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    MICROPARTICLE FRACTIONATION APPARATUS, AND METHOD FOR OPTIMIZING FLUID STREAM IN SAID APPARATUS
    4.
    发明授权
    MICROPARTICLE FRACTIONATION APPARATUS, AND METHOD FOR OPTIMIZING FLUID STREAM IN SAID APPARATUS 有权
    MIKROPARTIKELFRAKTIONIERUNGSVORRICHTUNG和方法的流体流动在这个器件优化

    公开(公告)号：EP2696190B1

    公开(公告)日：2016-04-13

    申请号：EP13768656.4

    申请日：2013-02-13

    申请人： Sony Corporation

    发明人： MURAKI Yosuke

    IPC分类号： G01N15/14

    CPC分类号： G01N15/1404 ,  B03C7/003 ,  B03C7/12 ,  B07C5/02 ,  B07C5/344 ,  G01N15/1463 ,  G01N15/1484 ,  G01N2015/1415 ,  G01N2015/1481 ,  G01N2015/149 ,  G06T7/0012

    摘要： There is provided a microparticle sorting device that automatically optimizes a fluid stream. There is provided a microparticle sorting device that includes a voltage supply unit that supplies a driving voltage to a vibratory element that applies vibration to an orifice that produces a fluid stream, a charge unit that imparts charge to at least some droplets ejected from the orifice, deflecting plates, arranged opposing each other with the fluid stream S therebetween, that vary a travel direction of the droplets, and a first image sensor that acquires an image of the droplets passing between the deflecting plates. The microparticle sorting device is equipped with a controller that detects the droplets in the image, sets a standard band corresponding to a width of the droplets before imparting the charge, and controls the driving voltage of the voltage supply unit so as to further decrease a quantity of the droplets detected in areas within a designated number of pixels from the standard band from among the droplets after imparting the charge.

    SYSTEM AND METHOD FOR DEFORMING AND ANALYZING PARTICLES
    5.
    发明公开
    SYSTEM AND METHOD FOR DEFORMING AND ANALYZING PARTICLES 审中-公开
    系统在VERFAHREN ZUM VERFORMEN UNDANALYSIEREN VON TEILCHEN

    公开(公告)号：EP2912434A2

    公开(公告)日：2015-09-02

    申请号：EP13871771.5

    申请日：2013-10-18

    申请人： The Regents of the University of California

    发明人： DI CARLO, Dino ,  GOSSETT, Daniel R. ,  TSE, Henry T.K. ,  CHUNG, Aram

    IPC分类号： G01N15/14 ,  G01N21/64 ,  G01B11/24

    CPC分类号： G01N15/1404 ,  G01N15/1434 ,  G01N15/1436 ,  G01N15/1459 ,  G01N15/147 ,  G01N15/1484 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/50 ,  G01N33/5091 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1415 ,  G01N2015/1495 ,  G01N2021/6439 ,  G06K9/4604 ,  G06T7/0004 ,  G06T7/0016

    摘要： A system for deforming and analyzing particles includes a substrate defining an inlet, and an outlet; a fluidic pathway fluidly coupled to the inlet and the outlet and defining a delivery region upstream of a deformation region configured to deform particles, wherein the fluidic pathway comprises a first branch configured to generate a first flow, and a second branch configured to generate a second flow that opposes the first flow, wherein an intersection of the first flow and the second flow defines the deformation region; a detection module including a sensor configured to generate a morphology dataset characterizing deformation of the particles, and a photodetector configured to generate a fluorescence dataset characterizing fluorescence of the particles; and a processor configured to output an analysis of the plurality of particles based at least in part on the deformation dataset and the fluorescent dataset for the plurality of particles.

