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1.发明授权
公开(公告)号：EP3201225B1
公开(公告)日：2020-08-19
申请号：EP15848061.6
申请日：2015-10-02
发明人： LIU, Zhonghao , DING, Xunshan
IPC分类号： C07K14/575 , A61K38/22 , A61P3/06 , A61P3/04 , A61P3/10
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公开(公告)号：EP3212226B1
公开(公告)日：2020-03-18
申请号：EP15855147.3
申请日：2015-10-29
发明人： SHEN, Wenyan , LINDHOUT, Darrin , HALDANKAR, Raj , MATERN, Hugo
IPC分类号： A61K39/00 , C07K14/475
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公开(公告)号：EP2726511B1
公开(公告)日：2019-08-07
申请号：EP12807786.4
申请日：2012-06-29
发明人： LING, Lei , LINDHOUT, Darrin, A.
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5.发明公开
公开(公告)号：EP3201225A4
公开(公告)日：2018-05-23
申请号：EP15848061
申请日：2015-10-02
发明人： LIU ZHONGHAO , DING XUNSHAN
IPC分类号： C07K14/575 , A61K38/22 , A61P3/04 , A61P3/06 , A61P3/10
CPC分类号： A61K38/22 , A61P3/04 , A61P3/06 , A61P3/10 , C07K14/575 , C07K2319/00 , C07K2319/30 , C07K2319/31 , C07K2319/50 , G01N33/92
摘要： Methods and compositions for reducing one or more of triglyceride levels, total cholesterol levels and LDL cholesterol levels in a subject are provided. The methods include administering a fragment of ANGPTL8 to a subject having or at risk of developing elevated triglyceride levels, elevated total cholesterol levels and/or elevated LDL cholesterol levels.
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公开(公告)号：EP3212226A1
公开(公告)日：2017-09-06
申请号：EP15855147.3
申请日：2015-10-29
发明人： SHEN, Wenyan , LINDHOUT, Darrin , HALDANKAR, Raj , MATERN, Hugo
IPC分类号： A61K39/00 , C07K14/475
摘要： A complex comprising a GDF15 polypeptide is described. Methods of treating individuals with a metabolism disorder, such as, glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
摘要翻译： 描述了包含GDF15多肽的复合物。 提供了治疗具有代谢障碍例如葡萄糖代谢障碍和/或体重障碍的个体的方法以及与其相关的组合物。
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公开(公告)号：EP2950807A2
公开(公告)日：2015-12-09
申请号：EP14746188.3
申请日：2014-01-27
IPC分类号： A61K38/18
CPC分类号： C07K14/495 , A61K38/00 , A61K38/1841 , C07K14/765 , C07K2319/30 , C07K2319/31
摘要： Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
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公开(公告)号：EP4306165A3
公开(公告)日：2024-04-17
申请号：EP23192402.8
申请日：2012-06-29
CPC分类号： C07K2319/0020130101 , A61K38/00 , A61K38/1825 , A61K31/785 , C07K14/50 , G01N33/5088 , A61P1/18 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P43/00 , A61P5/48 , A61P5/50 , A61P9/08 , A61P9/12 , A61P3/10 , A61K31/14 , A61K31/155
摘要： The invention relates to a fusion of fibroblast growth factor 19 (FGF19) and fibroblast growth factor 21 (FGF21) and its use in the treatment of hyperglycemic condition, insulin resistance, hyperinsulinemia, glucose intolerance, metabolic syndrome, obesity, undesirable body mass, nonalcoholic fatty liver disease (NAFLD) nonalcoholic steatohepatitis (NASH), atherosclerosis and related disorders.
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公开(公告)号：EP3738981A1
公开(公告)日：2020-11-18
申请号：EP20170906.0
申请日：2015-01-23
发明人： MONDAL, Kalyani , LI, Betty, Chan , CHEN, Yu , ARORA, Taruna , MATERN, Hugo , SHEN, Wenyan
摘要： The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.
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公开(公告)号：EP3097122B9
公开(公告)日：2020-11-11
申请号：EP15740600.0
申请日：2015-01-23
发明人： MONDAL, Kalyani , LI, Betty, Chan , CHEN, Yu , ARORA, Taruna , MATERN, Hugo , SHEN, Wenyan
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