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    NASAL ADMINISTRATION
    2.
    发明公开
    NASAL ADMINISTRATION 审中-公开

    公开(公告)号：EP3546000A1

    公开(公告)日：2019-10-02

    申请号：EP19173055.5

    申请日：2006-01-19

    申请人： Optinose AS

    发明人： DJUPESLAND, Per, Gisle ,  HAFNER, Roderick, Peter

    IPC分类号： A61M15/08

    摘要： A delivery device for delivery of substance to the central nervous system (CNS) of a subject, the delivery device comprising: a nosepiece unit for insertion into a nasal airway of a subject and comprising an outlet unit which includes a nozzle for delivering substance into the nasal airway of the subject; and a substance supply unit which is operable to deliver a dose of substance to the nozzle; wherein the delivery device is configured such that at least 30 % of the dose as initially deposited in the nasal airway is deposited in an upper posterior region of the nasal airway, thereby providing a CNS concentration of the substance, and hence CNS effect, which is significantly greater than that which would be predicted from a counterpart blood plasma concentration of the substance. Sumatriptan or its pharmaceutically-acceptable derivatives or analogues for use in the treatment of migraine.

    INTRANASAL ADMINISTRATION
    4.
    发明公开
    INTRANASAL ADMINISTRATION 审中-公开
    内部管理

    公开(公告)号：EP3220989A1

    公开(公告)日：2017-09-27

    申请号：EP15798061.6

    申请日：2015-11-19

    申请人： Optinose AS

    发明人： DJUPESLAND, Per Gisle ,  SHELDRAKE, Colin David

    IPC分类号： A61M15/08 ,  A61M15/00

    摘要： A delivery device for and method of modulating a condition relating to sodal cognition and/or behaviour in a human subject using oxytocin, non-peptide agonists thereof and/or antagonists thereof, comprising: providing a nosepiece to a first nasal cavity of the subject; and providing a supply unit for administering less than 24 IU of oxytocin, non-peptide agonists thereof and/or antagonists thereof through the nosepiece to an upper region posterior of the nasal valve which is innervated by the trigeminal nerve.

    摘要翻译： 一种使用催产素，其非肽激动剂和/或其拮抗剂调节与人类受试者中的认知和/或行为有关的状况的递送装置和方法，包括：将鼻托提供给受试者的第一鼻腔; 并且提供供应单元，用于通过喷头将少于24IU的催产素，其非肽激动剂和/或其拮抗剂施用至由三叉神经支配的鼻瓣后部的上部区域。

    NASAL DELIVERY
    9.
    发明公开
    NASAL DELIVERY 审中-公开

    公开(公告)号：EP2136865A2

    公开(公告)日：2009-12-30

    申请号：EP08736896.5

    申请日：2008-04-07

    申请人： Optinose AS

    发明人： DJUPESLAND, Per, Gisle ,  SHELDRAKE, Colin, David

    IPC分类号： A61M15/08

    摘要： A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece for fitting to a nostril of a subject, wherein the nosepiece comprises a tip element which includes a delivery aperture from which substance is in use delivered into the nasal cavity, and the tip element is at least in part tapered such as to be inclined to a longitudinal axis of the nosepiece, with the delivery aperture extending both laterally across the tip element and along a longitudinal extent of the tip element; a nozzle through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity; and a delivery unit for delivering substance through the nozzle of the nosepiece.

    摘要翻译： 1。一种用于将物质递送至受试者的鼻腔的鼻递送装置和方法，所述递送装置包括：用于装配到受试者的鼻孔的鼻形件（17），其中所述鼻形件（17）包括末端元件（25） 其包括递送到鼻腔中的使用物质的递送孔（26），并且末端元件（25）至少部分地逐渐变细以便相对于鼻形件（17）的纵向轴线倾斜，其中 输送孔（28）横向延伸穿过尖端元件（25）并沿着尖端元件（25）的纵向延伸; 使用物质的喷嘴（35）优选地基本上轴向地延伸到鼻形件（17）的纵向轴线，至相应的鼻腔; 以及用于通过喷嘴（17）的喷嘴（35）输送物质的输送单元（37）。

    NASAL DELIVERY DEVICES
    10.
    发明公开
    NASAL DELIVERY DEVICES 审中-公开
    NASALE ABGABEVORRICHTUNGEN

    公开(公告)号：EP2004266A2

    公开(公告)日：2008-12-24

    申请号：EP07735003.1

    申请日：2007-03-23

    申请人： Optinose AS

    发明人： DJUPESLAND, Per, Gisle

    IPC分类号： A61M15/08 ,  A61M15/00

    CPC分类号： A61M15/08 ,  A61M11/00 ,  A61M15/0003 ,  A61M15/0021 ,  A61M15/0065 ,  A61M15/009 ,  A61M15/0098 ,  A61M2202/04 ,  A61M2202/064 ,  A61M2205/075 ,  A61M2210/0618 ,  A61M2210/0625

    摘要： A delivery device for and method of delivering a dose of substance for systemic uptake to a nasal cavity of a subject, the delivery device comprising: a nosepiece unit for insertion into a nasal cavity of a subject and comprising an outlet unit which includes at least one nozzle for delivering substance for systemic uptake substantially only to surfaces in one or both of the anterior region and an anterior section of the posterior region of the nasal cavity of the subject; and a substance supply unit which is operable to deliver a dose of substance to the at least one nozzle.

    摘要翻译： 一种递送装置，用于递送一定剂量的物质以全身吸收到受试者的鼻腔，所述递送装置包括：用于插入受试者鼻腔的鼻梁单元，并包括出口单元，该出口单元包括至少一个 用于输送物质的喷嘴，其基本上仅仅用于受试者鼻腔的后部区域的前部区域和前部区域中的一个或两个中的表面; 以及物质供应单元，其可操作以将剂量的物质输送到所述至少一个喷嘴。