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    FLUID DELIVERY SYSTEM, AND ASSOCIATED APPARATUS AND METHOD
    1.
    发明公开
    FLUID DELIVERY SYSTEM, AND ASSOCIATED APPARATUS AND METHOD 审中-公开
    FLUSSIGKEITSABGABESYSTEM，ZUGEHÖRIGEVORRICHTUNG UND VERFAHREN

    公开(公告)号：EP2871940A4

    公开(公告)日：2016-04-13

    申请号：EP13819321

    申请日：2013-07-16

    申请人： FORMULATRIX INC ,  MUKADDAM KABIR ,  ALIMSIJAH PRATOMO

    发明人： MUKADDAM KABIR ,  ALIMSIJAH PRATOMO

    IPC分类号： A01K45/00 ,  B01L3/00 ,  G01N21/53

    CPC分类号： A01K45/007 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2400/0655 ,  B01L2400/0666 ,  G01N21/534 ,  Y10T137/0318 ,  Y10T137/86027

    摘要： A fluid delivery system for an in ovo injection apparatus is provided. Such a fluid delivery system includes a plurality of fluid pumps each having a select valve, a diaphragm valve, and an outlet valve. The select valves are individually controllable such that each select valve is selectively operated via a pneumatic actuator. The diaphragm valves and the outlet valves are commonly operated via respective pneumatic actuators. An input valve is provided for each fluid pump in instances that require high pressure delivery of a fluid substance via the fluid pumps. In such instances, the input valves and the diaphragm valves are commonly controlled via high pressure solenoid valves, while the select valves are selectively controlled and the outlet valves are commonly controlled via low pressure solenoid valves. An associated apparatus and method are also provided.

    摘要翻译： 提供了一种用于进液装置的流体输送系统。 这种流体输送系统包括多个流体泵，每个流体泵具有选择阀，隔膜阀和出口阀。 选择阀是独立可控的，使得每个选择阀通过气动致动器选择性地操作。 隔膜阀和出口阀通常通过相应的气动致动器操作。 在需要通过流体泵高压输送流体物质的情况下，为每个流体泵提供输入阀。 在这种情况下，输入阀和隔膜阀通常通过高压电磁阀控制，而选择阀被选择性地控制，出口阀通过低压电磁阀共同控制。 还提供了一种相关的装置和方法。

    Metering assembly and method of dispensing fluid
    3.
    发明公开
    Metering assembly and method of dispensing fluid 有权
    Dosiervorrichtung und Verfahren zur Abgabe von Fluiden

    公开(公告)号：EP2025405A1

    公开(公告)日：2009-02-18

    申请号：EP08008429.6

    申请日：2008-05-05

    申请人： Formulatrix, Inc.

    发明人： Mukaddam, Kabir James ,  Hu, Jennifer Ezu ,  Stevenson, Jeremy

    IPC分类号： B01L3/00 ,  F04B19/00 ,  F04B43/02 ,  F15C3/04 ,  F15C5/00 ,  F16K99/00

    CPC分类号： F16K99/0001 ,  B01L3/0268 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2300/0816 ,  B01L2300/12 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0638 ,  B01L2400/0655 ,  B33Y80/00 ,  F04B43/02 ,  F04B43/043 ,  F04B43/06 ,  F16K99/0015 ,  F16K99/0028 ,  F16K99/0059 ,  F16K2099/008 ,  Y10T137/87716

    摘要： A metering assembly (10) includes a fluidic chip (300) and metering chambers (510). Selectable outlet valves (610, 620, 630) communicate with each metering chamber to provide a discrete dispensed volume. The valves may be commonly controlled and may be formed as multi-level valves. The valves may be grouped into common substrate valve clusters (600). Purge channels (540) communicate with the metering chambers and controlled purge valves (660) allow reverse flow wash fluid to wash the metering chamber. Pressure ports (330) are employed to actuate the valves. A method of dispensing a fluid from the fluidic chip includes a) selectively filling (or filling) the metering chambers with a selected fluid; and b) outputting (or selectively outputting) the fluid to output locations. The total output volume of fluid dispensed from each metering chamber may be accumulated. The process may be repeated until the accumulated volume equals the desired volume and may be repeated for another fluid from a plurality of different fluids. A microfluidic control apparatus (700, 900) can be used to control fluid flow. The apparatus includes a flexible membrane (704, 904) and a base (702, 902). A substrate having fluid ports (354a, 354b, 954) cooperates with the membrane. The apparatus can have a lip (702, 902) surrounding the membrane. The membrane can be disposed between relatively rigid layers (310, 350).

