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公开(公告)号：EP2680830A2
公开(公告)日：2014-01-08
申请号：EP12751765.4
申请日：2012-02-28
CPC分类号： A61K31/14 , A61K9/10 , A61K9/16 , A61K31/15 , A61K31/20 , A61K31/23 , A61K31/685 , A61K2300/00
摘要： Urinary incontinence is treated by administration of pharmaceutical compositions containing at least one nitrone spin trap such as α-phenyl t-butyl nitrone (PBN) and derivatives thereof. Preferred compositions and methods of treatment further comprise at least one adjunctive ingredient including fatty acid esters of ascorbic acid such as ascorbyl palmitate and ascorbyl stearate, and polyenylphosphatidylcholine.
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公开(公告)号：EP2519246A1
公开(公告)日：2012-11-07
申请号：EP10779178.2
申请日：2010-11-09
CPC分类号： A61K38/063
摘要： Topical compositions to treat inflammatory skin conditions such as psoriasis comprise an effective amount of S-acyl glutathione derivative and a carrier. Methods for treating inflammatory skin conditions such as psoriasis comprise applying a composition containing S-acyl glutathione derivative in a dermatologically acceptable carrier to skin tissue. The acyl group is a saturated or unsaturated aliphatic C1
2 -C
24 group, preferably an unsaturated C
16 - C
24 group, most preferably an unsaturated C
18 group. In particularly preferred embodiments, the acyl group is a linoleoyl group.摘要翻译： 治疗炎症性皮肤病如牛皮癣的局部组合物包含有效量的S-酰基谷胱甘肽衍生物和载体。 治疗炎性皮肤病如银屑病的方法包括将含有S-酰基谷胱甘肽衍生物的组合物在皮肤病学可接受的载体中施用于皮肤组织。 酰基是饱和或不饱和脂族C12-C24基团，优选不饱和C16-C24基团，最优选不饱和C18基团。 在特别优选的实施方案中，酰基是亚油酰基。
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3.发明公开TREATMENT OF SKIN WOUNDS USING POLYENYLPHOSPHATIDYLCHOLINE AND ALKANOLAMINES 审中-公开皮肤伤口的治疗中使用多烯磷脂和烷醇胺
公开(公告)号：EP1581172A4
公开(公告)日：2006-01-11
申请号：EP03808620
申请日：2003-12-31
IPC分类号： A61K8/41 , A61K8/55 , A61K31/13 , A61K31/133 , A61K31/685 , A61P17/00 , A61P17/10 , A61Q19/00 , A61Q19/08 , A61K7/48 , A61P17/02
CPC分类号： A61K31/133 , A61K8/41 , A61K8/553 , A61K31/13 , A61K31/685 , A61Q19/00 , A61Q19/08 , Y10S514/847 , A61K2300/00
摘要： Polyenylphosphatidylcholine in combination with an alkanolamine are topically applied to treat skin wounds, promote healing, and minimize scar formation. Typical compositions contain from about 0.25% to about 12% of a polyenylphosphatidylcholine preparation obtained from natural sources such as soybean oil which contains at least about 25% by weight, preferably about 40% or more, dilinoeoylphosphatidylcholine, and from about 0.1% to about 10% by weight of an alkanolamine such as ethylaminoethanol, methylaminoethanol, dimethylaminoethanol, isopropanolamine, triethanolamine, isopropanoldimethylamine ehtylethanolamine, 2-butanolamine, choline, serine, or mixtures thereof. Dimethylaminoethanol is a particularly preferred alkanolamine. Tyrosine is an adjunct ingredient in many embodiments.
