公开(公告)号：EP2732826A1

公开(公告)日：2014-05-21

申请号：EP13185417.6

申请日：2009-01-17

申请人： VisEn Medical, Inc.

发明人： Rajopadhye, Milind ,  Groves, Kevin ,  Preda, Dorin V

IPC分类号： A61K49/00 ,  A61K49/04 ,  A61K47/48

CPC分类号： A61K49/0032 ,  A61K47/65 ,  A61K49/0056 ,  C07K5/1019 ,  C07K7/06 ,  C07K7/64 ,  C09B23/0008 ,  C09B23/083 ,  C09B23/086

摘要： Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.

摘要翻译： 提供了用于体内和体外成像的分子内骤冷显像剂家族，其包含至少一个可酶促切割的寡肽和两个荧光团或荧光团和猝灭剂。 当进行蛋白水解切割时，至少一个荧光团是未淬灭的，并且在用适当波长的光激发时能够产生荧光信号。 还提供了使用这种成像剂的体内和体外成像方法。

公开(公告)号：EP2732826B1

公开(公告)日：2017-11-08

申请号：EP13185417.6

申请日：2009-01-17

申请人： VisEn Medical, Inc.

发明人： Rajopadhye, Milind ,  Groves, Kevin ,  Preda, Dorin V

IPC分类号： A61K49/00 ,  A61K49/04

CPC分类号： A61K49/0032 ,  A61K47/65 ,  A61K49/0056 ,  C07K5/1019 ,  C07K7/06 ,  C07K7/64 ,  C09B23/0008 ,  C09B23/083 ,  C09B23/086

摘要： Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.