    摘要翻译： 计量组件（10）包括流体芯片（300）和计量室（510）。 可选择的出口阀（610,620,630）与每个计量室连通以提供离散的分配体积。 这些阀可以是一般控制的并且可以形成为多级阀。 阀可以被分组成公共基板阀组（600）。 吹扫通道（540）与计量室连通，并且受控的清洗阀（660）允许反向洗涤流体洗涤计量室。 压力端口（330）用于致动阀。 从流体芯片分配流体的方法包括：a）用选定的流体选择性地填充（或填充）计量室; 以及b）将流体输出（或选择性地输出）到输出位置。 可以累积从每个计量室分配的流体的总输出体积。 该过程可以重复直到累积体积等于所需体积，并且可以针对来自多种不同流体的另一流体重复该过程。 可以使用微流控制装置（700,900）来控制流体流动。 该装置包括柔性膜（704,904）和底座（702,902）。 具有流体端口（354a，354b，954）的基板与膜配合。 该装置可以具有围绕膜的唇缘（702,902）。 膜可以设置在相对刚性的层（310,350）之间。

    MICROFLUIDIC DEVICE
    5.
    发明公开
    MICROFLUIDIC DEVICE 有权

    公开(公告)号：EP2969215A1

    公开(公告)日：2016-01-20

    申请号：EP14714061.0

    申请日：2014-03-07

    申请人： Formulatrix, Inc.

    发明人： YAMANA, Kabir, James ,  YAMANA-HAYES, Sean ,  STEVENSON, Jeremy ,  YOUNG, Stephen

    IPC分类号： B01L3/00 ,  B01L7/00

    摘要： Microfluidic devices of the present disclosure relate to quick and inexpensive microfluidic manipulation/handling. A number of channels may be supplied with fluid ingredient(s). In some embodiments, a number of protrusions as well as a sealing material may be disposed adjacent to the channels. When the channels are supplied with fluid ingredient(s), the channels may be partitioned into a number of separate cavities that are fluidly isolated from one another. For instance, a sealing material may be compressed so as to deform into the channels, obstructing fluid flow. In some embodiments, the channels supply fluid ingredients to a number of pre-formed cavities. Once the cavities are supplied with fluid ingredient, channels connecting the cavities may be sealed off; that is, the cavities may be subject to fluid isolation. When appropriate, contents within reaction chambers may be subject to further processing (e.g., thermal cycling, various analyses).

    摘要翻译： 本公开的微流体装置涉及快速且便宜的微流体操纵/处理。 许多通道可以供应流体成分。 在一些实施例中，多个突起以及密封材料可以设置在通道附近。 当通道供应有流体成分时，通道可以被分隔成多个彼此流体隔离的单独腔体。 例如，密封材料可以被压缩以便变形成通道，阻碍流体流动。 在一些实施例中，通道将流体成分供应到多个预成型的腔体。 一旦腔体被供应流体成分，连接腔体的通道可被密封; 也就是说，空腔可能会受到流体隔离的影响。 适当时，反应室内的内容物可经受进一步处理（例如，热循环，各种分析）。

    FLUID DELIVERY SYSTEM OF AN IN OVO INJECTION APPARATUS
    6.
    发明公开
    FLUID DELIVERY SYSTEM OF AN IN OVO INJECTION APPARATUS 审中-公开
    爱尔兰内陆爱国者

    公开(公告)号：EP3155264A1

    公开(公告)日：2017-04-19

    申请号：EP15805828.9

    申请日：2015-04-27

    申请人： Formulatrix, Inc.

    发明人： HESSLER, Thomas Matthew ,  YAMANA, Kabir James

    IPC分类号： F04B43/073

    CPC分类号： A01K45/007 ,  F04B43/02

    摘要： A fluid delivery system implemented within an in ovo injection apparatus is disclosed, wherein the fluid delivery system includes a plurality of membrane valves. In particular, the fluid delivery system includes a diaphragm valve that is used to meter out a precise volume of a treatment substance liquid. Further, the diaphragm valve includes certain standoff features on the surface thereof for reducing or entirely preventing the adhesion of the diaphragm to adjacent surfaces when left idle for an extended period of time, as well as an arrangement of fluid channels in the surface thereof for reducing or entirely preventing the trapping of liquid between the diaphragm and adjacent surfaces. The fluid delivery system includes features contributing to optimized flow characteristics.

    摘要翻译： 公开了一种在液体注射装置内实施的流体输送系统，其中流体输送系统包括多个膜阀。 特别地，流体输送系统包括用于计量精确量的处理物质液体的隔膜阀。 此外，隔膜阀在其表面上包括一些间隔特征，用于在长时间闲置时减少或完全防止隔膜粘附到相邻表面，以及在其表面中布置流体通道以减少 或完全防止在隔膜和相邻表面之间捕获液体。 流体输送系统包括有助于优化的流动特性的特征。

    FLUID DELIVERY SYSTEM, AND ASSOCIATED APPARATUS AND METHOD
    8.
    发明公开
    FLUID DELIVERY SYSTEM, AND ASSOCIATED APPARATUS AND METHOD 审中-公开
    流体输送系统以及相关装置和方法

