公开(公告)号：EP1420773A1

公开(公告)日：2004-05-26

申请号：EP02758012.5

申请日：2002-09-03

申请人： Neurochem (International) Limited ,  Chalifour, Robert J. ,  Kong, Xianqi ,  Wu, Xinfu

发明人： CHALIFOUR, Robert J. ,  KONG, Xianqi ,  WU, Xinfu ,  LU, Wenshuo

IPC分类号： A61K31/155

CPC分类号： C07C257/18 ,  A61K31/155 ,  A61K31/341 ,  A61K31/343 ,  A61K31/4164 ,  A61K31/4184 ,  Y02P20/582

摘要： The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formula (X), such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited.

公开(公告)号：EP1572129A2

公开(公告)日：2005-09-14

申请号：EP03757414.2

申请日：2003-06-09

申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ,  GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. ,  Tidwell, Richard R. ,  Boykin, David ,  Chalifour, Robert J. ,  Kong, Xianqi

发明人： TIDWELL, Richard R. ,  BOYKIN, David ,  CHALIFOUR, Robert, J. ,  KONG, Xianqi ,  WU, Xinfu ,  LU, Wenshuo

IPC分类号： A61K7/00

CPC分类号： A61K31/4184 ,  A61K31/155 ,  A61K31/341 ,  A61K31/343 ,  A61K31/4164 ,  C07C257/18 ,  C07D235/24 ,  C07D235/30 ,  C07D263/32 ,  C07D403/12

摘要： The present invention relates to the use of amidine compounds in the treatment of amyloid related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formulae, such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited. Formula I, Formula II, Formula III.

公开(公告)号：EP1572129A4

公开(公告)日：2007-03-28

申请号：EP03757414

申请日：2003-06-09

申请人： UNIV NORTH CAROLINA ,  UNIV GEORGIA STATE RES FOUND ,  TIDWELL RICHARD R ,  BOYKIN DAVID ,  CHALIFOUR ROBERT J ,  KONG XIANQI

发明人： TIDWELL RICHARD R ,  BOYKIN DAVID ,  CHALIFOUR ROBERT J ,  KONG XIANQI ,  WU XINFU ,  LU WENSHUO

IPC分类号： A61K31/155 ,  A61K31/341 ,  A61K31/343 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/421 ,  A61P3/10 ,  A61P25/28 ,  C07C257/18 ,  C07D233/06 ,  C07D235/24 ,  C07D235/30 ,  C07D263/30 ,  C07D263/32 ,  C07D403/12

CPC分类号： A61K31/4184 ,  A61K31/155 ,  A61K31/341 ,  A61K31/343 ,  A61K31/4164 ,  C07C257/18 ,  C07D235/24 ,  C07D235/30 ,  C07D263/32 ,  C07D403/12

摘要： The present invention relates to the use of amidine compounds in the treatment of amyloid related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formulae, such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited. Formula I, Formula II, Formula III.