A61L31/16 ,  A61L2300/416 ,  A61L2300/606

摘要： This disclosure relates to endolumenal medical devices coated with a taxane therapeutic agent in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous paclitaxel, dihydrate paclitaxel, or combinations thereof that provide durable coatings that release paclitaxel over a desired period of time, which can be on the order of hours, days or weeks. Preferred embodiments relate to medical device coatings of paclitaxel, or paclitaxel analogs or derivatives, having one or more polymorph solid forms that provide a prolonged release of paclitaxel within a body vessel without requiring a polymer carrier or barrier layer to achieve the desired rate of paclitaxel elution.

摘要翻译： 本发明涉及具有不同的溶解速率涂覆有一种或多种固体形式的（S）紫杉烷治疗剂腔内的医疗装置。 尤其优选的涂层包含无定形的紫杉醇，紫杉醇水合物，或它们的组合确实提供耐久性涂料确实释放紫杉醇在一段所希望的期间，它可以是数小时，数天或数周的数量级。 优选实施方案涉及紫杉醇的医疗装置的涂层，或紫杉醇类似物或衍生物，其具有一个或多个多态性的固体形式确实提供身体血管内紫杉醇的延长释放，而不需要的聚合物载体或阻挡层，以实现紫杉醇洗脱的所需的速率 ，

公开(公告)号：EP2324866A3

公开(公告)日：2011-10-26

申请号：EP10182721.0

申请日：2003-07-14

申请人： Cook Incorporated ,  Med Institute, Inc. ,  William Cook Europe ApS

发明人： Bates, Brian, L. ,  Boatman, Scott, E. ,  Burton, David, G. ,  Hoffa, Michael, C. ,  Ragheb, Anthony, O. ,  Schaeffer, Darin, G. ,  Sturgeon, Jason S.

IPC分类号： A61L31/16 ,  A61L29/16 ,  A61L27/54

CPC分类号： A61M25/10 ,  A61F2/82 ,  A61F2/844 ,  A61F2/86 ,  A61F2/958 ,  A61F2210/0014 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0025 ,  A61F2250/0026 ,  A61F2250/0067 ,  A61F2250/0081 ,  A61F2250/0098 ,  A61F2310/00011 ,  A61L27/54 ,  A61L29/08 ,  A61L29/085 ,  A61L29/16 ,  A61L29/18 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/06 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2250/00

摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.

摘要翻译： 一种涂覆的医疗装置（10），包括适于引入患者的通道或血管中的结构（12）。 该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。 医疗装置优选为植入式支架或球囊（26），其中生物活性材料层沉积在其上。 支架可以定位在球囊周围并且另一层生物活性材料位于整个结构上并且延伸超过定位的支架的端部。 气囊的端部延伸超过支架的端部并在其上包括生物活性材料以将生物活性材料递送到与其接触的血管壁的细胞。 气囊还包括位于气囊的基部和生物活性材料层之间的亲水材料层（58）。

公开(公告)号：EP2376174A1

公开(公告)日：2011-10-19

申请号：EP08876483.2

申请日：2008-12-01

申请人： Cook Incorporated ,  William Cook Europe APS ,  Global Therapeutics, Llc

发明人： CHAMBERS, Sean, D. ,  AGGERHOLM, Steen ,  HORN, Joe

IPC分类号： A61M29/00 ,  A61B17/22

CPC分类号： A61M25/104 ,  A61B17/320725 ,  A61B2017/00539 ,  A61B2017/00778 ,  A61B2017/22061 ,  A61M2025/0057 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1061 ,  A61M2025/1086 ,  A61M2025/109

摘要： A balloon catheter is provided that may be used to dilate hardened regions of a stenosis on a vessel wall. The balloon catheter is provided with cutting elements that extend along a surface of a balloon. At least one bioactive is present, either on the cutting element, within the interior of the balloon, within the material of the balloon or on an outside surface of the balloon. The bioactive is delivered to the vessel wall upon dilation of the balloon.

公开(公告)号：EP2366362A1

公开(公告)日：2011-09-21

申请号：EP11170043.1

申请日：2007-04-26

申请人： Cook Incorporated ,  William A. Cook Australia Pty. Ltd.

