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公开(公告)号：EP2036543A1
公开(公告)日：2009-03-18
申请号：EP07721533.3
申请日：2007-06-22
发明人： ZHANG, Shunnan , YANG, Jianhui , DONG, Lina , ZHANG, Hongbo , BAI, Xiaolin , SUN, Yan , LI, Ting
IPC分类号： A61K9/16 , A61K36/00 , A61K47/38 , A61K47/04 , A61K47/34 , A61P25/00 , A61P3/10 , A61P9/10 , A61P31/00 , A61P1/16
CPC分类号： A61K9/5078 , A61K9/1676 , A61K9/1682 , A61K9/5089 , A61K36/233
摘要： A pharmaceutical granule whose shape is spherical or sphere-like shape with a bulk density of 0.6-1.3 g/ml and a dissolution time of 0.5-5 minutes, which is prepared as follows: mother granules are filled into a fluidized-bed as bed charge; active pharmaceutical ingredients are prepared into a suspension or solution whose viscosity is adjusted to 6.0-9.8 Mpa.S with viscosity adjusting agent; then it is sprayed onto surface of said mother granule to obtain final granule.
摘要翻译： 形状为球形或球状形状的药物颗粒，其堆积密度为0.6-1.3g / ml，溶解时间为0.5-5分钟，其制备如下：将母体颗粒填充到流化床中作为床 收费; 将活性药物成分制成悬浮液或溶液，其粘度用粘度调节剂调节至6.0-9.8Mpa·s; 然后将其喷雾到所述母粒的表面上以获得最终的颗粒。
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2.发明公开PHARMACEUTICAL COMPOSITION CONTAINING CHENOPODIUM AMBROSIOIDES EXTRACT AND ITS PREPARATION PROCESS AND APPLICATION 有权含有CHEN CHEN藜提取物的药物组合物及其制备方法和应用
公开(公告)号：EP1982705A8
公开(公告)日：2008-12-10
申请号：EP06840721.2
申请日：2006-12-29
发明人： WEI, Feng , YE, Zhengliang , GAO, Jun , LUO, Chongnian , LI, Dekun , CHEN, Jianming , ZHU, Yonghong , XIONG, Junfeng , ZHENG, Xiaoli , ZHANG, Guangming , ZHAO, Ying
IPC分类号： A61K31/01 , A61K36/185 , A61K9/00 , A61P1/04
CPC分类号： A61K31/357 , A61K9/0095 , A61K9/1623 , A61K9/1652 , A61K9/2054 , A61K9/2059 , A61K9/2846 , A61K9/2866 , A61K9/4866 , A61K31/01 , A61K31/015 , A61K36/185 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/24 , A61K47/26 , A61K47/44
摘要： The present invention relates to plant extracts, specifically, the extracts of Chinese medicine Chenopodium ambrosioides L. and the composition comprising thereof. The extracts of Chinese medicine Chenopodium ambrosioides L. are prepared by conventional methods for the extraction of volatile oil, and can be used to treat Helicobacter Pylori-induced diseases of digestive system, such as gastritis, gastric ulcer, etc., with easy availability of raw materials, simple preparations, prominent effects, and less side-effect.
