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1.发明授权METHOD AND APPARATUS FOR MANIPULATING SINGLE CELLS AND SMALL AGGREGATES THEREOF 有权方法和设备，用于处理单个细胞和小骨料THEREOF
公开(公告)号：EP2032262B3
公开(公告)日：2015-12-02
申请号：EP07734717.7
申请日：2007-05-31
CPC分类号： B01L3/50273 , B01L2200/14 , B01L2300/0893 , B01L2400/0424 , B03C5/005 , B03C5/026 , G01N27/44782 , G01N27/44791
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2.发明授权METHOD AND APPARATUS FOR MANIPULATING SINGLE CELLS AND SMALL AGGREGATES THEREOF 有权用于操纵单细胞和小细胞聚集体的方法和设备
公开(公告)号：EP2032262B9
公开(公告)日：2012-08-01
申请号：EP07734717.7
申请日：2007-05-31
CPC分类号： B01L3/50273 , B01L2200/14 , B01L2300/0893 , B01L2400/0424 , B03C5/005 , B03C5/026 , G01N27/44782 , G01N27/44791
摘要： A well, in particular an open well (14) with an upper end having a vertical axis (101), for containing a liquid and particles contained within said liquid, characterized by comprising at least two manipulation electrodes (1, 2, 3, 31, 32, 36, 17, 40, 41) able to be powered by electrical voltages, in particular alternating electrical voltages, so as to manoeuvre particles within the well by means of the dielectrophoretic effect. A platform comprising a plurality of wells as described above and a method for using said well.
摘要翻译： 一个井，尤其是具有垂直轴（101）的上端的开放井（14），用于容纳液体和包含在所述液体内的颗粒，其特征在于包括至少两个操纵电极（1,2,3,41 ，32,36,17,40,41），其能够通过电压，特别是交流电压供电，从而借助于介电泳效应来操纵井内的颗粒。 包括如上所述的多个井的平台以及使用所述井的方法。
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3.发明公开METHOD AND APPARATUS FOR MANIPULATING SINGLE CELLS AND SMALL AGGREGATES THEREOF 有权方法和设备，用于处理单个细胞和小骨料THEREOF
公开(公告)号：EP2032262A2
公开(公告)日：2009-03-11
申请号：EP07734717.7
申请日：2007-05-31
CPC分类号： B01L3/50273 , B01L2200/14 , B01L2300/0893 , B01L2400/0424 , B03C5/005 , B03C5/026 , G01N27/44782 , G01N27/44791
摘要： A well, in particular an open well (14) with an upper end having a vertical axis (101), for containing a liquid and particles contained within said liquid, characterized by comprising at least two manipulation electrodes (1, 2, 3, 31, 32, 36, 17, 40, 41) able to be powered by electrical voltages, in particular alternating electrical voltages, so as to manoeuvre particles within the well by means of the dielectrophoretic effect. A platform comprising a plurality of wells as described above and a method for using said well.
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公开(公告)号：EP2646830A1
公开(公告)日：2013-10-09
申请号：EP11808837.6
申请日：2011-12-05
IPC分类号： G01N33/569 , G01N33/536 , G01N33/543
CPC分类号： G01N33/6854 , G01N33/56972
摘要： Methods and systems for rapid and efficient screening of monoclonal antibodies and antibody-secreting cells, and particularly of single antibody-secreting cells, for both primary and functional characteristics, and particularly cell to cell interactions, in a microfluidic system, in particular an inverted open microwell system, where the particle(s) is not bound to a substrate.
摘要翻译： 用于快速和有效筛选单克隆抗体和抗体分泌细胞，尤其是单抗分泌细胞的方法和系统，用于微流体系统中的初级和功能特征，特别是细胞与细胞相互作用，特别是倒置开放 微孔系统，其中颗粒不与基质结合。
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公开(公告)号：EP2646798A1
公开(公告)日：2013-10-09
申请号：EP11813674.6
申请日：2011-12-05
CPC分类号： G01N15/1404 , B01L3/50273 , B01L3/502792 , B01L3/5088 , B01L2200/0652 , B01L2300/0645 , B01L2300/0829 , B01L2300/0864 , B01L2400/0424 , B03C5/005 , B03C5/022 , B03C5/026 , B03C2201/26 , C12M23/12 , C12M29/10 , C12M41/46 , G01N1/4077 , G01N15/1484 , G01N27/44791 , G01N33/50 , G01N33/5005 , G01N2015/1415 , G01N2015/1481 , G01N2015/149
摘要： An inverted microwell (102) provides rapid and efficient microanalysis system (100) and method for screening of biological particles (128), particularly functional analysis of cells on a single cell basis. The use of an inverted open microwell system (102) permits identification of particles, cells, and biomolecules that may be combined to produce a desired functional effect also functional screening of secreted antibody therapeutic activity as well as the potential to recover cells and fluid, and optionally expand cells, such as antibody secreting cells, within the same microwell.
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6.发明授权METHOD AND APPARATUS FOR MANIPULATING SINGLE CELLS AND SMALL AGGREGATES THEREOF 有权方法和设备，用于处理单个细胞和小骨料THEREOF
公开(公告)号：EP2032262B1
公开(公告)日：2012-02-22
申请号：EP07734717.7
申请日：2007-05-31
CPC分类号： B01L3/50273 , B01L2200/14 , B01L2300/0893 , B01L2400/0424 , B03C5/005 , B03C5/026 , G01N27/44782 , G01N27/44791
摘要： A well, in particular an open well (14) with an upper end having a vertical axis (101), for containing a liquid and particles contained within said liquid, characterized by comprising at least two manipulation electrodes (1, 2, 3, 31, 32, 36, 17, 40, 41) able to be powered by electrical voltages, in particular alternating electrical voltages, so as to manoeuvre particles within the well by means of the dielectrophoretic effect. A platform comprising a plurality of wells as described above and a method for using said well.
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