摘要:
A nasal delivery device for delivering a substance to the nasal airway of a subject, comprising a delivery unit for delivering a gas flow and substance to one of the nostrils of the subject; wherein the delivery unit comprises a nosepiece which includes an outlet through which the gas flow and substance is in use delivered to the one nostril and a sealing member for providing a fluid tight seal between the outlet and the one nostril; wherein, during closure of the oropharyngeal velum of the subject, the delivery unit is configured to deliver the gas flow at a driving pressure to flow around the posterior margin of the nasal septum and out of the other nostril of the subject.
摘要:
A nasal delivery device for delivering a substance to the nasal airway of a subject, comprising a delivery unit for delivering a gas flow and substance to one of the nostrils of the subject; wherein the delivery unit comprises a nosepiece which includes an outlet through which the gas flow and substance is in use delivered to the one nostril and a sealing member for providing a fluid tight seal between the outlet and the one nostril; wherein, during closure of the oropharyngeal velum of the subject, the delivery unit is configured to deliver the gas flow at a driving pressure to flow around the posterior margin of the nasal septum and out of the other nostril of the subject.
摘要:
The present invention provides an air-intake device for delivering a substance to the nasal cavity of a subject which comprises: a container for containing the substance; a nosepiece and a mouthpiece extending from the device, for placement in proximity to the nose and mouth of the subject, respectively; a valve mechanically connectable to the container, with an active configuration and an inactive configuration; and, a trigger mechanism to reconfigure the valve from the active configuration to the inactive configuration, and vice versa. The trigger mechanism is activated by intaking air through the mouthpiece by the subject. Drawing air from the mouthpiece reconfigures the valve from its inactive configuration to its active configuration for a predetermined period of time and delivers the substance from the device to a nasal cavity of the subject.
摘要:
A nasal delivery device for delivering particulate substance to the nasal airway of a subject, the delivery device comprising: a mouthpiece unit (209) which includes a mouthpiece (247) through which the subject in use exhales; a nosepiece unit (205) which includes a nosepiece (241) for fitting to a nostril of the subject; a substance-supply unit (211) which is configured to receive a container (C) containing particulate substance, the container (C) comprising a main body part (215) and first and second bearing support parts (217, 217) at the respective ends of the body part (215), and operable to provide a metered amount of substance in fluid communication with the mouthpiece and nosepiece units (209, 205), such that an exhalation air flow delivered through the substance-supply unit (211) entrains the substance; and a housing (203) which supports the mouthpiece unit (209), the nosepiece unit (205) and the substance-supply unit (211); wherein the substance-supply unit (211) includes a container-receiving member (251) which is movably disposed to the housing (203) between an open position for enabling loading of a container (C) thereinto and a closed position in which the container (C) is contained within the housing (203), and the container-receiving member (251) includes a cavity (253) which defines an air flow channel between the mouthpiece and nosepiece units (209, 205), such that an air flow is delivered therethrough on exhalation by the subject through the mouthpiece (247), and a support section for supporting the container (C) in the cavity (253) which includes first and second container supports (255, 255) for rotatably supporting the respective support parts (217, 217) of the container (C).
摘要:
A delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: at least one nosepiece unit (21) for insertion into one nasal cavity of a subject and comprising a nosepiece (25) for fitting to the respective nostril of the subject; and at least one delivery unit (23) which is operative to deliver a substance through the at least one nosepiece unit into the one nasal cavity of the subject, wherein the at least one delivery unit includes a substance supply unit (27) for delivering a substance and an actuation unit (29) which is operable to actuate the substance supply unit, either automatically or manually, in response to nasal exhalation or at least attempted nasal exhalation by the subject.
摘要:
A method of high-speed processing and monitoring of a product, such as a pharmaceutical powder or tablet, comprises: moving the product (C) past an inspection station; illuminating at least a portion of the product with light; spectrally filtering a first portion of light carrying invormation about the product, o.g., transmitted or reflected light, by passing said first portion through at least one multivariate optical element (148) and detecting said filtered light with a first detector (152),- detecting a deflected second portion of said light with a second detector (156); and determining at least one selected property of the product based on the detector outputs.
摘要:
A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a substance supply unit for supplying a dose of substance to be delivered to the nasal cavity of the subject, the substance supply unit including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit; and a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain substance from the container chamber and deliver the same through the nosepiece, and at least one temperature modifier for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.