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1.发明公开TREATMENT OF SKIN WOUNDS USING POLYENYLPHOSPHATIDYLCHOLINE AND ALKANOLAMINES 审中-公开皮肤伤口的治疗中使用多烯磷脂和烷醇胺
公开(公告)号：EP1581172A4
公开(公告)日：2006-01-11
申请号：EP03808620
申请日：2003-12-31
IPC分类号： A61K8/41 , A61K8/55 , A61K31/13 , A61K31/133 , A61K31/685 , A61P17/00 , A61P17/10 , A61Q19/00 , A61Q19/08 , A61K7/48 , A61P17/02
CPC分类号： A61K31/133 , A61K8/41 , A61K8/553 , A61K31/13 , A61K31/685 , A61Q19/00 , A61Q19/08 , Y10S514/847 , A61K2300/00
摘要： Polyenylphosphatidylcholine in combination with an alkanolamine are topically applied to treat skin wounds, promote healing, and minimize scar formation. Typical compositions contain from about 0.25% to about 12% of a polyenylphosphatidylcholine preparation obtained from natural sources such as soybean oil which contains at least about 25% by weight, preferably about 40% or more, dilinoeoylphosphatidylcholine, and from about 0.1% to about 10% by weight of an alkanolamine such as ethylaminoethanol, methylaminoethanol, dimethylaminoethanol, isopropanolamine, triethanolamine, isopropanoldimethylamine ehtylethanolamine, 2-butanolamine, choline, serine, or mixtures thereof. Dimethylaminoethanol is a particularly preferred alkanolamine. Tyrosine is an adjunct ingredient in many embodiments.
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公开(公告)号：EP0801565B1
公开(公告)日：2005-10-19
申请号：EP95914884.2
申请日：1995-03-27
IPC分类号： A61K31/355 , A61K31/34 , A61K7/48
CPC分类号： A61Q19/08 , A61K8/498 , A61K8/676 , A61K8/678 , A61K31/35 , A61K31/355 , A61K31/60 , A61Q5/00 , A61Q17/04 , Y10S514/847 , A61K2300/00
摘要： A method for the prevention and/or treatment of skin or hair damage, particularly inflammation and aging of skin and hair damage from sunlight and chemicals, in which a tocotrienol, a derivative thereof or a vitamin E preparation enriched with tocotrienol or a tocotrienol derivative, is topically applied to the exposed or affected skin or hair areas. A fat-soluble fatty acid ester of ascorbic acid such as palmityl ascorbate is preferably applied with the tocotrienol in association with a dermatologically acceptable carrier.
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公开(公告)号：EP1039891B1
公开(公告)日：2005-08-17
申请号：EP98958031.1
申请日：1998-11-16
IPC分类号： A61K31/19 , A61K31/16 , A61K31/385 , A61P17/02
CPC分类号： A61Q19/00 , A61K8/365 , A61K8/4986 , A61K31/385 , A61K45/06 , A61K31/335 , A61K31/19 , A61K2300/00
摘要： Scar tissue is reduced or inhibited by application of a composition containing lipoic acid and/or a lipoic acid derivative such as dihydrolipoic acid, a lipoic or dihydrolipoic acid ester, a lipoic or dihydrolipoic acid amide, a lipoic or dihydrolipoic acid salt, and mixtures of any of these. Some compositions further comprise α-hydroxy acids or acid derivatives such as glycolic and/or lactic acid, fatty acid esters of ascorbic acid such as ascorbyl palmitate, and/or tocotrienol. In some embodiments, a silicone gel sheet with added lipoic acid and/or a lipoic acid derivative and optional other ingredients is topically applied to scar tissue to diminish them.
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公开(公告)号：EP1341535A2
公开(公告)日：2003-09-10
申请号：EP01273547.8
申请日：2001-12-12
IPC分类号： A61K31/34
CPC分类号： A61Q19/02 , A61K8/4973 , A61K31/365
摘要： Skin whitening compositions contain α-hydroxytetronic acid or α-hydroxytetronic derivative, and, in some cases, hydroquinone, an α-hydroxy acid such as glycolic acid, and a fatty acid ester of ascorbic acid such as ascorbyl palmitate.
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公开(公告)号：EP0944310A1
公开(公告)日：1999-09-29
申请号：EP97947537.0
申请日：1997-11-17
CPC分类号： A61K8/37 , A61K8/345 , A61K8/39 , A61K8/676 , A61K8/97 , A61K2800/522 , A61Q19/00 , A61Q19/001 , A61Q19/08
摘要： Fatty acid esters of ascorbic acid, particularly saturated fatty acid esters such as ascorbyl palmitate, their salts, ascorbic acid and its salts are solubilized in large amounts, e.g., up to about 25 % by weight, and stabilized using special solvent systems. Useful solvents include polyethylene glycol, ethoxydiglycol, propylene glycol, butylene glycol, propylene carbonate, glycerin, a capric glyceride, a caprylic glyceride, an alkyl lactate, an alkyl adipate, an isosorbide, and mixtures thereof. Preferred dermatological compositions made using these solvents with ascorbic acid and/or at least one of its derivatives also include dimethylaminoethanol, tyrosine, proline, cystine, a penetration enhancer such as oleic acid, urea or mixtures thereof, and at least one natural and/or chemical antioxidant. Natural antioxidants that contain at least about 50 % polyphenols and 50 % catachins such as grape seed or green tea extracts are employed in some embodiments.
