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58 条记录 (耗时 0.031 秒)

    Imaging Volumes with Arbitrary Geometries in Contact and Non-Contact Tomography
    3.
    发明公开
    Imaging Volumes with Arbitrary Geometries in Contact and Non-Contact Tomography 审中-公开
    在接触和非接触断层任意几何成像介质

    公开(公告)号：EP2410315A3

    公开(公告)日：2014-07-30

    申请号：EP11182730.9

    申请日：2003-06-04

    申请人： VisEn Medical, Inc.

    发明人： Ripoll, Jorge ,  Ntziachristos, Vasilis ,  Madden, Karen N

    IPC分类号： G01N21/47 ,  A61B5/00

    摘要： A method for tomographic imaging of diffuse medium includes directing waves into a diffusive medium, solving a surface-bounded inversion problem by forward field calculations calculations through decomposition of contributions from the multiple reflections from an arbitrary surface within the diffusive medium or outside the diffusive medium into a sum of different orders of reflection up to an arbitrary order, and using contact or non-contact measurements of waves outside said diffusive medium to generate a tomographic image.

    Fluorescent imaging agents
    4.
    发明公开
    Fluorescent imaging agents 有权
    Fluoreszierende Bildgebungsmittel

    公开(公告)号：EP2732826A1

    公开(公告)日：2014-05-21

    申请号：EP13185417.6

    申请日：2009-01-17

    申请人： VisEn Medical, Inc.

    发明人： Rajopadhye, Milind ,  Groves, Kevin ,  Preda, Dorin V

    IPC分类号： A61K49/00 ,  A61K49/04 ,  A61K47/48

    CPC分类号： A61K49/0032 ,  A61K47/65 ,  A61K49/0056 ,  C07K5/1019 ,  C07K7/06 ,  C07K7/64 ,  C09B23/0008 ,  C09B23/083 ,  C09B23/086

    摘要： Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.

    摘要翻译： 提供了用于体内和体外成像的分子内骤冷显像剂家族，其包含至少一个可酶促切割的寡肽和两个荧光团或荧光团和猝灭剂。 当进行蛋白水解切割时，至少一个荧光团是未淬灭的，并且在用适当波长的光激发时能够产生荧光信号。 还提供了使用这种成像剂的体内和体外成像方法。

    SYSTEMS AND METHODS FOR VIRTUAL INDEX-MATCHING OF DIFFUSIVE MEDIA
    5.
    发明公开
    SYSTEMS AND METHODS FOR VIRTUAL INDEX-MATCHING OF DIFFUSIVE MEDIA 有权
    系统和虚拟索引平衡扩散器MEDIA方法

    公开(公告)号：EP2480126A1

    公开(公告)日：2012-08-01

    申请号：EP10776206.4

    申请日：2010-09-22

    申请人： Visen Medical, Inc.

    发明人： RIPOLL, Lorenzo, Jorge ,  YARED, Wael, I. ,  KEMPNER, Joshua

    IPC分类号： A61B5/00 ,  G01N21/47 ,  G06T11/00

    CPC分类号： A61B5/0073 ,  A61B6/037 ,  A61B2562/146 ,  G01N21/6456 ,  G01N21/6486 ,  G01N2021/1787

    摘要： The invention relates to systems and methods for tomographic imaging of a subject comprising diffuse media by converting measurements of electromagnetic radiation, e.g., fluorescent light, obtained in free space exterior to the subject into data that would be measured if the subject were surrounded by an infinite and homogeneous diffusive medium, e.g., a medium with optical properties equal to the average optical properties of the subject. After applying a transformation to convert measurements to virtually-matched values, propagation of light is simulated from the index-matched surface to a set of virtual detectors exterior to the subject and arranged in a geometrically advantageous fashion, for example, in a planar array, thereby facilitating the use of fast reconstruction techniques.

    ANIMAL HOLDER FOR IN VIVO TOMOGRAPHIC IMAGING WITH MULTIPLE MODALITIES
    6.
    发明公开
    ANIMAL HOLDER FOR IN VIVO TOMOGRAPHIC IMAGING WITH MULTIPLE MODALITIES 有权
    动物HOLDER层析成像与多个方法和程序体内成像

    公开(公告)号：EP2265181A1

    公开(公告)日：2010-12-29

    申请号：EP09724324.0

    申请日：2009-03-25

    申请人： Visen Medical, Inc.

    发明人： YARED, Wael, I. ,  WILSON, Andrew, K.