摘要翻译： 本发明涉及植物提取物，特别是中药藜（Chenopodium ambrosioides L.）的提取物及其组合物。 中草药藜提取物采用常规提取挥发油的方法制备，可用于治疗幽门螺杆菌引起的消化系统疾病，如胃炎，胃溃疡等，易于获得 原料制备简单，效果显着，副作用少。
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3.发明公开
公开(公告)号：EP1829519A1
公开(公告)日：2007-09-05
申请号：EP05817628.0
申请日：2005-12-05
发明人： YAN, Xijun N0.1, Liaohedong Road , ZHANG, Boli N0.1, Liaohedong Road , GUO, Zhixin N0.1, Liaohedong Road , ZHU, Guoguang N0.1, Liaohedong Road , YE, Zhengliang N0.1, Liaohedong Road , WEI, Feng N0.1, Liaohedong Road , LUO, Ruizhi N0.1, Liaohedong Road
IPC分类号： A61K6/00
CPC分类号： A61K36/704 , A61K36/258 , A61K36/537 , A61K36/734 , A61K2300/00
摘要： The present invention discloses a pharmaceutical composition comprising Polygonum multiflorum Thunb, which comprises Polygonum multiflorum Thunb, Fructus Crataegi, Salvia miltiorrhiza Bunge and Radix Notoginseng. If needed, the pharmaceutical composition may comprise the pharmaceutically acceptable carriers. The weight ratio of Polygonum multiflorum Thunb, Salvia miltiorrhiza Bunge, Fructus Crataegi and Radix Notoginseng in the present composition is as follows: 10 to 20 parts of Polygonum multiflorum Thunb, 5 to 15 parts of Salvia miltiorrhiza Bunge, 10 to 20 parts of Fructus Crataegi and 1 to 10 parts of Radix Notoginseng. Also, the present invention discloses the methods for preparing the composition, including directly pulverizing the medicines into powder to produce the composition or preparing the medicines into the extracts and then make the extracts into drugs. The composition of the present invention has an effect of lowering blood lipid, and therefore can be used in preparation of drugs for treatment and/or prevention of hyperlipidemia. The present invention also discloses a method to treat and/or prevent hyperlipidemia.
摘要翻译： 本发明盘松动的药物组合物，包含何首乌，其包括何首乌，山楂，丹参和三七。 如果需要，所述药物组合物可包含药学上可接受的载体。 何首乌，丹参，山楂和三七的本发明组合物的重量比为如下：10至20份何首乌，5至15份丹参，10至20份山楂的 和1至10份三七的。 所以，本发明盘松散组合物的制备，包括直接粉碎药物成粉末，以产生所述组合物或制备的药剂进入提取物，然后使提取物到药物的方法。 本发明的组合物具有以实现降低血脂的，并且因此可以在制备的药物用于治疗和/或预防高脂血症中使用。 因此，本发明光盘松的方法治疗和/或预防高脂血症。
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4.发明公开NEW SALVIANOLIC ACID COMPOUND L, PREPARATION METHOD AND USE THEREOF 有权NEURSALVIANOLSÄUREVERBINDUNGL，ZUBEREITUNGSVERFAHREN UND VERWENDUNG
公开(公告)号：EP2415749A1
公开(公告)日：2012-02-08
申请号：EP10758037.5
申请日：2010-03-29
发明人： ZHOU, Shuiping , LI, Wei , JIN, Yuanpeng , MA, Xiaohui , HAN, Jianping , CUI, Hongfang , LUO, Xuejun , CHEN, Xiaopeng
IPC分类号： C07C59/52 , C07C51/42 , A61K31/192 , A61P9/00
CPC分类号： C07C69/732
摘要： The present invention relates to a new compound of salvianolic acid L, its preparation method, a pharmaceutical composition containing the salvianolic acid L, and its use for preparing a medicament for treating cardio-cerebrovascular diseases.
摘要翻译： 本发明涉及一种新的丹酚酸L化合物，其制备方法，含有丹酚酸L的药物组合物及其制备用于治疗心脑血管疾病的药物的用途。
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5.发明授权CHINESE MEDICINAL COMPOSITIONS FOR TREATING HEADACHE, FORMULATIONS AND PROCESSES FOR PREPARATION THEREOF 有权中国临床康复组合物头痛的BEHANLDUNG，并处理其配方
公开(公告)号：EP1930020B1
公开(公告)日：2011-06-01
申请号：EP06775453.1
申请日：2006-08-22
发明人： WU, Naifeng , YAN, Xijun , ZHANG, Shunnan , YANG, Jianhui , ZHANG, Hongpo , DONG, Lina , LIU, Tong , SUN, Yan , ZHOU, Lihong , WANG, Hui , MA, Jie , YE, Zhengliang
IPC分类号： A61K36/804 , A61K36/74 , A61K36/71 , A61K36/66 , A61K36/536 , A61K36/486 , A61K36/482 , A61K36/236 , A61K36/232 , A61K35/56 , A61P25/04
CPC分类号： A61K36/65 , A61K35/618 , A61K36/232 , A61K36/236 , A61K36/48 , A61K36/505 , A61K36/804 , A61K2300/00
摘要： Chinese medicinal compositions for treating headache and formulations containing the same, and processes for preparation of said compositions and formulations containing the same. Chinese medicinal compositions of present invention are prepared from Angelicae sinensis, Ligusticum chuanxiong, Paeoniae alba, etc.
