-
公开(公告)号：EP1715857A1
公开(公告)日：2006-11-02
申请号：EP04704686.7
申请日：2004-01-23
发明人： KONG, Xianqi , WU, Xinfu , MIGNEAULT, David
IPC分类号： A61K31/155 , A61K31/167 , A61K31/18 , A61K31/4168 , A61P3/10 , A61P5/50 , A61P25/28 , A61P43/00
CPC分类号： A61K31/155 , A61K31/167 , A61K31/18 , A61K31/4168
摘要： The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formula (I), such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited: Formula (I).
-
2.发明公开IMPROVED PHARMACEUTICAL DRUG CANDIDATES AND METHODS FOR PREPARATION THEREOF 有权用于生产1,3-丙二醇，二CONNECTIONS
公开(公告)号：EP1646659A2
公开(公告)日：2006-04-19
申请号：EP04744203.3
申请日：2004-06-21
发明人： KONG, Xianqi , MIGNEAULT, David , WU, Xinfu
IPC分类号： C08C1/00
CPC分类号： C07D207/325 , C07C303/02 , C07C303/22 , C07C303/32 , C07D211/52 , C07D211/64 , C07D211/70 , C07D217/04 , C07D217/10 , C07D221/04 , C07D233/54 , C07D295/088 , C07D453/02 , C07D471/04 , C07D495/04 , C07C309/05 , C07C309/14
摘要： The present invention is directed to methods of preparation of sulfonate derivatized compounds, e.g., 3-amino-l-propanesulfonic acid and 1,3-propanedisulfonic acid disodium salt with increased purity, with reduced potential for toxic by-products, and that are pharmaceutically useful, e.g., for the treatment of amyloidosis.
-
公开(公告)号：EP1937239A2
公开(公告)日：2008-07-02
申请号：EP06842398.7
申请日：2006-10-02
发明人： KONG, Xianqi , LAURIN, Julie
CPC分类号： A61K31/19
摘要： Pharmaceutical compositions and methods for using carboxyalkylsulfonic acids, and pharmaceutically acceptable solvates thereof are described. The compounds of the invention are particularly useful as neuroprotective agents and for the prevention and/or treatment Abeta-amyloid related diseases, including Alzheimer's disease.
-
公开(公告)号：EP1658264A2
公开(公告)日：2006-05-24
申请号：EP04743998.9
申请日：2004-06-21
IPC分类号： C07C309/14
CPC分类号： C07D207/333 , C07C307/02 , C07C309/13 , C07C309/14 , C07C309/15 , C07C309/46 , C07C309/69 , C07C311/32 , C07C311/46 , C07C335/32 , C07C381/02 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D217/04 , C07D257/04 , C07D295/084 , C07D295/088 , C07D453/02 , C07D471/04 , C07F9/1651 , C07F9/2458
摘要： Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-+ related disease.
摘要翻译： 方法，化合物，药物组合物和试剂盒中描述用于治疗或预防淀粉样蛋白相关的+疾病。
-
公开(公告)号：EP1420773A1
公开(公告)日：2004-05-26
申请号：EP02758012.5
申请日：2002-09-03
发明人： CHALIFOUR, Robert J. , KONG, Xianqi , WU, Xinfu , LU, Wenshuo
IPC分类号： A61K31/155
CPC分类号： C07C257/18 , A61K31/155 , A61K31/341 , A61K31/343 , A61K31/4164 , A61K31/4184 , Y02P20/582
摘要： The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formula (X), such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited.
-
公开(公告)号：EP1890685A2
公开(公告)日：2008-02-27
申请号：EP06831844.3
申请日：2006-04-12
发明人： LAURIN, Julie , GARCEAU, Denis
IPC分类号： A61K31/185 , A61P25/28
CPC分类号： A61K31/185 , A61K9/0004 , A61K9/2009 , A61K9/2018 , A61K9/2054 , A61K9/2086 , A61K9/209 , A61K9/2846 , A61K9/2886 , A61K9/485 , A61K9/5047
摘要： Therapeutic formulations and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Therapeutic formulations and methods for preventing or treating amyloidosis and/or amyloid-related disease are also described.
-
公开(公告)号：EP1173480B1
公开(公告)日：2008-01-16
申请号：EP00926599.2
申请日：2000-05-04
CPC分类号： C07K14/4711 , A61K38/00 , Y02A50/406
摘要： The present invention relates to antifibrillogenic agents for inhibiting amyloidosis and/or for cytoprotection for the treatment of amyloidosis disorders. These agents include peptides, isomers thereof and peptidomimetic compounds thereof. These agents comprise a peptide having a sequence identified from the glycosaminoglycan (GAG) binding region and the prot-prot interaction region of the amyloid protein. The peptide has at least one [D] amino acid isomer substitution. The invention also relates to the peptide bound to a label for in vivo imaging of amyloid deposits.