    公开(公告)号：EP2871940A1

    公开(公告)日：2015-05-20

    申请号：EP13819321.4

    申请日：2013-07-16

    申请人： Formulatrix, Inc. ,  Mukaddam, Kabir ,  Alimsijah, Pratomo

    发明人： MUKADDAM, Kabir ,  ALIMSIJAH, Pratomo

    IPC分类号： A01K45/00

    CPC分类号： A01K45/007 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2400/0655 ,  B01L2400/0666 ,  G01N21/534 ,  Y10T137/0318 ,  Y10T137/86027

    摘要： A fluid delivery system for an in ovo injection apparatus is provided. Such a fluid delivery system includes a plurality of fluid pumps each having a select valve, a diaphragm valve, and an outlet valve. The select valves are individually controllable such that each select valve is selectively operated via a pneumatic actuator. The diaphragm valves and the outlet valves are commonly operated via respective pneumatic actuators. An input valve is provided for each fluid pump in instances that require high pressure delivery of a fluid substance via the fluid pumps. In such instances, the input valves and the diaphragm valves are commonly controlled via high pressure solenoid valves, while the select valves are selectively controlled and the outlet valves are commonly controlled via low pressure solenoid valves. An associated apparatus and method are also provided.

    摘要翻译： 提供了一种用于卵内注射装置的流体输送系统。 这种流体输送系统包括多个流体泵，每个流体泵具有选择阀，隔膜阀和输出阀。 选择阀是独立可控的，使得每个选择阀通过气动致动器选择性地操作。 隔膜阀和出口阀通常通过相应的气动致动器进行操作。 在需要通过流体泵高压输送流体物质的情况下，为每个流体泵提供输入阀。 在这种情况下，输入阀和隔膜阀通常通过高压电磁阀来控制，而选择阀被选择性地控制，并且出口阀通常通过低压电磁阀被控制。 还提供了相关的装置和方法。

    Metering assembly and method of dispensing fluid
    9.
    发明公开
    Metering assembly and method of dispensing fluid 有权
    计量组件和分配流体的方法

    公开(公告)号：EP2027924A1

    公开(公告)日：2009-02-25

    申请号：EP08008435.3

    申请日：2008-05-05

    申请人： Formulatrix, Inc.

    发明人： Mukaddam, Kabir James ,  Hu, Jennifer Ezu ,  Stevenson, Jeremy

    IPC分类号： B01L3/00 ,  F04B19/00 ,  F04B43/02 ,  F15C3/04 ,  F15C5/00 ,  F16K99/00

    CPC分类号： F16K99/0001 ,  B01L3/0268 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2300/0816 ,  B01L2300/12 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0638 ,  B01L2400/0655 ,  B33Y80/00 ,  F04B43/02 ,  F04B43/043 ,  F04B43/06 ,  F16K99/0015 ,  F16K99/0028 ,  F16K99/0059 ,  F16K2099/008 ,  Y10T137/87716

    摘要： A metering assembly (10) includes a fluidic chip (300) and metering chambers (510). Selectable outlet valves communicate with each metering chamber to provide a discrete dispensed volume. The valves may be commonly controlled and may be formed as multi-level valves. The valves may be grouped into common substrate valve clusters (600). Purge channels (540) communicate with the metering chambers and controlled purge valves (660) allow reverse flow wash fluid to wash the metering chamber. Pressure ports (330) are employed to actuate the valves. A method of dispensing a fluid from the fluidic chip includes a) selectively filling (or filling) the metering chambers with a selected fluid; and b) outputting (or selectively outputting) the fluid to output locations. The total output volume of fluid dispensed from each metering chamber may be accumulated. The process may be repeated until the accumulated volume equals the desired volume and may be repeated for another fluid from a plurality of different fluids. A microfluidic control apparatus (700, 900) can be used to control fluid flow. The apparatus includes a flexible membrane (704, 904) and a base (702, 902). A substance having fluid ports (354a, 354b, 954) cooperates with the membrane. The apparatus can have a lip (702, 902) surrounding the membrane. The membrane can be disposed between relatively rigid layers (310, 350).

    摘要翻译： 计量组件（10）包括流体芯片（300）和计量腔室（510）。 可选择的出口阀与每个计量室连通以提供不连续的分配体积。 这些阀可以被共同控制并且可以被形成为多级阀。 这些阀可以被分组为共同的基底阀组（600）。 清洗通道（540）与计量腔室连通并且受控清洗阀（660）允许反向流动清洗流体来清洗计量腔室。 使用压力端口（330）来致动阀。 从流体芯片分配流体的方法包括a）用选择的流体选择性地填充（或填充）计量腔室; 和b）输出（或选择性地输出）流体到输出位置。 可以累积从每个计量室分配的流体的总输出量。 该过程可以重复，直到累积体积等于期望体积，并且可以针对来自多种不同流体的另一种流体重复该过程。 微流体控制装置（700,900）可用于控制流体流动。 该设备包括柔性膜（704,904）和基部（702,902）。 具有流体端口（354a，354b，954）的物质与膜协作。 该装置可以具有围绕膜的唇部（702,902）。 膜可以设置在相对刚性的层（310,350）之间。