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6.发明公开MATRIX ADJUVANTS AND THE DROP PILLS PREPARED WITH THEM 有权MATRIX-ADJUVANTIEN UND DIE DEMIT HERGESTELLTEN TROPFEN UND PILLEN
公开(公告)号：EP1647269A1
公开(公告)日：2006-04-19
申请号：EP04738328.6
申请日：2004-07-02
发明人： CHEN, Jianming No. 1 Liaohedong Road , YAN, Xijun No. 1 Liaohedong Road Xinyibai Avenue , YANG, Yuewu No. 1 Liaohedong Road Xinyibai Avenue , LU, Wenliang No. 1 Liaohedong Road , ZHU, Yonghong No. 1 Liaohedong Road , YE, Zhengliang No. 1 Liaohedong Road , WANG, Wei No. 1 Liaohedong Road Xinyibai Avenue , ZHU, Guoguang No. 1 Liaohedong Road , ZHENG, Zhigang No. 1 Liaohedong Road , WANG, Shuangming No. 1 Liaohedong Road
摘要： The present invention relates to the matrix adjuvants for drop pills and the preparation of the drop pills. The matrix adjuvants for drop pills of the present invention comprise new matrix adjuvants with or without the plastifying components, which are typically natural matrix adjuvants derived from plants and of safety and non-toxicity. The present invention decreases the toxicity caused by polyethylene glycol, alters the situation that adjuvants derived from animals is scarce, improves the quality of drop pills and accelerates the development of drop pills.
摘要翻译： 本发明涉及滴丸的基质佐剂和滴丸的制备。 用于本发明的滴丸的基质助剂包含具有或不具有塑化组分的新的基质佐剂，其通常是衍生自植物的天然基质佐剂并且具有安全性和无毒性。 本发明降低了由聚乙二醇引起的毒性，改变了来自动物的佐剂稀少的情况，提高了滴丸的质量，加速了滴丸的发展。
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7.发明公开PREPARATION AND APPLICATION OF TRANSHINTOTALPHENOLIC ACID 有权VERFAHREN ZUR HERSTELLUNG VON GESAMT-SALVIANOLSÄURE
公开(公告)号：EP1506951A1
公开(公告)日：2005-02-16
申请号：EP03732181.7
申请日：2003-05-21
发明人： WEI, Feng , YUE, Hongshui , LI, Dekun , SUN, Jiangxiao , YE, Zhengliang , LI, Xu
IPC分类号： C07C59/52 , C07D307/84 , A61K31/19 , A61K31/34
CPC分类号： A61K31/34 , A61K31/19 , C07D307/84
摘要： A process for preparing tanshintotalphenolic acid and the use of the product are disclosed. The process comprises: tanshin is hot-extracted with water, the extract is separated and refined by polyamide column and macroporous adsorption resin column, and lyophilized to obtain tanshintotalphenolic acid. The yield of the final end product is more than 4 percent based on the amount of crude drug and the content of totalphenolic acid is more than 80 percent. The tanshintotalphenolic acid obtained can be used as the medicine for preventing and treating cerebrovascular and cardiovascular diseases and so on.