摘要翻译： 本发明涉及用于抑制淀粉样变性和/或用于治疗淀粉样变性病症的细胞保护的抗纤维蛋白原药剂。 这些药剂包括肽，其异构体及其拟肽化合物。 这些药剂包含具有由糖胺聚糖（GAG）结合区和淀粉样蛋白的prot-prot相互作用区鉴定的序列的肽。 该肽具有至少一个[D]氨基酸异构体取代。 本发明还涉及结合至用于淀粉样蛋白沉积物的体内成像的标记的肽。
-
8.发明公开THERAPEUTIC FORMULATIONS FOR THE TREATMENT OF BETA-AMYLOID RELATED DISEASES 审中-公开治疗制剂·对于β-淀粉样蛋白相关疾病的治疗
公开(公告)号：EP1841460A2
公开(公告)日：2007-10-10
申请号：EP05858504.3
申请日：2005-06-17
IPC分类号： A61K45/06
CPC分类号： A61K45/06 , A61K31/185 , A61K31/27 , A61K31/445 , A61K2300/00
摘要： This invention relates to methods and pharmaceutical compositions for treating amyloid-β related diseases, including Alzheimer’s disease. The invention, for example, includes a method of concomitant therapeutic treatment of a subject, comprising administering an effective amount of a first agent and a second agent, wherein said first agent treats an amyloid-β disease, neurodegeneration, or cellular toxicity; and said second agent is a therapeutic drug or nutritive supplement.
-
公开(公告)号：EP1646375A2
公开(公告)日：2006-04-19
申请号：EP04744063.1
申请日：2004-06-21
IPC分类号： A61K31/185 , A61K31/445 , A61K31/495 , A61P25/00 , A61P25/16 , A61P25/28
CPC分类号： A61K31/445 , A61K31/185 , A61K31/495
摘要： The present invention is based, at least in part on the discovery of therapeutic agents capable of preventing, inhibiting or modulating abnormal processing, misfolding or aggregation of protein. The therapeutic agents of the invention may prevent, inhibit or modulate the formation of inclusions. The therapeutic agents of the invention may also be capable of facilitating clearance and/or blocking the cellular toxicity of inclusions to treat or ameliorate disorders characterized by protein aggregation. Compounds which bind to structural motifs commonly found in protein aggregates, such as ß-sheets, would represent strong candidates for such compounds and are therefore desirable.
-
10.发明公开TREATMENT OF AMYLOID- AND EPILEPTOGENESIS-ASSOCIATED DISEASES 审中-公开BEHANDLUNG AMYLOID-UND EPILEPTOGENESIS-ASSOZIIERTER KRANKHEITEN
公开(公告)号：EP1635909A2
公开(公告)日：2006-03-22
申请号：EP04776863.5
申请日：2004-06-21
发明人： KONG, Xianqi , LU, Wenshuo , WU, Xinfu
IPC分类号： A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , A61P27/00 , A61P29/00 , A61K31/185
CPC分类号： C07D239/06 , A61K31/185 , C07C309/14 , C07C309/26 , C07C2601/14 , C07C2602/10 , C07D209/14 , C07D213/38 , C07D233/24 , C07D233/28 , C07D263/10 , C07D263/16 , C07D265/08 , C07D277/10 , C07D277/12 , C07D279/06 , C07D317/58 , C07D333/20 , C07D333/58
摘要： Methods of treating or preventing an amyloid-related disease in a subject by administering to a subject a therapeutic amount of a compound of the invention are described. Also included are methods for inhibiting epileptogenesis in a subject, by administering to a subject an effective amount of an anti-epileptogenic agent. Methods for treating a subject suffering from an epileptogenesis-associated condition, by administering to the subject an effective amount of an anti-epileptogenic agent are also included. Methods for treating convulsions in a subject by administering to the subject an effective amount of a therapeutic amount of a compound of the invention are also described.
摘要翻译： 描述了通过向受试者施用治疗量的本发明化合物来治疗或预防受试者的淀粉样蛋白相关疾病的方法。 还包括通过向受试者施用有效量的抗癫痫发生剂来抑制受试者中癫痫发生的方法。 还包括通过向受试者施用有效量的抗癫痫发生剂来治疗患有癫痫发生相关病症的受试者的方法。 还描述了通过向受试者施用有效量的治疗量的本发明化合物来治疗受试者惊厥的方法。
-
-
-
-
-
-
-
-
-
搜索结果
22 条记录 (耗时 0.032 秒)