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公开(公告)号：EP1549279A2
公开(公告)日：2005-07-06
申请号：EP03770593.6
申请日：2003-09-26
CPC分类号： A61Q17/04 , A61K8/26 , A61K2800/412 , A61Q1/02
摘要： Dispersions containing from about 0.5% to about 30% by weight dispersed microfine calcined alumina, stainless steel, or gold particles typically having particle size of less than about 5µ, more narrowly 1µ or less, suspended in a cosmetically acceptable carrier are useful as sunblocks for skin and hair while simultaneously providing treatments that render skin and hair smoother, more uniform, lustrous, visually appealing and healthier-looking.
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公开(公告)号：EP0944310B1
公开(公告)日：2005-04-06
申请号：EP97947537.3
申请日：1997-11-17
CPC分类号： A61K8/37 , A61K8/345 , A61K8/39 , A61K8/676 , A61K8/97 , A61K2800/522 , A61Q19/00 , A61Q19/001 , A61Q19/08
摘要： Fatty acid esters of ascorbic acid, particularly saturated fatty acid esters such as ascorbyl palmitate, their salts, ascorbic acid and its salts are solubilized in large amounts, e.g., up to about 25 % by weight, and stabilized using special solvent systems. Useful solvents include polyethylene glycol, ethoxydiglycol, propylene glycol, butylene glycol, propylene carbonate, glycerin, a capric glyceride, a caprylic glyceride, an alkyl lactate, an alkyl adipate, an isosorbide, and mixtures thereof. Preferred dermatological compositions made using these solvents with ascorbic acid and/or at least one of its derivatives also include dimethylaminoethanol, tyrosine, proline, cystine, a penetration enhancer such as oleic acid, urea or mixtures thereof, and at least one natural and/or chemical antioxidant. Natural antioxidants that contain at least about 50 % polyphenols and 50 % catachins such as grape seed or green tea extracts are employed in some embodiments.
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公开(公告)号：EP1509243A1
公开(公告)日：2005-03-02
申请号：EP03756329.3
申请日：2003-06-02
IPC分类号： A61K38/28
CPC分类号： A61K47/24 , A61J3/07 , A61K9/0014 , A61K9/02 , A61K9/06 , A61K9/127 , A61K9/1277 , A61K31/56 , A61K38/02 , A61K38/11 , A61K38/23 , A61K38/24 , A61K38/27 , A61K38/28 , A61K38/31 , A61K38/56 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/34 , C07K14/62 , Y10S514/806 , Y10S514/807 , Y10S514/808 , Y10S514/866 , Y10S514/97
摘要： The present invention relates to compositions and methods for transdermal drug delivery comprising formulating a phosphatidylcholine carrier composition containing the drug and applying the composition to the skin.
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公开(公告)号：EP0751760B1
公开(公告)日：2001-07-25
申请号：EP93901140.9
申请日：1992-12-21
CPC分类号： A61Q19/004 , A61K8/365 , A61K31/19 , A61Q17/04
摘要： A method for the therapeutic treatment or prevention of radiation-induced skin damage, particularly ultraviolet-induced skin burn (e.g., sunburn), in which an alpha-hydroxy acid, or a derivative thereof, is topically applied to the affected skin areas. Glycolic acid is employed in a preferred embodiment.
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公开(公告)号：EP0944310A4
公开(公告)日：2001-01-10
申请号：EP97947537
申请日：1997-11-17
发明人： PERRICONE NICHOLAS V , POTINI CHIM
IPC分类号： C07D307/62 , A61K8/00 , A61K8/23 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/41 , A61K8/44 , A61K8/49 , A61K8/67 , A61K8/86 , A61K8/97 , A61K31/375 , A61P17/00 , A61Q1/00 , A61Q1/04 , A61Q1/10 , A61Q19/00 , A61Q19/08 , A01N43/08 , A61K7/48 , A61K31/34
CPC分类号： A61K8/37 , A61K8/345 , A61K8/39 , A61K8/676 , A61K8/97 , A61K2800/522 , A61Q19/00 , A61Q19/001 , A61Q19/08
摘要： Fatty acid esters of ascorbic acid, particularly saturated fatty acid esters such as ascorbyl palmitate, their salts, ascorbic acid and its salts are solubilized in large amounts, e.g., up to about 25 % by weight, and stabilized using special solvent systems. Useful solvents include polyethylene glycol, ethoxydiglycol, propylene glycol, butylene glycol, propylene carbonate, glycerin, a capric glyceride, a caprylic glyceride, an alkyl lactate, an alkyl adipate, an isosorbide, and mixtures thereof. Preferred dermatological compositions made using these solvents with ascorbic acid and/or at least one of its derivatives also include dimethylaminoethanol, tyrosine, proline, cystine, a penetration enhancer such as oleic acid, urea or mixtures thereof, and at least one natural and/or chemical antioxidant. Natural antioxidants that contain at least about 50 % polyphenols and 50 % catachins such as grape seed or green tea extracts are employed in some embodiments.
摘要翻译： 抗坏血酸的脂肪酸酯，特别是饱和脂肪酸酯如抗坏血酸棕榈酸酯，其盐，抗坏血酸及其盐以大量溶解（例如高达约25％重量），并使用特殊溶剂体系稳定。 有用的溶剂包括聚乙二醇，乙氧基二甘醇，丙二醇，丁二醇，碳酸丙烯酯，甘油，癸酸甘油酯，辛酸甘油酯，乳酸烷基酯，己二酸烷基酯，异山梨醇及其混合物。 使用这些溶剂与抗坏血酸和/或其至少一种衍生物制备的优选皮肤病学组合物还包括二甲基氨基乙醇，酪氨酸，脯氨酸，胱氨酸，渗透增强剂如油酸，尿素或其混合物，以及至少一种天然和/或 化学抗氧剂。 在一些实施方案中使用含有至少约50％多酚和50％猫爪角素（例如葡萄籽或绿茶提取物）的天然抗氧化剂。
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