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    A METHOD OF COMBINING IMAGES OF A SAMPLE FROM DIFFERENT DIGITAL IMAGING DEVICES AND AN ASSOCIATED SYSTEM
    1.
    发明公开
    A METHOD OF COMBINING IMAGES OF A SAMPLE FROM DIFFERENT DIGITAL IMAGING DEVICES AND AN ASSOCIATED SYSTEM 审中-公开

    公开(公告)号：EP4390497A1

    公开(公告)日：2024-06-26

    申请号：EP22315340.4

    申请日：2022-12-20

    申请人： HyprView

    发明人： Auvray, François

    IPC分类号： G02B21/06 ,  G02B21/10 ,  G02B21/12 ,  G02B21/14 ,  G02B21/36

    CPC分类号： G02B21/367 ,  G02B21/06 ,  G02B21/10 ,  G02B21/12 ,  G02B21/14

    摘要： The invention provides a method of combining images (36,38) of a sample from different digital imaging devices (50), comprising:
    determining an image offset (39) between the different imaging devices, comprising:
    using a first imaging device (50) to capture a first digital image (32) of a calibration symbol (30);
    using a second imaging device (50) to capture a second digital image (34) of the calibration symbol; and
    comparing the position of the first digital image (32) of the calibration symbol with the position of the second digital image (34) of the same calibration symbol, thereby determining the offset (39);

    using the first imaging device (50) to capture a first digital image (36) of a sample (10) with a first imaging modality;
    using the second imaging device (50) to capture a second digital image (38) of the sample with a second imaging modality, different to the first;
    translating the second digital image (38) of the sample by the determined offset (39); and
    superimposing the first digital image (36) of the sample and the translated second digital image (38) of the sample, whereby the first image is in registration with the second image.

    SYSTEMS AND METHODS FOR IMPROVED FOCUS TRACKING USING A LIGHT SOURCE CONFIGURATION
    4.
    发明公开
    SYSTEMS AND METHODS FOR IMPROVED FOCUS TRACKING USING A LIGHT SOURCE CONFIGURATION 审中-公开

    公开(公告)号：EP3376275A1

    公开(公告)日：2018-09-19

    申请号：EP18160348.1

    申请日：2018-03-06

    申请人： Illumina, Inc.

    发明人： Condello, Danilo ,  Prince, Simon ,  O'Shaughnessy, John ,  Sigel, Christophe ,  Arianpour, Ashkan

    IPC分类号： G02B21/24

    CPC分类号： G02B21/02 ,  G02B21/002 ,  G02B21/06 ,  G02B21/18 ,  G02B21/245 ,  G02B21/36

    摘要： Provided herein is an imaging system including a light source; a first focusing lens positioned to focus a beam from the light source to a beam waist at a predetermined location along an optical path of the beam in the imaging system; a beam splitter positioned relative to the first focusing lens to receive the beam from the first focusing lens and to create first and second beams; a second focusing lens positioned to receive the first and second beams output by the beam splitter, to focus the received first and second beams to a spot sized dimensioned to fall within a sample to be image, and further positioned to receive first and second beams reflected from the sample; an image sensor positioned to receive the light beams reflected from the sample; and a roof prism positioned in the optical path between the second focusing lens and the image sensor.

    MICROSCOPE DEVICE WITH A PLURALITY OF SHUTTERS
    5.
    发明授权
    MICROSCOPE DEVICE WITH A PLURALITY OF SHUTTERS 有权

    公开(公告)号：EP2843459B1

    公开(公告)日：2018-08-29

    申请号：EP13780627.9

    申请日：2013-04-24

    申请人： Olympus Corporation

    发明人： ISHII, Yasuko ,  KANEKI, Shinsuke ,  ABE, Masaya ,  IMAZEKI, Koji

    IPC分类号： G02B21/00 ,  G02B21/06 ,  G02B21/16 ,  G02B21/24 ,  G02B21/36

    CPC分类号： G02B21/06 ,  G02B21/0088 ,  G02B21/16 ,  G02B21/24 ,  G02B21/36

    摘要： Provided are a microscope apparatus and a method of controlling an optical unit of the microscope apparatus, which enable correct observation by simple manipulation. A microscope apparatus (100) of the present invention includes: an input unit (24) that receives an input of an operation instruction for shutters (8A, 8B) from a user; a storage unit (25) that stores operation conditions of the shutters (8A, 8B) corresponding to one operation instruction by the input unit (24) to the shutters (8A, 8B); a shutter operation controller (19A, 19B) that controls operations of the shutters (8A, 8B); and a main controller (30) that acquires, from the storage unit (25), operation conditions for the one operation instruction by the input unit (24) to the shutters (8A, 8B) and outputs, based on the acquired operation conditions, control signals to cause the shutters (8A, 8B) to be operated in conjunction with each other, to the shutter operation controllers (19A, 19B).

    FLUORESCENT MICROSCOPIC IMAGING METHOD AND APPARATUS
    9.
    发明公开
    FLUORESCENT MICROSCOPIC IMAGING METHOD AND APPARATUS 审中-公开
    荧光显微成像方法和装置

    公开(公告)号：EP3318865A1

    公开(公告)日：2018-05-09

    申请号：EP16817065.2

    申请日：2016-05-20

    申请人： Shanghai Ruiyu Biotech Co. Ltd.

    发明人： LUO, Puwen ,  XIA, Haohan

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6458 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/061 ,  G01N2201/062 ,  G02B21/06 ,  G02B21/16 ,  G02B21/36

    摘要： A fluorescent microscopic imaging method and apparatus, comprising: according to experiment requirements, illuminating at least one monochromatic fluorescence excitation light source (101) of the same colour from amongst a plurality of monochromatic fluorescence excitation light sources (101) as a target light source, the monochromatic fluorescence excitation light emitted by each monochromatic fluorescence excitation light source (101) being obliquely emitted onto a preset detection area of a sample plate to be detected; on the side of the sample plate to be detected furthest from the target light source, collecting the fluorescence of the particles in the preset detection area excited by the irradiation of the monochromatic fluorescence excitation light emitted by the target light source, and amplifying the preset detection area to a preset multiple; implementing light-filtering processing of the excited fluorescence of the particles in the preset detection area; and acquiring a fluorescent image of the preset detection area. A two-colour mirror is not required, and the fluorescence microscope apparatus therefore has a simple structure and low cost, preventing light energy loss. As the monochromatic fluorescence excitation light is obliquely emitted onto the sample plate to be detected, a small amount of monochromatic fluorescence excitation light is emitted into an objective lens after passing through the sample plate to be detected.

    摘要翻译： 1。一种荧光显微镜成像方法及装置，其特征在于，包括：根据实验要求，从多个单色荧光激发光源（101）中照射至少一个相同颜色的单色荧光激发光源（101）作为目标光源， 每个单色荧光激发光源（101）发出的单色荧光激发光斜向发射到待检样板的预设检测区域上; 在距离目标光源最远的待检测样板侧，收集目标光源发射的单色荧光激发光照射所激发的预设检测区域内的颗粒荧光，并放大预设检测值 面积达到预设倍数; 对所述预设检测区域内的粒子激发荧光进行滤光处理; 并获取预设检测区域的荧光图像。 不需要双色镜，因此荧光显微镜装置结构简单，成本低，防止光能损失。 当单色荧光激发光倾斜地发射到待检样板上时，少量的单色荧光激发光穿过待检样板发射到物镜中。