摘要翻译： 公开了制备丹参酚酸的方法及其用途。 该方法包括：将丹参用水热萃取，聚酰胺柱和大孔吸附树脂柱分离精制提取物，冻干得到丹参酚酸。 最终产品的产率基于生药量大于4％，总酚酸含量大于80％。 获得的丹参酚酸可用作预防和治疗脑血管和心血管疾病的药物等。
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8.发明公开
公开(公告)号：EP1351698A2
公开(公告)日：2003-10-15
申请号：EP01994322.4
申请日：2001-12-18
发明人： YAN, Xijun , WU, Naifeng , GUO, Zhixin , YE, Zhengliang , LIU, Yan
CPC分类号： A61K36/258 , A61K36/537 , A61K2300/00
摘要： This invention provides compositions comprising extracts of Radix Salviae Miltiorrhizae, Radix Notoginseng and Borneol. Said compositions comprise notoginsenoside R1 and ginsenoside Rg1 which are active components for therapeutic applications. This invention also provides a method of preparation of the said compositions and a method of identification and determination of the amount of individual effective components of said compositions. Finally, this invention provides various uses of the compositions.
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公开(公告)号：EP1506951B9
公开(公告)日：2009-08-26
申请号：EP03732181.7
申请日：2003-05-21
发明人： WEI, Feng , YUE, Hongshui , LI, Dekun , SUN, Jiangxiao , YE, Zhengliang , LI, Xu
IPC分类号： C07C59/52 , C07D307/84 , A61K31/19 , A61K31/34 , A61P9/00
CPC分类号： A61K31/34 , A61K31/19 , C07D307/84
摘要： A process for preparing tanshintotalphenolic acid and the use of the product are disclosed. The process comprises: tanshin is hot-extracted with water, the extract is separated and refined by polyamide column and macroporous adsorption resin column, and lyophilized to obtain tanshintotalphenolic acid. The yield of the final end product is more than 4 percent based on the amount of crude drug and the content of totalphenolic acid is more than 80 percent. The tanshintotalphenolic acid obtained can be used as the medicine for preventing and treating cerebrovascular and cardiovascular diseases and so on.
摘要翻译： 公开了制备丹参全草酚酸的方法和产品的用途。 该工艺包括：将丹参用水进行热萃取，萃取液经聚酰胺柱和大孔吸附树脂柱分离精制，冷冻干燥得到丹参全草酚酸。 基于生药量，最终成品的收率大于4％，总酚酸含量大于80％。 得到的丹参总酚酸可以作为预防和治疗脑血管疾病和心血管疾病的药物等。
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10.发明公开PHARMACEUTICAL COMPOSITION CONTAINING CHENOPODIUM AMBROSIOIDES EXTRACT AND ITS PREPARATION PROCESS AND APPLICATION 有权与EXTRACT土荆芥，你的过程及其应用的药物组合物
公开(公告)号：EP1982705A1
公开(公告)日：2008-10-22
申请号：EP06840721.2
申请日：2006-12-29
IPC分类号： A61K31/01 , A61K36/185 , A61K9/00 , A61P1/04
CPC分类号： A61K31/357 , A61K9/0095 , A61K9/1623 , A61K9/1652 , A61K9/2054 , A61K9/2059 , A61K9/2846 , A61K9/2866 , A61K9/4866 , A61K31/01 , A61K31/015 , A61K36/185 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/24 , A61K47/26 , A61K47/44
摘要： The present invention relates to plant extracts, specifically, the extracts of Chinese medicine Chenopodium ambrosioides L. and the composition comprising thereof. The extracts of Chinese medicine Chenopodium ambrosioides L. are prepared by conventional methods for the extraction of volatile oil, and can be used to treat Helicobacter Pylori-induced diseases of digestive system, such as gastritis, gastric ulcer, etc., with easy availability of raw materials, simple preparations, prominent effects, and less side-effect.
摘要翻译： 本发明涉及植物提取物，具体而言，中国医药藜的提取物荆芥L.和其包含所述组合物。 中国医药土荆芥L的提取物通过挥发油的提取的常规方法制备，并且可用于治疗消化系统，颜色的幽门螺杆菌诱发的疾病：如胃炎，胃溃疡等，具有容易获得 原料，简单的制剂，突出效果，较少副作用。
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