    摘要翻译： 用于变形和分析颗粒的系统包括限定入口的基板和出口; 流体连接到入口和出口的流体通路，并且限定被配置成使颗粒变形的变形区域上游的输送区域，其中流体路径包括构造成产生第一流量的第一分支，以及第二分支， 所述第一流与所述第一流相对，其中所述第一流和所述第二流的交点限定所述变形区; 检测模块，其包括被配置为生成表征所述粒子的变形的形态数据集的传感器，以及被配置为产生表征所述粒子的荧光的荧光数据集的光检测器; 以及处理器，被配置为至少部分地基于所述多个粒子的所述变形数据集和所述荧光数据集来输出所述多个粒子的分析。

    DATA CORRECTION METHOD IN FINE PARTICLE MEASURING DEVICE AND FINE PARTICLE MEASURING DEVICE
    7.
    发明公开
    DATA CORRECTION METHOD IN FINE PARTICLE MEASURING DEVICE AND FINE PARTICLE MEASURING DEVICE 审中-公开
    新加坡国立大学

    公开(公告)号：EP2860511A1

    公开(公告)日：2015-04-15

    申请号：EP13800843.8

    申请日：2013-04-03

    申请人： Sony Corporation

    发明人： NITTA Nao ,  IMANISHI Shingo ,  TAKEUCHI Taichi

    IPC分类号： G01N15/14 ,  G01N21/49 ,  G01N21/64

    CPC分类号： G01N21/64 ,  G01B21/00 ,  G01N15/1429 ,  G01N15/1459 ,  G01N21/05 ,  G01N21/21 ,  G01N21/53 ,  G01N21/645 ,  G01N2015/1006 ,  G01N2015/1415

    摘要： To provide a technique capable of highly accurately measure the intensity and the spectrum of fluorescence and scattered light by effectively correcting measurement error that occurs due to variation of flow positions of fine particles in a channel. A data correction method for a fine particle measurement device is provided, which includes an intensity detection procedure capable of detecting light generated from a fine particle by emitting light onto the fine particle flowing through a channel, and obtaining intensity information about the light, a position detection procedure capable of obtaining position information about the fine particle, and a correction procedure for correct ing the intensity information on the basis of the position information. In this data correction method, the position detection procedure is such that a detection device receives light of an S polarization component which is separated from scattered light generated from the fine particle and given astigmatism, and a light reception position of the S polarization component on the detection device is obtained as the position information.

    摘要翻译： 提供一种能够通过有效地校正由于通道中的细颗粒的流动位置的变化而发生的测量误差而能够高精度地测量荧光和散射光的强度和光谱的技术。 提供了一种微粒测量装置的数据校正方法，其包括强度检测程序，其能够通过将光发射到流过通道的细颗粒上来检测由微粒产生的光，并获得关于光的强度信息，位置 能够获得关于微粒的位置信息的检测程序，以及基于位置信息来校正强度信息的校正步骤。 在该数据校正方法中，位置检测步骤使得检测装置接收与由微粒产生的散射光分离的S偏振分量的光和给定的散光，以及S偏振分量的光接收位置 获取检测装置作为位置信息。

    FLOW CYTOMETER WITH DIGITAL HOLOGRAPHIC MICROSCOPE
    8.
    发明公开
    FLOW CYTOMETER WITH DIGITAL HOLOGRAPHIC MICROSCOPE 审中-公开
    流式细胞仪用数字显微镜全息

    公开(公告)号：EP2815227A1

    公开(公告)日：2014-12-24

    申请号：EP13703623.2

    申请日：2013-02-13

    申请人： Ovizio Imaging Systems NV/SA

    发明人： JOORIS, Serge ,  MATHUIS, Philip

    IPC分类号： G01N15/14

    CPC分类号： G01N15/1434 ,  G01N15/1404 ,  G01N15/1459 ,  G01N21/6486 ,  G01N2015/1006 ,  G01N2015/1415 ,  G01N2015/1445 ,  G03H1/0005 ,  G03H1/0443 ,  G03H2001/0033 ,  G03H2001/005

    摘要： The current invention concerns a flow cytometric system and method for observing, analyzing and/or separating objects in a liquid sample, comprising a digital holographic microscope (DHM) and at least one fluidic system, whereby the DHM comprises illumination means, an interferometric system and digital recording means, whereby the fluidic system is capable of guiding said objects through an illumination beam of the illumination means of said DHM, whereby the fluidic system comprises a mechanism for inducing a liquid sample stream through the fluidic system, whereby preferably the fluidic system comprises a stream size controlling device for controlling the transverse dimensions of a liquid sample stream inside said fluidic system, preferably said stream size controlling device is capable of lining up the objects one-by-one or multiple objects at a time in said liquid sample stream.