    IPC分类号： A61B6/04 ,  A61D3/00

    CPC分类号： A61B6/045 ,  A61B5/7285 ,  A61B6/0421 ,  A61B6/485 ,  A61B6/508 ,  A61B6/583 ,  A61B8/543 ,  A61B2503/40

    摘要： The invention facilitates transport of an immobilized, anesthetized small animal across multiple single-modality or multiple-modality imaging workstations at the same or different physical locations without loss of subject positional information. The animal holder is compatible with preclinical animal imaging stations such as micro-CT, micro-MR, micro-PET, micro-SPECT, and FMT. The animal holder is configured to be accommodated by (for example, fit within) individual imaging chambers of such instruments and is fabricated from materials that are compliant with all of the imaging modalities used. In certain embodiments, an integrated set of fiducial marker wells accommodates the dispensing of markers that are picked up by several modalities simultaneously in multiple planes. The fiducial markers then are aligned in standard image processing or image analysis software with simple image translation and rotation operations, without the need for more advanced scaling, distortion or other operations. The animal holder optionally also includes a system for providing the animal with inhalation anesthesia, for example, isoflurane, and is designed to fit into identical receptacles inside or outside the imaging workstation(s) that provide heating to minimize or prevent animal hypothermia.

    New fluorescence cyanine labels containing a sulfamido linker arm
    8.
    发明公开
    New fluorescence cyanine labels containing a sulfamido linker arm 有权
    含有磺酰氨基连接臂的新型荧光花菁标记

    公开(公告)号：EP1491591A1

    公开(公告)日：2004-12-29

    申请号：EP04023147.4

    申请日：1999-07-02

    申请人： Visen Medical, Inc.

    发明人： Caputo, Giuseppe ,  Della Ciana, Leopoldo

    IPC分类号： C09B23/02 ,  C07H21/00 ,  C07H19/04 ,  C12Q1/68 ,  G01N33/58

    CPC分类号： C07H21/00 ,  C07H19/04 ,  C09B23/02 ,  G01N33/533 ,  G01N33/582

    摘要： A fluorescent cyanine dye of the following general formula is disclosed:
    wherein:

    X 1 and X 2 are indipendently selected from the group consisting of -O-, -S-, -C(CH 3 ) 2 or -C=CH 2 ;
    Y 1 and Y 2 are nonmetal atoms required to form a benzo-condensed or naphtho-condensed ring; Q is a conjugated moiety that increases the fluorescent quantum yield and the stability of the compound;
    R 1 and R 2 are indipendently selected from the group consisting of H, C 1 -C 4 , alkyl, alkylensulfonic group or alkylensulfonate group wherein the alkylene group has from 1 to 4 carbon atoms; R3, R4 and R5 are indipendently selected from the group consisting of H, a sulfonic group, a sulfonate group, alkylensulfonic, alkylensulfonate and -SO 2 NH(CH 2 ) m -W-(CH 2 ) n Z, wherein alkylene has 1 to 4 carbon atoms, with the proviso that at least one of R 1 to R 5 contains a sulfonic or sulfonate group; W is absent or is a group selected from -SO 2 NH, -O-, -COO-, or -CONH-; n = 0-12 and m = 0-12 with the provisoes that m+n ≤ 12 and at least one of m and n ≠ 0; and Z is, or contains a N, O or S nucleophile functionality or is, or contains a functionality capable of reacting with N, O or S nucleophiles. Nucleophile functionalities include -NH 2 , -OH, and -SH groups; groups capable of reacting with such functionalities include -COCl, -COOCOR, -CONHNH 2 , N-hydroxysuccinimido esters, -NCS, -CHO, -COCH 2 I, phosphoramidite and maleimido.

    摘要翻译： 公开了以下通式的荧光花青染料：其中：X 1和X 2独立地选自-O - ， - S - ， - C（CH 3）2或-C = CH 2; Y1和Y2是形成苯并稠合或萘缩合环所需的非金属原子; Q是增加荧光量子产率和化合物稳定性的缀合部分; R 1和R 2独立地选自H，C 1 -C 4，烷基，亚烷基磺酸基或亚烷基磺酸酯基，其中亚烷基具有1至4个碳原子; R 3，R 4和R 5独立地选自H，磺酸基，磺酸酯基，亚烷基磺酸，亚烷基磺酸酯和-SO 2 NH（CH 2）m W-（CH 2）n Z，其中亚烷基具有1至4个碳原子， 条件是R 1至R 5中的至少一个含有磺酸基或磺酸基; W不存在或者是选自-SO2NH，-O - ， - COO-或-CONH-的基团; n = 0-12和m = 0-12，其中条件是m +n≤12且m和n中的至少一个不为0; Z是或含有N，O或S亲核官能团或者是或含有能够与N，O或S亲核试剂反应的官能团。 亲核体官能团包括-NH 2，-OH和-SH基团; 能够与这些官能团反应的基团包括-COCl，-COOCOR，-CONHNH2，N-羟基琥珀酰亚胺酯，-NCS，-CHO，-COCH2I，亚磷酰胺和马来酰亚胺基。