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1.发明公开
公开(公告)号：EP2955174A4
公开(公告)日：2016-09-28
申请号：EP13874809
申请日：2013-12-10
发明人： LI SONG , XIAO JUNHAI , ZHAO MINGMING , ZHONG WU , WANG LILI , ZHENG ZHIBING , XIE YUNDE , LI XINGZHOU , ZHAO GUOMING , ZHOU XINBO , WANG XIAOKUI , CHEN WEI
IPC分类号： C07D307/33 , A61K31/635 , A61P31/04
CPC分类号： C07D307/33 , A61K31/365 , A61K45/06
摘要： Disclosed are a derivative of homoserine lactone represented by formula I, and a preparation method and use thereof. The compound has a bacterial quorum-sensing regulatory effect, and can be used for prevention and/or treatment of a disease caused by a bacterial infection.
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公开(公告)号：EP2952509A4
公开(公告)日：2016-06-22
申请号：EP13874396
申请日：2013-12-10
发明人： LI SONG , XIAO JUNHAI , ZHAO MINGMING , ZHONG WU , WANG LILI , ZHENG ZHIBING , XIE YUNDE , LI XINGZHOU , ZHAO GUOMING , ZHOU XINBO , WANG XIAOKUI , CHEN WEI
IPC分类号： C07D263/26 , A61K31/421 , A61P31/04
CPC分类号： C07D263/26 , A61K31/421 , A61K45/06
摘要： The invention relates to a compound of formula I, and a preparation method and use thereof. The compound has a bacterial quorum-sensing regulatory effect, and can be used for prevention and/or treatment of a disease caused by a bacterial infection.
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3.发明公开(1S, 2S, 3S, 4R)-3-Ý(1S)-1-ACETYLAMINO-2-ETHYL-BUTYL¨-4-GUANIDINO-2- HYDROXYL-CYCLOPENTYL-1-CARBOXYLIC ACID HYDRATES AND PHARMACEUTICAL USES THEREOF 审中-公开（1S，2S，3S，4R）-3 - [（1S）-1-乙酰氨基-2-乙基 - 丁基] -4-胍基-2-羟基 - 环戊烯-1-碳酸钠在IHRE PHARMAZEUCHSCHE VERWENDUNG
公开(公告)号：EP2186795A4
公开(公告)日：2014-05-07
申请号：EP08800493
申请日：2008-08-13
发明人： LI SONG , ZHONG WU , ZHENG ZHIBING , ZHOU XINBO , XIAO JUNHAI , XIE YUNDE , WANG LILI , LI XINGZHOU , ZHAO GUOMING , WANG XIAOKUI , LIU HONGYING
IPC分类号： C07C279/16 , A61K31/155 , A61P11/00 , A61P31/12
CPC分类号： C07C279/16 , C07B2200/07 , C07C277/06 , C07C277/08 , C07C2601/08
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4.发明公开SUBSTITUTED DIPHENYLAMINES AS INHIBITORS OF REVERSE TRANSCRIPTASE, PROCESS OF PREPARING THEM AND USE THEREOF 有权取代的二苯胺ALS逆转录酶抑制剂，METHOD FOR THEIR其应用
公开(公告)号：EP2213650A4
公开(公告)日：2014-04-02
申请号：EP08840721
申请日：2008-10-07
发明人： XIE LAN , QIN BINGJIE , LEE KOU-HSIUNG
IPC分类号： C07C217/92 , A61K31/136 , A61P31/18 , C07C255/58 , C07C255/59 , C07D307/46
CPC分类号： C07C255/58 , C07C217/92 , C07C255/59 , C07D307/46
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5.发明公开N-ARYL UNSATURATED FUSED RING TERTIARY AMINE COMPOUND, PREPARATION METHOD THEREOF AND ANTITUMOR APPLICATION THEREOF 审中-公开N-芳基不饱和第三纪阿明有关的稠环，用于生产及其用途抗肿瘤
公开(公告)号：EP2857393A4
公开(公告)日：2015-12-23
申请号：EP13798070
申请日：2013-05-30
发明人： XIE LAN , WANG XIAOFENG , LEE KUO-HSIUNG
IPC分类号： C07D401/04 , A61K31/47 , A61K31/4709 , A61K31/517 , A61K31/538 , A61K31/55 , A61P35/00 , C07D215/20 , C07D403/04 , C07D413/04
CPC分类号： C07D473/40 , C07D215/20 , C07D401/04 , C07D403/04 , C07D413/04 , C07D473/00 , C07D473/32 , C07D473/34
摘要： The present invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, its preparation method, a pharmaceutical composition comprising the compound, and its use in manufacture of a medicament for treatment of a disease or disorder, wherein R 1 , R 2 , R 5 , R 6 , X, Y, Q, W, n 1 and n 2 are defined as those stated in the description.