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公开(公告)号：EP0801565B1
公开(公告)日：2005-10-19
申请号：EP95914884.2
申请日：1995-03-27
IPC分类号： A61K31/355 , A61K31/34 , A61K7/48
CPC分类号： A61Q19/08 , A61K8/498 , A61K8/676 , A61K8/678 , A61K31/35 , A61K31/355 , A61K31/60 , A61Q5/00 , A61Q17/04 , Y10S514/847 , A61K2300/00
摘要： A method for the prevention and/or treatment of skin or hair damage, particularly inflammation and aging of skin and hair damage from sunlight and chemicals, in which a tocotrienol, a derivative thereof or a vitamin E preparation enriched with tocotrienol or a tocotrienol derivative, is topically applied to the exposed or affected skin or hair areas. A fat-soluble fatty acid ester of ascorbic acid such as palmityl ascorbate is preferably applied with the tocotrienol in association with a dermatologically acceptable carrier.
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公开(公告)号：EP1039891B1
公开(公告)日：2005-08-17
申请号：EP98958031.1
申请日：1998-11-16
IPC分类号： A61K31/19 , A61K31/16 , A61K31/385 , A61P17/02
CPC分类号： A61Q19/00 , A61K8/365 , A61K8/4986 , A61K31/385 , A61K45/06 , A61K31/335 , A61K31/19 , A61K2300/00
摘要： Scar tissue is reduced or inhibited by application of a composition containing lipoic acid and/or a lipoic acid derivative such as dihydrolipoic acid, a lipoic or dihydrolipoic acid ester, a lipoic or dihydrolipoic acid amide, a lipoic or dihydrolipoic acid salt, and mixtures of any of these. Some compositions further comprise α-hydroxy acids or acid derivatives such as glycolic and/or lactic acid, fatty acid esters of ascorbic acid such as ascorbyl palmitate, and/or tocotrienol. In some embodiments, a silicone gel sheet with added lipoic acid and/or a lipoic acid derivative and optional other ingredients is topically applied to scar tissue to diminish them.
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公开(公告)号：EP1341535A2
公开(公告)日：2003-09-10
申请号：EP01273547.8
申请日：2001-12-12
IPC分类号： A61K31/34
CPC分类号： A61Q19/02 , A61K8/4973 , A61K31/365
摘要： Skin whitening compositions contain α-hydroxytetronic acid or α-hydroxytetronic derivative, and, in some cases, hydroquinone, an α-hydroxy acid such as glycolic acid, and a fatty acid ester of ascorbic acid such as ascorbyl palmitate.
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公开(公告)号：EP0944310A1
公开(公告)日：1999-09-29
申请号：EP97947537.0
申请日：1997-11-17
CPC分类号： A61K8/37 , A61K8/345 , A61K8/39 , A61K8/676 , A61K8/97 , A61K2800/522 , A61Q19/00 , A61Q19/001 , A61Q19/08
摘要： Fatty acid esters of ascorbic acid, particularly saturated fatty acid esters such as ascorbyl palmitate, their salts, ascorbic acid and its salts are solubilized in large amounts, e.g., up to about 25 % by weight, and stabilized using special solvent systems. Useful solvents include polyethylene glycol, ethoxydiglycol, propylene glycol, butylene glycol, propylene carbonate, glycerin, a capric glyceride, a caprylic glyceride, an alkyl lactate, an alkyl adipate, an isosorbide, and mixtures thereof. Preferred dermatological compositions made using these solvents with ascorbic acid and/or at least one of its derivatives also include dimethylaminoethanol, tyrosine, proline, cystine, a penetration enhancer such as oleic acid, urea or mixtures thereof, and at least one natural and/or chemical antioxidant. Natural antioxidants that contain at least about 50 % polyphenols and 50 % catachins such as grape seed or green tea extracts are employed in some embodiments.
