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公开(公告)号：EP4422790A1
公开(公告)日：2024-09-04
申请号：EP22728713.3
申请日：2022-05-09
申请人： Illumina, Inc.
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公开(公告)号：EP4419705A1
公开(公告)日：2024-08-28
申请号：EP22802461.8
申请日：2022-10-18
申请人： Illumina, Inc.
发明人： TSAY, James , KRAFT, Lewis J. , BRUSTAD, Eric M. , LESSARD-VIGER, Mathieu , BRODIN, Jeffrey D. , SUBRAMANIAN, Rohit
IPC分类号： C12Q1/6806
CPC分类号： C12Q1/6806 , C12Q1/6874
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3.发明公开
公开(公告)号：EP4394778A3
公开(公告)日：2024-08-28
申请号：EP24170634.0
申请日：2020-05-15
申请人： Illumina Inc.
发明人： KOSTEM, Emrah
IPC分类号： G01N21/64 , G06F18/2413 , G06V10/82 , G16B30/00 , G16B40/10 , C12Q1/6869 , G06N3/045 , G06N3/048 , G06N3/082 , G06N3/084 , G06N3/088 , G06N5/022 , G06N5/048
CPC分类号： C12Q1/6869 , G01N21/6428 , G01N21/6454 , G06N3/084 , G16B30/00 , G16B40/10 , G06N3/082 , G06N3/088 , G06N5/022 , G06N5/048 , G06V10/82 , G06N3/048 , G06N3/045 , G06F18/24133
摘要： A method of determining tag signals from measured intensities is disclosed, the measured intensities collected by light sensors (206, 208, 210, 212, 214) in a sensor array directed to a sample surface (234), the sample surface (234) including pixel areas (206', 208', 210', 212', 214') and holding a plurality of clusters ( 206A, 206B, 208A, 208B, 210A, 210B, 212A, 212B, 214A, 214B ) during a sequence of sampling events, each light sensor (206, 208, 210, 212, 214) directed to and measuring intensity from one of the pixel areas (206', 208', 210', 212', 214') during each sampling period includes adjustments for background intensity (675) and crosstalk (645) and taking into account signal decay (625) and phasing (623) / pre-phasing. Coefficients for the adjustments can be determined by gradient descent, using as ground truth base calling by the system or by using reliable base calling of well- sample run through the system.
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公开(公告)号：EP3642600B1
公开(公告)日：2024-08-21
申请号：EP19819682.6
申请日：2019-06-12
IPC分类号： G01N21/64 , C12Q1/6869
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公开(公告)号：EP3379319B1
公开(公告)日：2024-08-21
申请号：EP18160347.3
申请日：2018-03-06
IPC分类号： G02B21/24
CPC分类号： G02B21/245 , G02B21/361 , G02B21/002 , G02B21/06 , G02B21/18
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公开(公告)号：EP4413576A1
公开(公告)日：2024-08-14
申请号：EP22800025.3
申请日：2022-10-05
申请人： Illumina, Inc.
发明人： HAMP, Tobias , GAO, Hong , FARH, Kai-How
IPC分类号： G16B20/20
CPC分类号： G16B20/20
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公开(公告)号：EP4405955A1
公开(公告)日：2024-07-31
申请号：EP22789405.2
申请日：2022-09-21
申请人： Illumina, Inc.
IPC分类号： G16B40/20 , C12Q1/6869 , G16B30/00
CPC分类号： C12Q1/6869 , G16B40/20 , G16B30/00
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9.发明公开
公开(公告)号：EP4362030A3
公开(公告)日：2024-07-17
申请号：EP24162764.5
申请日：2017-06-07
申请人： ILLUMINA, INC.
发明人： VAN ROOYEN, Pieter , RUEHLE, Michael , MEHIO, Rami , STONE, Gavin , HAHM, Mark , OJARD, Eric , PTASHEK, Amnon
摘要： A system, method and a computer-readable storage device for improving the accuracy of a variant call by jointly evaluating reads that map to two or more regions of a reference sequence that are homologous are disclosed. The method comprises accessing a joint-pileup including a first pileup of sequence reads that have been aligned to a first region of the reference sequence and at least a second pileup of reads that have been aligned to a second region of the reference sequence, wherein the first region and the second region are homologous with each other; determining a set of candidate variants from the joint-pileup; defining a connection matrix that defines an order of processing of the candidate variants; evaluating, by the one or more computers, each of the candidate variants from the set of candidate variants based on the defined processing order; and generating variant call file that identifies one or more of the candidate variants.
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10.发明授权
公开(公告)号：EP3622089B1
公开(公告)日：2024-07-17
申请号：EP18727517.7
申请日：2018-05-07
IPC分类号： C12Q1/6869 , G16B30/10 , C12N15/10 , C12Q1/6806 , G16B25/20
CPC分类号： C12Q1/6869 , G16B30/00 , G16B25/20 , C12Q1/6806 , G16B30/10
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