摘要翻译： 本发明涉及式I的化合物或其药学上可接受的盐，其制备方法，药物组合物包含化合物，及其在制备用于治疗疾病或病症的药物中的用途，worin R 1，R 2 中，R 5，R 6，X，Y，Q，W，n 1和n 2如所陈述的那些在说明书中所定义。
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公开(公告)号：EP2805947A4
公开(公告)日：2015-05-27
申请号：EP13738361
申请日：2013-01-15
发明人： LI SONG , WANG YING , XIAO JUNHAI , MA DALONG , GONG HONGWEI , QI HUI , WANG LILI , LING XIAOMEI , ZHENG ZHIBING , ZHANG YANG , ZHONG WU , LI MEINA , XIE YUNDE , XU ENQUAN , LI XINGZHOU , MA JING , ZHAO GUOMING , ZHOU XINBO , WANG XIAOKUI , LIU HONGYING
IPC分类号： C07D403/14 , A61K31/506 , A61K31/519 , A61P11/06 , A61P17/00 , A61P29/00 , A61P37/00 , C07D239/50 , C07D403/12 , C07D417/12
CPC分类号： C07D471/04 , C07D239/50 , C07D401/12 , C07D403/12 , C07D403/14 , C07D417/12
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7.发明公开1-[(4-HYDROXYPRIDIN-4-YL) METHYL]PYRIDINE-2(1H)-ONE DERIVATIVES, PREPARATION METHODS AND USES THEREOF 审中-公开1 - [（4- HYDROXYPRIDIN -4-基）甲基]吡啶-2（1H） - 酮衍生物，用于生产及其用途
公开(公告)号：EP2570410A4
公开(公告)日：2014-01-08
申请号：EP11780040
申请日：2011-04-08
发明人： LI YUNFENG , YANG RIFANG , ZHANG YOUZHI , LI YONGZHEN , JIN ZENGLING , LI PENG , YUAN LI , YUN LIUHONG , ZHAO NAN , ZHANG CHENG , XU XIAODAN , ZHAO RUSHENG , CHEN HONGXIA , XUE RUI , QIN JUANJUAN , WANG ZHENZHEN , YAO JIAZHI
IPC分类号： C07D401/06 , A61K31/4545 , A61P25/00 , A61P25/04 , A61P25/18 , A61P25/24 , A61P25/28
CPC分类号： C07D401/06
摘要： Provided are N-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2( 1H )-one derivatives represented by formula I, stereoisomers, pharmaceutically acceptable salts or solvates thereof. The above compounds have the dual activities of 5-hydroxytryptamine 1A receptor ligand and selective serotonin reuptake inhibitor. The preparation methods of the above compounds, the uses of these compounds for the prevention or treatment of nervous system diseases related to 5-hydroxytryptamine system dysfunction and the pharmaceutical compositions containing these compounds are also provided.
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8.发明公开2-ARYL IMIDAZO[1,2-A]PYRIDINE-3-ACETAMIDE DERIVATIVES, PREPARATION METHODS AND USE THEREOF 有权2-芳基 - 咪唑并[1,2-a]吡啶-3-乙酰胺衍生物，用于生产和使用
公开(公告)号：EP2586780A4
公开(公告)日：2013-11-20
申请号：EP11797579
申请日：2011-06-09
发明人： YANG RI FANG , LI YUN FENG , LI YONG ZHEN , ZHAO NAN , YUN LIU HONG , QIN JUAN JUAN , FENG ZHONG YAO , ZHANG YOU ZHI
IPC分类号： C07D471/04 , A61K31/437 , A61P25/00
CPC分类号： C07D471/04
摘要： Disclosed are 2-arylimidazo[1,2-a]pyridine-3-acetamide derivatives represented by formula I, their tautomer, racemate or optical isomer, their pharmaceutically acceptable salt, or their solvates, wherein R 1 , R 2 , R 3 and R 4 are defined as in the specification. Preparation methods of said compounds and use of said compounds in treating and/or preventing central nervous system disease associated with TSPO functional disorder
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公开(公告)号：EP2005945A4
公开(公告)日：2012-12-19
申请号：EP06775361
申请日：2006-08-11
发明人： LI SONG , ZHONG WU , XIAO JUNHAI , XIE YUNDE , LI XINGZHOU , CUI HAO , ZHENG ZHIBING
IPC分类号： A61K9/16 , A61K31/215 , A61P31/12
CPC分类号： A61K31/215 , A61K9/0056 , A61K9/0095 , A61K9/141 , A61K9/1623 , A61K9/1635 , A61K9/1652
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10.发明公开
公开(公告)号：EP2447253A4
公开(公告)日：2012-11-14
申请号：EP10791138
申请日：2010-05-27
发明人： LI SONG , XU XIAOQIAN , ZHAO GUOMING , WANG LILI , GUAN HUA , XIAO JUNHAI , ZHONG WU , ZHENG ZHIBING , XIE YUNDE , LI XINGZHOU , WANG XIAOKUI , ZHOU XINBO , LIU HONGYING
IPC分类号： C07D239/20 , A61K31/505 , A61K31/506 , A61P31/12 , C07D401/06 , C07D401/14 , C07D403/06
CPC分类号： C07D239/20 , A61K31/4025 , A61K31/4453 , A61K31/505 , A61K31/506 , A61K45/06 , C07D211/14 , C07D239/28 , C07D239/557 , C07D401/06 , C07D403/06 , A61K2300/00
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