发明人： Chuter, Timothy A. ,  Lawrence-Brown, Michael ,  Hartley, David Ernest

IPC分类号： A61F2/06

摘要： An introducer device for a medical implant comprising a plurality of components for performing a sequence of steps to introduce the medical implant into a desired location and deploying it there wherein selected ones of said components are interconnected by a respective catch arrangement (142) whereby, when one component (104,106,136) has reached a first desired location (150) relative to another component (100), the catch arrangement automatically engages to resist withdrawal of said one component from its first desired location, and when said one component has reached a second desired location (152) relative to the other component, the catch arrangement automatically engages to resist withdrawal of said one component from its second desired location, characterised in that the first desired location is a temporary location and the second desired location is a final location, and in that the catch arrangement engages in a stronger manner at the final location than at the temporary location.

摘要翻译： 一种用于医疗植入物的导引器装置，包括用于执行将所述医疗植入物引入所需位置并将其部署在其上的步骤序列的多个部件，其中所述部件中的选定部件通过相应的捕捉装置（142）互连， 一个部件（104,106,136）相对于另一部件（100）已经达到第一所需位置（150），所述卡扣装置自动接合以阻止所述一个部件从其第一所需位置的退出，并且当所述一个部件达到第二所需位置 位置（152）相对于另一个部件，所述止动装置自动地接合以阻止所述一个部件从其第二期望位置的退出，其特征在于，所述第一期望位置是临时位置，并且所述第二期望位置是最终位置，以及 因为捕捞安排在最后地点比在临时地点更强大 灰。

公开(公告)号：EP2359777A1

公开(公告)日：2011-08-24

申请号：EP11162699.0

申请日：2006-12-22

申请人： Cook Incorporated

发明人： Osborne, Thomas A.

IPC分类号： A61F2/84

CPC分类号： A61F2/95 ,  A61F2002/9511 ,  A61F2002/9517 ,  A61F2002/9665

摘要： A trigger wire release mechanism for selectively releasing a trigger wire (22, 24) from a prosthesis retaining device, includes an elongate body member (36) and a guide member (93, 94) slidably disposed on the body member, the guide member being moveable to disengage the trigger wire (22, 24) from the retaining device, and comprising a knob (100) disposed about the body member. A locking mechanism (120) is provided for limiting the axial position of the guide member (93, 94) along the elongate body member (36). The knob (100) comprises a body portion (102) and a head portion (104), the head portion and the body member having mutually engageable members which can be engaged by rotation of the head portion to prevent the knob from sliding along the body member.

摘要翻译： 用于选择性地从假体保持装置释放触发线（22,24）的触发线释放机构包括细长本体构件（36）和可滑动地设置在本体构件上的导引构件（93,94），导引构件 可移动地将扳机线（22,24）与保持装置分离，并且包括围绕主体构件设置的旋钮（100）。 提供锁定机构（120）以限制引导构件（93,94）沿着细长主体构件（36）的轴向位置。 旋钮（100）包括本体部分（102）和头部分（104），头部分和本体部分具有可相互啮合的部件，它们可以通过旋转头部部分而啮合，以防止旋钮沿着本体滑动 会员。

公开(公告)号：EP2352465A1

公开(公告)日：2011-08-10

申请号：EP09789195.6

申请日：2009-08-24

申请人： Cook Incorporated

发明人： FISCHER, Frank, J. ,  LOWINGER, Johan, M.

IPC分类号： A61F2/88

CPC分类号： A61F2/91 ,  A61F2/88 ,  A61F2/915 ,  A61F2002/828 ,  A61F2002/91566 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0018 ,  A61F2250/0048

摘要： A multi-section tubular device suitable for use as a stent is provided. The multisection tubular device includes a first tubular section (12) having a first end and a second end. A second tubular section (18) is connected to the first end of the first tubular section and a third tubular section (20) is connected to the second end of the first tubular section. The first tubular section is more flexible than the second and third tubular sections. One advantage is that the coiled first tubular section is highly flexible axially, radially, and torsionally, which makes the multi-section tubular device resistant to kinking or fracturing.

摘要翻译： 提供适合用作支架的多节管式装置。 多段管状装置包括具有第一端和第二端的第一管状部分（12）。 第二管状部分（18）连接到第一管状部分的第一端，并且第三管状部分（20）连接到第一管状部分的第二端。 第一管状部分比第二和第三管状部分更灵活。 一个优点是卷绕的第一管状部分在轴向，径向和扭转方面是高度柔性的，这使得多段管状装置耐扭结或压裂。

公开(公告)号：EP2043704B1

公开(公告)日：2011-08-10

申请号：EP07810005.4

申请日：2007-06-28

申请人： Cook Incorporated ,  Med Institute, Inc.

