公开(公告)号：EP0779076B1

公开(公告)日：2005-03-09

申请号：EP95924554.9

申请日：1995-06-27

申请人： Immunotech Developments Inc.

发明人： DEIGIN, Vladislav Isakovich ,  YAROVA, Elena Petrovna

IPC分类号： C07K5/10 ,  A61K38/00 ,  C07K7/06

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K5/1016 ,  C07K5/1019 ,  Y02P20/55

摘要： The invention is a peptide of general formula (I) X-Tyr-Y-Phe-Z-A, wherein: X represents H or Arg, D-Arg, Orn, D-Orn, Lys, D-Lys, Har, D-Har, Cyt, D-Cyt; Y represents D-Ala, D-Val, D-Leu, D-Ile, D-Phe, D-Asn, D-Trp, D-Pro, D-Ser, D-Thr, D-Tyr, D-Hyp, D-Cys, D-Cys-Cys, D-Met, D-Lys, D-Har, D-Arg, D-His, D-Asp, D-Glu, D- beta -Ala, D-Orn; Z represents Ala, D-Ala, Val, D-Val, Leu, D-Leu, Ile, D-Ile, Phe, D-Phe, Asn, D-Asn, Gly, Gln, D-Gln, Trp, D-Trp, Pro, D-Pro, Ser, D-Ser, Thr, D-Thr, Tyr, D-Tyr, Hyp, D-Hyp, Cys, D-Cys, Cys-Cys, Cys-D-Cys, D-Cys-Cys, D-Cys-D-Cys, Met, D-Met, Lys, D-Lys, Arg, D-Arg, His, D-His, Asp, D-Asp, Glu, D-Glu, beta -Ala, D- beta -Ala, Orn, D-Orn; and A represents OH or a substituted amide (C1-C3). According to the invention, the proposed peptide of general formula (I) is obtained by the gradual construction of a peptide chain, starting from C-terminated amino acid Z, in the form of a substituted amide or carboxyl-protected group, by addition using the method of activated ethers or mixed anhydrides of a successive N-protected amino acid; the N-protective group is split off and the successive N-protected amino acid is re-added to produce a tetra- or pentapeptide which is unblocked in the presence of a palladium catalyst, and the target product is separated out. The proposed peptide and a compound based on it can be used as an agent with pronounced opiate-like properties and also has anabolic properties which increase body weight as well as promoting activity in the growing zones and development of the epidermal layer including the hair. The bio-stimulating properties of the claimed peptide are also evident in the healing of wounds and repair processes.

公开(公告)号：EP0868198B1

公开(公告)日：2004-03-10

申请号：EP96940708.9

申请日：1996-12-18

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

发明人： FISHMAN, Ala Medical School of Hadasa ,  YARKONI, Shai Medical School of Hadasa ,  LORBERBOUM-GALSKI, Haya Medical School of Hadasa

IPC分类号： A61K47/48

CPC分类号： C07K19/00 ,  A61K38/00 ,  A61K47/68 ,  A61K47/6829 ,  C07K2319/00

摘要： The present invention generally relates to a new approach for thetherapy of allergic responses, based on targeted elimination of cells expressing the Fc epsilon RI receptor by a chimeric cytotoxin Fc2'-3-PE40. A sequence encoding amino acids 301-437 of the Fc region of the mouse IgE molecule was genetically fused to PE40 - a truncated form of PE lacking the cell binding domain. The chimeric protein, produced in E. coli, specifically and efficiently kills mouse mast cell lines expressing the Fc epsilon RI receptor, as well as primary mast cells derived from bone marrow. The present invention provides a chimeric protein for targeted elimination of Fc epsilon RI expressing cells especially useful for the therapy of allergic responses. The said chimeric protein is comprised of a cell targeting moiety for Fc epsilon RI expressing cells and a cell killing moiety. The preferred killing moiety is the bacterial toxin Pseudomonas exotoxin (PE). This Pseudomonas exotoxin is a product of Pseudomonas aeruginosa. The present invention also relates to a method for the preparation of said protein. This chimeric protein is prepared by genetically fusing the Fc region of the mouse IgE molecule to PE40, a truncated form of PE lacking the cell binding domain. The present invention also provides pharmaceutical compositions, for the treatment of allergic diseases and for the treatment of hyperplasias and malignancies, comprising as an active ingredient the above mentioned chimeric protein and a conventional adjuvant product.

