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公开(公告)号：EP3690442B1
公开(公告)日：2021-09-22
申请号：EP20151803.2
申请日：2013-09-30
发明人： RAJASEKARAN, John, J. , JAYARAMAN, Vasanth , WANG, Tianhao , BEI, Kang , KRISHNAMURTHY, Hari, Krishnan
IPC分类号： G01N33/543
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公开(公告)号：EP3702782A3
公开(公告)日：2020-11-11
申请号：EP20153448.4
申请日：2014-02-17
发明人： RAJASEKARAN, John J , JAYARAMAN, Vasanth , WANG, Tianhao , BEI, Kang , KRISHNAMURTHY, Hari Krishnan
IPC分类号： G01N33/543
摘要： Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
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公开(公告)号：EP3107926B1
公开(公告)日：2020-09-09
申请号：EP15751793.9
申请日：2015-02-23
发明人： JAYARAMAN, Vasanth
IPC分类号： C07K1/04 , C07K1/10 , C07D257/04
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公开(公告)号：EP3368909A1
公开(公告)日：2018-09-05
申请号：EP16860594.7
申请日：2016-10-25
发明人： RAJASEKARAN, John, J. , JAYARAMAN, Vasanth , WANG, Tianhao , BEI, Kang , KRISHNAMURTHY, Hari, Krishnan , KRISHNA, Karthik
CPC分类号： G01N1/28 , G01N35/0099 , G01N35/028
摘要： Disclosed herein are methods, tools, pillar plates, and tool assemblies for biomolecular analysis using microarrays that reduces the likelihood of air bubbles being trapped by the microarrays. Embodiments of the tools include two clamps that have a tool mount portion and a grasping portion. The tool mount portion is configured to engage a lifting mechanism of a plate handling robot for moving a pillar plate that include microarrays. The grasping portion is configured to freely suspend the pillar plate at an inclination of a non-zero tilt angle relative to a plane normal to the tool mount portion. Embodiments of pillar plates include two protruding edges on opposite sides of the pillar plate and a plurality of pillars with one or more affixed microarrays. Embodiments of the tool assembly include the tool and the pillar plate, wherein the protruding edges are configured to engage with the grasping portions.
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公开(公告)号：EP3191629A4
公开(公告)日：2018-07-11
申请号：EP15839169
申请日：2015-09-10
申请人： VIBRANT HOLDINGS LLC
发明人： RAJASEKARAN JOHN J , JAYARAMAN VASANTH , BEI KANG , WANG TIANHAO , KRISHNA KARTHIK , KRISHNAMURTHY HARI KRISHNAN
CPC分类号： G01N33/564 , A61K38/10 , A61K39/00 , C07K7/08 , C40B40/10 , G01N33/6854 , G01N33/6878 , G01N2800/02 , G01N2800/24
摘要： The present disclosure relates generally to biomarkers and peptide arrays, and, more particularly, to a method of using a peptide array to identify biomarkers for an autoimmune disease such as, e.g., celiac disease. Furthermore, a set of novel biomarkers for celiac disease, having high sensitivity and specificity, are disclosed in addition to method of treatment using the novel biomarkers.
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公开(公告)号：EP3268740A1
公开(公告)日：2018-01-17
申请号：EP16762696.9
申请日：2016-03-14
发明人： RAJASEKARAN, John, J. , WANG, Tianhao , BEI, Kang , JAYARAMAN, Vasanth , KRISHNAMURTHY, Hari, Krishnan
IPC分类号： G01N33/53
CPC分类号： G01N33/54353 , B01J19/0046 , B01J2219/00432 , B01J2219/00509 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00711 , B01J2219/00725
摘要： Disclosed herein are formulations, substrates, and arrays. In certain embodiments, methods of attaching a biomolecule to an array using a photoactivated conjugation compound are disclosed. Methods of generating site-specific attachment of biomolecules to an array are also disclosed. Arrays generated by these methods and methods of using these arrays are also disclosed.
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公开(公告)号：EP2812344A4
公开(公告)日：2015-10-28
申请号：EP13747275
申请日：2013-02-07
申请人： VIBRANT HOLDINGS LLC
IPC分类号： C09K11/64 , C07C211/62 , G01N33/543 , G01N33/68
CPC分类号： B01J19/0046 , B01J2219/00432 , B01J2219/00596 , B01J2219/00621 , B01J2219/00639 , B01J2219/00659 , B01J2219/00711 , B01J2219/00725 , C07K1/047 , C40B40/10 , G01N33/54353 , G01N2800/00
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8.发明公开METHODS, SYSTEMS, AND ARRAYS FOR BIOMOLECULAR ANALYSIS 审中-公开VERFAHREN，SYSTEME UND ANORDNUNGENFÜRBIOMOLEKULARE ANALYZE
公开(公告)号：EP2901159A2
公开(公告)日：2015-08-05
申请号：EP13783134.3
申请日：2013-09-30
发明人： RAJASEKARAN, John, J. , JAYARAMAN, Vasanth , WANG, Tianhao , BEI, Kang , KRISHNAMURTHY, Hari, Krishnan
IPC分类号： G01N33/543
摘要： Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
摘要翻译： 本文公开了制剂，底物和阵列。 本文还公开了制备和使用制剂，基底和阵列的方法。 还公开了用于鉴定可用于诊断和治疗病症的肽序列的方法，以及使用肽序列诊断和治疗疾病例如乳糜泻的方法。 在某些实施方案中，底物和阵列包括用于合成和附着聚合物或生物分子的多孔层。
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公开(公告)号：EP2901159B1
公开(公告)日：2020-02-26
申请号：EP13783134.3
申请日：2013-09-30
发明人： RAJASEKARAN, John, J. , JAYARAMAN, Vasanth , WANG, Tianhao , BEI, Kang , KRISHNAMURTHY, Hari, Krishnan
IPC分类号： G01N33/543 , C40B30/04 , C40B40/10
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公开(公告)号：EP2920272B1
公开(公告)日：2019-08-21
申请号：EP13798499.3
申请日：2013-11-14
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