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公开(公告)号：EP3274340A1
公开(公告)日：2018-01-31
申请号：EP16717211.3
申请日：2016-03-23
IPC分类号： C07D307/84 , A61K31/343 , A61P31/14
CPC分类号： C07D307/84 , A61K31/343 , A61K45/06
摘要： The present invention provides, among other things, compounds represented by the general Formula I: (I) and pharmaceutically acceptable salts thereof, wherein L and A (and further substituents) are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.
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2.发明授权COMPOSITIONS INCLUDING 6-AMINOHEXANOIC ACID DERIVATIVES AS HDAC INHIBITORS 有权ZUSAMMENSETZUNGEN MIT 6-AMINOHEXANSAUREDERIVATEN ALS HDAC-HEMMER
公开(公告)号：EP2330894B8
公开(公告)日：2017-04-19
申请号：EP09812248.4
申请日：2009-09-03
IPC分类号： C07C235/16 , C07C237/22 , C07C255/57 , C07C311/16 , C07C311/19 , C07C317/44 , C07C323/62 , C07D209/48 , C07D213/30 , C07D231/56 , C07D277/56 , C07D295/14 , C07D307/84 , C07D409/12 , A01N37/18 , A61K31/00 , A61K31/16
CPC分类号： C07C233/80 , A61K31/00 , A61K31/16 , C07C235/16 , C07C237/22 , C07C255/57 , C07C311/16 , C07C311/19 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2601/14 , C07D209/48 , C07D213/30 , C07D213/81 , C07D217/24 , C07D231/12 , C07D231/56 , C07D237/24 , C07D241/24 , C07D241/44 , C07D271/12 , C07D277/56 , C07D295/14 , C07D295/15 , C07D307/84 , C07D307/85 , C07D333/38 , C07D409/12 , Y02A50/411
摘要： This invention relates to compounds of Formula (I) wherein Cy1, L1, Y, R1, L2, and Ar2 are defined herein, for the treatment of cancers, inflammatory disorders, and neurological conditions.
摘要翻译： 本发明涉及式（I）化合物，其中Cy1，L1，Y，R1，L2和Ar2在本文中定义，用于治疗癌症，炎症性疾病和神经病症。
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公开(公告)号：EP2995611A4
公开(公告)日：2016-10-12
申请号：EP14794817
申请日：2014-05-07
IPC分类号： C07C237/22 , A61K31/166 , A61K31/343 , A61K31/36 , A61K31/381 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/435 , A61K31/437 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/455 , A61K31/47 , A61K31/472
CPC分类号： C07C233/81 , C07C237/22 , C07C237/36 , C07C255/60 , C07C271/22 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D213/56 , C07D213/81 , C07D213/82 , C07D213/84 , C07D215/54 , C07D217/26 , C07D221/04 , C07D231/14 , C07D233/90 , C07D237/08 , C07D237/24 , C07D239/26 , C07D239/28 , C07D241/12 , C07D241/24 , C07D261/18 , C07D263/34 , C07D271/08 , C07D275/02 , C07D277/20 , C07D277/30 , C07D277/56 , C07D307/78 , C07D307/82 , C07D307/84 , C07D317/62 , C07D333/38 , C07D333/70 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D487/04
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公开(公告)号：EP1765803B1
公开(公告)日：2016-03-09
申请号：EP05766641.4
申请日：2005-06-22
发明人： LAGU, Bharat , WACHTER, Michael, P.
IPC分类号： C07D309/14 , C07D309/04 , C07D307/14 , C07D333/36 , C07D335/02 , C07D295/12 , C07D309/32 , C07D407/12 , C07D409/12 , C07D405/12 , C07D307/56 , C07D307/84 , C07D313/08 , A61K31/341 , A61K31/351
CPC分类号： C07D209/42 , C07C233/80 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D235/24 , C07D295/135 , C07D307/14 , C07D307/22 , C07D307/52 , C07D307/56 , C07D307/84 , C07D309/04 , C07D309/14 , C07D311/58 , C07D311/92 , C07D313/08 , C07D333/36 , C07D333/70 , C07D335/02 , C07D405/12 , C07D407/12 , C07D409/12
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公开(公告)号：EP2688879A1
公开(公告)日：2014-01-29
申请号：EP12717365.6
申请日：2012-03-23
申请人： SANOFI
IPC分类号： C07D307/80 , C07D307/84
CPC分类号： C07D307/80 , C07C311/08 , C07C311/21 , C07D307/83 , C07D307/84
摘要： The invention relates to a process for synthesizing benzofuran derivatives, in particular dronedarone of formula (D), comprising a step of Friedel-Crafts acylation starting from a sulfonamido-benzofuran ester intermediate.