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公开(公告)号：EP1401418A4
公开(公告)日：2006-05-24
申请号：EP02739748
申请日：2002-06-06
申请人： PERRICONE NICHOLAS V
发明人： PERRICONE NICHOLAS V
IPC分类号： A61N1/36 , A61K8/00 , A61K8/02 , A61K8/30 , A61K8/33 , A61K8/36 , A61K8/365 , A61K8/38 , A61K8/41 , A61K8/44 , A61K8/49 , A61K8/64 , A61K8/67 , A61K9/70 , A61K31/13 , A61K31/131 , A61K31/133 , A61K31/14 , A61K31/19 , A61K31/195 , A61K31/198 , A61K31/375 , A61K31/381 , A61K31/385 , A61K38/00 , A61K45/06 , A61P17/10 , A61Q3/02 , A61Q5/00 , A61Q5/02 , A61Q17/00 , A61Q19/00
CPC分类号： A61Q19/00 , A61K8/0208 , A61K8/38 , A61K8/41 , A61K8/44 , A61K8/4986 , A61K31/13 , A61K31/131 , A61K31/133 , A61K31/195 , A61K31/385 , A61K45/06 , A61K2800/75 , A61K2800/83 , A61Q5/02 , A61Q17/00 , A61K2300/00
摘要： Skin, hair and nails are treated by topical application of compositions containing an alkanolamine such as dimethylaminoethanol to increase smoothness and surface uniformity. Application to the skin visibly decreases pore size, treats or prevents acne, diminishes or prevents cutaneous scar tissue, and/or provides a pretreatment prior to applying electrical pulses sufficient to contract subcutaneous muscles underlying the skin. Application to the hair, fingernails or toenails increases elasticity, enhances shine, and provides emolliency to keratin. Alkanolamine compositions contain at least one other adjunct ingredient such as tyrosine, lipoic acid, an alpha -hydroxy acid, or a fatty acid ester of ascorbic acid in most embodiments.
摘要翻译： 通过局部施用含有链烷醇胺如二甲基氨基乙醇的组合物来处理皮肤，头发和指甲，以增加平滑度和表面均匀性。 对皮肤的应用可以明显地减少孔径，治疗或预防痤疮，减少或防止皮肤瘢痕组织，和/或在施加足以收缩皮下皮下肌肉的电脉冲之前提供预处理。 对头发，指甲或脚趾甲的应用增加弹性，增强光泽，并为角蛋白提供润肤性。 在大多数实施方案中，链烷醇胺组合物含有至少一种其它辅助成分，例如酪氨酸，硫辛酸，α-羟基酸或抗坏血酸的脂肪酸酯。
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公开(公告)号：EP1549279A2
公开(公告)日：2005-07-06
申请号：EP03770593.6
申请日：2003-09-26
CPC分类号： A61Q17/04 , A61K8/26 , A61K2800/412 , A61Q1/02
摘要： Dispersions containing from about 0.5% to about 30% by weight dispersed microfine calcined alumina, stainless steel, or gold particles typically having particle size of less than about 5µ, more narrowly 1µ or less, suspended in a cosmetically acceptable carrier are useful as sunblocks for skin and hair while simultaneously providing treatments that render skin and hair smoother, more uniform, lustrous, visually appealing and healthier-looking.
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公开(公告)号：EP0944310B1
公开(公告)日：2005-04-06
申请号：EP97947537.3
申请日：1997-11-17
CPC分类号： A61K8/37 , A61K8/345 , A61K8/39 , A61K8/676 , A61K8/97 , A61K2800/522 , A61Q19/00 , A61Q19/001 , A61Q19/08
摘要： Fatty acid esters of ascorbic acid, particularly saturated fatty acid esters such as ascorbyl palmitate, their salts, ascorbic acid and its salts are solubilized in large amounts, e.g., up to about 25 % by weight, and stabilized using special solvent systems. Useful solvents include polyethylene glycol, ethoxydiglycol, propylene glycol, butylene glycol, propylene carbonate, glycerin, a capric glyceride, a caprylic glyceride, an alkyl lactate, an alkyl adipate, an isosorbide, and mixtures thereof. Preferred dermatological compositions made using these solvents with ascorbic acid and/or at least one of its derivatives also include dimethylaminoethanol, tyrosine, proline, cystine, a penetration enhancer such as oleic acid, urea or mixtures thereof, and at least one natural and/or chemical antioxidant. Natural antioxidants that contain at least about 50 % polyphenols and 50 % catachins such as grape seed or green tea extracts are employed in some embodiments.
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