公开(公告)号：EP1241479A3

公开(公告)日：2004-01-14

申请号：EP01106463.1

申请日：2001-03-23

申请人： Immundiagnostik AG ,  ABC Armbruster Biochemicals

发明人： Armbruster, Franz Paul ,  Stangl, Karl, Humboldt-Universität ,  Dschietzig, Thomas, Humboldt-Universität ,  Voelter, Wolfgang ,  Heller, Jörg

IPC分类号： G01N33/74 ,  G01N33/543 ,  C07K14/575 ,  G01N33/53

CPC分类号： G01N33/74 ,  G01N33/6893 ,  G01N2333/5751 ,  G01N2800/32

摘要： Method of determining the biological active urotensin II in a sample of a body fluid, comprising contacting the sample with polyclonal and/or monoclonal antibodies which have been elicted by immunisation with a cyclic peptide having the sequence: having a disulfide bridge formed between Cys 5 and Cys 10, and comprising the artificial sequence βAla-Cys, optionally conjugated with a carrier peptide. The obtained antibodies are then either purified or characterised by their binding to cyclic human urotensin II and can be used in a binding assay for a diagnosis of cardiovascular diseases, heptarenal syndrome, cirrhosis, diseases involving haemodynamic alterations, pathological conditions involving vasocontrictive substances.

公开(公告)号：EP1300259A2

公开(公告)日：2003-04-09

申请号：EP02018169.9

申请日：2002-08-19

申请人： Chao, Chung-Ping

发明人： Chao, Chung-Ping

IPC分类号： B43K7/00

CPC分类号： B43K1/082 ,  B43K7/10

摘要： A ballpoint (10) pen has an ink reservoir tube (12) which stores ink (13), a point assembly (14) disposed in the front of the ink reservoir tube (12), and a ball bearing (16) held at the front end of the point assembly (14). The ball bearing (16) is a shape memory alloy (SMA), Preferably a TiNi intermetallic compound or a TiNi based alloy. The ball bearing (16) solves the problem of ink failing to flow when the ballpoint pen (10) is dropped on the ground.

摘要翻译： 圆珠笔（10）笔具有储存油墨（13）的储墨器管（12），设置在储墨器管（12）前面的点组件（14）和保持在储墨器 点组件（14）的前端。 球轴承（16）是形状记忆合金（SMA），优选为TiNi金属间化合物或TiNi基合金。 滚珠轴承（16）解决了当圆珠笔（10）落在地面上时油墨不能流动的问题。

公开(公告)号：EP1298688A1

公开(公告)日：2003-04-02

申请号：EP01118753.1

申请日：2001-08-07

申请人： Silitek Corporation

发明人： Goh, Keanyeong

IPC分类号： H01H13/70

CPC分类号： H01H13/70 ,  H01H9/18 ,  H01H2219/028 ,  H01H2229/006

摘要： The present invention relates to an apparatus for keyboard pad-printing and a method thereof for printing on the contact surfaces of keys of a keyboard in order to form a protective film layer with clamped-pattern peaks and valleys on each of the keys of the keyboard. The apparatus comprises a clamped-pattern printing board and a pad-printing module. The clamped-pattern printing board has a roughened surface on which clamped-pattern peaks and valleys are provided, and the pad-printing module has a plurality of pads. The invention forms a protective film layer on the contact surface by pressing the pad-printing module onto the roughened surface with the protective coating thereon, and then pressing the pads onto the contact surfaces, so that the protective film layer protects the symbol pattern on the key, and the cost and flaw rate of the keyboard pad-print are both reduced, thus simplifying the manufacturing process.

摘要翻译： 本发明涉及一种用于键盘打印的设备及其方法，用于在键盘的键的接触面上进行打印，以形成在键盘的每个键上具有夹紧图案峰和谷的保护膜层 。 该装置包括夹紧图案印刷板和垫印刷模块。 夹持图案印刷板具有粗糙表面，在其上提供夹紧图案的峰和谷，并且印刷模块具有多个垫。 本发明在接触表面上形成保护膜层，通过在其上具有保护涂层的方式将垫印刷模块压在粗糙表面上，然后将垫压在接触表面上，使得保护膜层保护在 键盘，并且键盘打印的成本和缺陷率都降低了，从而简化了制造过程。

公开(公告)号：EP1257823A2

公开(公告)日：2002-11-20

申请号：EP01919280.6

申请日：2001-02-14

申请人： Immundiagnostik AG ,  Ganzimmun Ag

发明人： ARMBRUSTER, Franz, Paul,Immundiagnostik AG ,  CREVAR, Katarina ,  RUPPERT, Jana

IPC分类号： G01N33/569

CPC分类号： G01N33/56922 ,  G01N33/54306 ,  G01N33/56911 ,  G01N33/6854

摘要： The invention relates to a method for detecting pathogenic organisms, especially Helicobacter pylori and H. heilmanii, in fecal, salivary and secretion specimen by a double antibody sandwich assay. The inventive method is characterized by dissolving or dispersing the specimen together with a pathogenic antigen in a buffer solution and contacting the buffer solution with a solid phase to which at least two primary antibodies are bound, one of which specifically binds to the pathogenic antigen and the other to human immunoglobulin A; washing the solid phase of non-specifically bound proteins and contacting the solid phase with a secondary antibody that specifically binds to the pathogenic antigen; and determining the amount of specifically bound secondary antibody.