发明人： REYES, Priscilla T. ,  MOORE, William F. ,  RUANE, Patrick ,  MYERS, Randy J.

IPC分类号： A61L31/16

CPC分类号： A61L31/16 ,  A61L2300/416 ,  A61L2300/606

摘要： This disclosure relates to endolumenal medical devices coated with a taxane therapeutic agent in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous paclitaxel, dihydrate paclitaxel, or combinations thereof that provide durable coatings that release paclitaxel over a desired period of time, which can be on the order of hours, days or weeks. Preferred embodiments relate to medical device coatings of paclitaxel, or paclitaxel analogs or derivatives, having one or more polymorph solid forms that provide a prolonged release of paclitaxel within a body vessel without requiring a polymer carrier or barrier layer to achieve the desired rate of paclitaxel elution.

公开(公告)号：EP1871296B1

公开(公告)日：2011-07-20

申请号：EP06750825.9

申请日：2006-04-20

申请人： Cook Incorporated

发明人： PAL, Dharmendra

IPC分类号： A61F2/06

CPC分类号： A61M25/0009 ,  A61F2/95 ,  A61F2002/9517 ,  A61M25/0014 ,  A61M25/0045 ,  A61M25/005 ,  A61M25/0053 ,  A61M25/0069 ,  A61M25/0097 ,  Y10T403/10

摘要： Medical device delivery systems having internal cannulated joints are provided. An internal compression member has a distal mating end portion, an inner guide channel member has first and second end portions defining a channel. An insert body proximal connecting end portion having an exit port operatively couples the compression member mating end portion and insert body distal mating end portion operatively couples the inner member second end portion, the insert body connecting and mating end portions defining a lumen. Alternatively, the insert mating end portion is implanted into the inner member second end portion. Alternatively, the insert mating end portion disposes about the inner member second end portion, and a tubular outer sleeve has a proximal mounting end portion disposed about the insert mating end portion, whereby at least one junction operatively couples the inner member second end portion, insert mating end, and outer sleeve mounting end portion.

公开(公告)号：EP2120795B1

公开(公告)日：2011-07-06

申请号：EP08729867.5

申请日：2008-02-14

申请人： Cook Incorporated

发明人： PAUL, Ram, H. ,  SHIRLEY, Brad

IPC分类号： A61F2/24

CPC分类号： A61F2/2412 ,  A61F2/2418 ,  A61F2/2475 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2250/0036

摘要： One embodiment of the present invention provides an implantable valve prosthesis (100). The valve prosthesis (100) includes a frame (102) defining a lumen extending between a proximal frame end (A) and a distal frame end along a longitudinal axis (y-y' ) / and a first' valve leaflet (104) positioned within the. lumen and having a distal edge (110) attached to the frame (102) and a proximal edge (105) free of the frame (102). The first valve leaflet (104) comprises a first (108) and a second (109) slit extend distally from the proximal edge (106) and defining a free portion (112) of the first valve leaflet (104) between the first (108) and second (109) slits. The first valve leaflet (104) is movable between a first position that allows fluid flow in a first, antegrade, direction and a second position that restricts flow in a second, retrograde direction.

公开(公告)号：EP2320985A1

公开(公告)日：2011-05-18

申请号：EP09790771.1

申请日：2009-07-23

申请人： Cook Incorporated ,  William Cook Europe APS

发明人： AGGERHOLM, Steen ,  BURTON, David, G. ,  BOATMAN, Scott, E.

IPC分类号： A61M25/10 ,  A61M29/02 ,  A61M25/00

摘要： In at least one embodiment of the present invention a balloon catheter is provided. The balloon catheter comprises a shaft having a lumen formed therethrough. Connected to the shaft is an inflatable balloon. The inflatable balloon has a balloon wall defining a balloon interior surface and a balloon exterior surface that is opposite the interior surface. In fluid communication with the balloon wall is the lumen for inflating the balloon to define an inflated state and for collapsing the balloon to define a deflated state. The balloon wall is textured in the deflated state such that the balloon interior surface is spatially registered with the balloon exterior surface. The balloon in the inflated state is tensioned to have a surface roughness substantially less than a surface roughness of the balloon in the deflated state.