摘要翻译： 合成苯并呋喃衍生物的方法本发明涉及合成苯并呋喃衍生物，特别是式（D）决奈达隆的方法，其包括从磺酰氨基苯并呋喃酯中间体开始的Friedel-Crafts酰化步骤。
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公开(公告)号：EP2045014B1
公开(公告)日：2014-01-15
申请号：EP07767218.6
申请日：2007-06-20
IPC分类号： B01J31/22 , C07C67/317 , C07C69/753 , C07C69/757 , C08F8/42 , C08F212/00 , C07B53/00 , C07B61/00 , C07D307/84 , B01J31/16
CPC分类号： C07C67/317 , B01J31/1658 , B01J31/2239 , B01J31/2243 , B01J31/226 , B01J2231/321 , B01J2231/323 , B01J2231/325 , B01J2231/326 , B01J2231/327 , B01J2231/342 , B01J2231/348 , B01J2231/46 , B01J2231/645 , B01J2531/0219 , B01J2531/822 , C07B53/00 , C07D209/48 , C07D307/84 , C08F8/42 , C08F212/08 , C07C69/753 , C07C69/757 , C08F212/00 , C08F212/32 , C08F212/34
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公开(公告)号：EP2588464A1
公开(公告)日：2013-05-08
申请号：EP11730159.8
申请日：2011-06-28
发明人： YEUNG, Kap-Sun , BENO, Brett R. , KADOW, John F.
IPC分类号： C07D307/84 , C07D405/12 , A61K31/343 , A61K31/51 , A61P31/00
CPC分类号： C07D307/84 , A61K31/343 , A61K31/51 , C07D405/12
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity agamst hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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公开(公告)号：EP2448934A4
公开(公告)日：2012-12-05
申请号：EP10794458
申请日：2010-06-29
申请人： ASTRAZENECA AB
发明人： ANDERSSON JOHAN , GYBAECK HELENA , JOHANSSON ANH , LINDE CHRISTIAN ERIK , MALMSTROEM JONAS , NORDVALL GUNNAR , TERP GITTE , WEIGELT TATJANA
IPC分类号： C07D405/14 , A61K31/443 , A61K31/444 , A61P25/00 , C07D307/82 , C07D307/84 , C07D405/12 , C07D417/14
CPC分类号： C07D405/12 , C07D307/84 , C07D307/85 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/14
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公开(公告)号：EP2382189A1
公开(公告)日：2011-11-02
申请号：EP09804188.2
申请日：2009-12-30
发明人： ALONSO, Jorge , ENCINAS LOPEZ, Arantxa , MUELBAIER, Marcel , AMMENN, Jochen , WENDT, Bernd , LEWIS, Joe , SCHULTES, Christoph , JANSSEN, Bernd
IPC分类号： C07C311/21 , C07D213/76 , C07D231/42 , C07D249/14 , C07D257/04 , C07D261/16 , C07D277/52 , C07D307/66 , C07D333/36 , C07D207/416 , A61P35/00 , A61K31/18 , A61K31/41 , A61K31/341 , A61K31/381
CPC分类号： C07C311/21 , C07C311/29 , C07C311/39 , C07D207/335 , C07D207/34 , C07D213/42 , C07D213/61 , C07D213/63 , C07D213/64 , C07D213/74 , C07D213/84 , C07D213/85 , C07D231/12 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/32 , C07D277/28 , C07D307/52 , C07D307/84 , C07D333/20 , C07D333/38
摘要： The present invention provides novel compounds that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor (HIF)-mediated transcription and signaling under hypoxic conditions. In one aspect, the compounds of the present invention are useful for the preparation of a medicament for the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularisation. Also provided is a pharmaceutical composition comprising a compound of the invention and a second therapeutic agent or radiation useful for the treatment or prevention of the mentioned diseases or disorders. In a first aspect the present invention relates to a compound having a structure according to formula (I).
摘要翻译： 本发明提供抑制细胞增殖和细胞分裂并抑制低氧条件下缺氧诱导因子（HIF）介导的转录和信号传导的活化的新化合物。 一方面，本发明化合物可用于制备用于治疗或预防选自以下的疾病或病症的药物：炎性疾病，过度增殖性疾病或病症，缺氧相关病变和 以过度血管化为特征的疾病。 还提供了包含本发明化合物和用于治疗或预防所述疾病或病症的第二治疗剂或辐射的药物组合物。 在第一方面，本发明涉及具有根据式（I）的结构的化合物。
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公开(公告)号：EP1935882B1
公开(公告)日：2011-02-09
申请号：EP08005358.0
申请日：2002-10-25
发明人： Miyoshi, Shiro , Ogawa, Kohei
IPC分类号： C07D209/12 , C07D209/42 , C07D209/14 , C07D209/18 , C07D307/84 , C07D307/79 , C07D405/06 , C07D413/06 , C07D401/04 , C07D231/56 , A61K31/343 , A61K31/404 , A61K31/4045 , A61K31/4439 , A61K31/454 , A61P1/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P13/02 , A61P25/24 , A61P43/00
CPC分类号： C07D413/06 , A61K31/343 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/422 , A61K31/4439 , A61K31/454 , C07D209/04 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/22 , C07D209/32 , C07D209/42 , C07D231/56 , C07D307/79 , C07D307/83 , C07D307/84 , C07D307/85 , C07D333/64 , C07D401/04 , C07D405/06
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