公开(公告)号：EP0804477B1

公开(公告)日：2002-10-23

申请号：EP95917331.1

申请日：1995-04-18

申请人： STATE OF ISRAEL-MINISTRY OF AGRICULTURE ,  Benedum, Ulrich Max

发明人： ALTSTEIN, Miriam

IPC分类号： C07K14/435 ,  A01N63/02

CPC分类号： A01N63/02 ,  C07K14/43563 ,  Y10S530/858

摘要： Synthetic peptide fragments from pheromone biosynthesis activating neuropeptide PBAN (1-33)-NH2 of Helicoverpa zea which have either pheromone biosynthesis stimulating or inhibiting activity.

公开(公告)号：EP0905912A3

公开(公告)日：2002-07-10

申请号：EP98117509.4

申请日：1998-09-22

申请人： Circuit Design Inc.

发明人： Koike, Yukinaga

IPC分类号： H04B1/04 ,  H03C3/09 ,  H04L27/12

CPC分类号： H04B1/034

摘要： A wireless microphone use UHF band carrier FM transmitter adopting a PLL system, which has a voltage controlled crystal oscillation type modulator (VCXO) for performing FM modulation on an oscillation frequency of a crystal oscillation circuit by an input of a modulation signal AF of an acoustic signal and which uses an FM modulated signal f r obtained from the VCXO as a reference signal V r to be input to an analog phase comparator (PC) of a PLL circuit 60. The PC performs a phase comparison operation at a high speed (10 MHz or more), therefore a cutoff frequency of a loop filter (62) may be a high band frequency of about 100 KHz to 1 MHz so that the cutoff frequency considerably higher than the highest audible frequency 20 KHz can be selected. The filter output moves at an inaudible frequency and therefore there is no audible noise generated even due to vibration, feedback, etc. It is also possible to make the charge pump circuit and other steps for shielding against interference and steps for giving resistance to vibration superfluous without adopting the loop filter switching system, therefore a reduction of size and a lowering of cost can be realized.

公开(公告)号：EP1181001A2

公开(公告)日：2002-02-27

申请号：EP00929755.7

申请日：2000-05-24

申请人： Sol-Gel Technologies Ltd.

发明人： LAPIDOT, Noa ,  MAGDASSI, Shlomo ,  AVNIR, David ,  ROTTMAN, Claudio ,  GANS, Orit ,  SERI-LEVY, Alon

IPC分类号： A61K7/00 ,  A61K7/42

CPC分类号： A61K8/042 ,  A61K8/11 ,  A61K8/25 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/445 ,  A61K2800/412 ,  A61Q17/04 ,  Y10S514/962

摘要： The present invention generally relates to safe and stable sunscreen compositions comprising at least one sunscreen active ingredient in the form of an inert sol-gel microcapsules encapsulating ultraviolet absorbing compounds in any acceptable cosmetic vehicle. The composition according to the present invention can comprise several ultraviolet absorbers that may be encapsulated in the same sol-gel microcapsule or in different capsules. The encapsulation of the ultraviolet absorbers reduces or even prevents the contact between the sunscreen compounds and the human tissue, thus reducing various adverse effects that are associated with the use of sunscreens. The encapsulation also reduces or even prevents cross reactivity between the suscreen compounds and the packaging material and between the suscreen compounds and any other component present in the composition, thus enhancing the compositions stability. The hydophobicity/hydrophilicity character of the sol-gel microcapsules can be controlled by selecting suitable sol-gel precursors and suitable reaction conditions and can be chosen to be compatible with the cosmetic vehicle to be used in the sunscreen composition. The sunscreen compositions of the present invention can comprise any acceptable UVA and/or UVB absorbing compounds at any desired ratio to obtain a desired accumulative ultraviolet screening spectrum.

公开(公告)号：EP1181000A1

公开(公告)日：2002-02-27

申请号：EP00929754.0

申请日：2000-05-24

申请人： Sol-Gel Technologies Ltd.

发明人： LAPIDOT, Noa ,  MAGDASSI, Shlomo ,  AVNIR, David ,  ROTTMAN, Claudio ,  GANS, Orit ,  SERI-LEVY, Alon

IPC分类号： A61K7/00 ,  A61K7/42

CPC分类号： A61K8/042 ,  A61K8/11 ,  A61K8/25 ,  A61K8/29 ,  A61K8/35 ,  A61K8/37 ,  A61K8/375 ,  A61K2800/412 ,  A61K2800/52 ,  A61Q17/04 ,  Y10S514/844 ,  Y10S514/944 ,  Y10S514/945 ,  Y10S514/972

摘要： The present invention relates to a method for obtaining improved photostability of a sunscreen composition that contains at least two sunscreen active ingredients, which are photo-unstable when formulated together, by microencapsulating at least one of said active ingredients in an encapsulating material suitable for holding the encapsulated active ingredient material, thus reducing or preventing its leaching out of the capsules; and adding other acceptable components and additives needed for the preparation of said composition. The sunscreen active ingredients can be selected from UVA and UVB absorbers, preferably a combination thereof. In a preferred embodiment of the present invention said active ingredients are encapsulated in separate sol-gel microcapsules.