公开(公告)号：EP3219204A1

公开(公告)日：2017-09-20

申请号：EP17165360.3

申请日：2005-05-02

申请人： Intrexon Corporation

发明人： PALLI, Subba, Reddy ,  KUMAR, Mohan, Basavaraju

IPC分类号： A01K67/00 ,  C07K14/47 ,  C07K19/00 ,  C12N1/00 ,  C12N5/02 ,  C12N5/10 ,  C12N15/12 ,  C12N15/62 ,  C12N15/63 ,  C12P21/02

CPC分类号： C12N15/85 ,  A61K31/16 ,  A61K31/47 ,  C07D215/44 ,  C07H21/04 ,  C07K14/43536 ,  C12N15/62 ,  C12N15/63 ,  C12N15/635 ,  Y10S530/858

摘要： This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.

摘要翻译： 本发明涉及生物技术或基因工程领域。 具体而言，本发明涉及场基因表达。 更具体地说，本发明涉及新的取代突变体受体及其在基于核受体的诱导型基因表达系统中的用途以及调节宿主细胞中基因表达的方法，用于诸如基因治疗，蛋白质的大规模生产和 抗体，基于细胞的高通量筛选测定，功能基因组学和转基因生物中性状的调节。

公开(公告)号：EP2783694A2

公开(公告)日：2014-10-01

申请号：EP14162925.3

申请日：2008-09-05

申请人： Peptcell Limited

发明人： Stoloff, Gregory Alan ,  Caparros-Wanderley, Wilson Romero

IPC分类号： A61K38/01 ,  C07K14/435 ,  A61K39/00 ,  A61K39/005

CPC分类号： C07K14/43577 ,  A61K38/00 ,  A61K39/005 ,  A61K2039/53 ,  Y10S530/806 ,  Y10S530/855 ,  Y10S530/858

摘要： Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells capable of recognising at least one epitope from an arthropod saliva protein fraction, wherein the arthropod saliva protein fraction has a mass of 40kDA or less, and wherein the polypeptides are selected independently from:
the polypeptide sequences of SEQ ID 1-44 or sub-sequences from these sequences, the sub-sequences having 7 amino acids or more; or
from polypeptide sequences having 85% homology or more with one or more of the above sequences and contained in one or more of the following databases: GenBank, Protein Data Bank (PDB), SwissProt, Protein Information Resource (PIR), Protein Research Foundation (PRF), or CDS translations of these.

摘要翻译： 提供了一种多肽组合物，其包含一种或多种多肽，该多肽在脊椎动物中是免疫原性的，使得它们使脊椎动物产生能够识别节肢动物唾液蛋白质级分中的至少一个表位的免疫系统细胞，其中节肢动物唾液蛋白质级分具有 质量为40kDA或更小，并且其中所述多肽独立地选自：SEQ ID 1-44的多肽序列或来自这些序列的亚序列，所述亚序列具有7个氨基酸或更多个; 或来自与一个或多个上述序列具有85％同源性或更多的多肽序列，并且包含在一个或多个以下数据库中：GenBank，蛋白质数据库（PDB），SwissProt，蛋白质信息资源（PIR），蛋白质研究基金会 （PRF）或CDS翻译。

公开(公告)号：EP2407172A1

公开(公告)日：2012-01-18

申请号：EP11178673.7

申请日：2008-09-05

申请人： Peptcell Limited

发明人： Stoloff, Gregory Alan ,  Caparros-Wanderley, Wilson Romero

IPC分类号： A61K38/01 ,  C07K14/435

CPC分类号： C07K14/43577 ,  A61K38/00 ,  A61K39/005 ,  A61K2039/53 ,  Y10S530/806 ,  Y10S530/855 ,  Y10S530/858

摘要： Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells capable of recognising at least one epitope from an arthropod saliva protein fraction, wherein the arthropod saliva protein fraction has a mass of 40kDA or less, and wherein the polypeptides are selected independently from:
the polypeptide sequences of SEQ ID 1-44 or sub-sequences from these sequences, the sub-sequences having 7 amino acids or more; or
from polypeptide sequences having 85% homology or more with one or more of the above sequences and contained in one or more of the following databases: GenBank, Protein Data Bank (PDB), SwissProt, Protein Information Resource (PIR), Protein Research Foundation (PRF), or CDS translations of these.

摘要翻译： 提供了一种多肽组合物，其包含一种或多种多肽，该多肽在脊椎动物中是免疫原性的，使得它们使脊椎动物产生能够识别节肢动物唾液蛋白质级分中的至少一个表位的免疫系统细胞，其中节肢动物唾液蛋白质级分具有 质量为40kDA或更小，并且其中所述多肽独立地选自：SEQ ID 1-44的多肽序列或来自这些序列的亚序列，所述亚序列具有7个氨基酸或更多个; 或来自与一个或多个上述序列具有85％同源性或更多的多肽序列，并且包含在一个或多个以下数据库中：GenBank，蛋白质数据库（PDB），SwissProt，蛋白质信息资源（PIR），蛋白质研究基金会 （PRF）或CDS翻译。

公开(公告)号：EP1385370B1

公开(公告)日：2008-02-20

申请号：EP02726780.6

申请日：2002-04-19

申请人： PIONEER HI-BRED INTERNATIONAL, INC. ,  E. I. DU PONT DE NEMOURS AND COMPANY

发明人： ALTIER, Daniel, J. ,  HERRMANN, Rafael ,  LU, Albert, L. ,  McCUTCHEN, Billy, F. ,  PRESNAIL, James, K. ,  WEAVER, Janine, L. ,  WONG, James, F., H.

IPC分类号： A01H5/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/04 ,  C12N7/01 ,  C12N15/12 ,  C12N15/70 ,  C12N15/74 ,  C12N15/80 ,  C12N15/81 ,  C12N15/82 ,  C07K14/435

CPC分类号： C12N15/8282 ,  C07K14/43563 ,  Y10S530/858

摘要： The methods and compositions of the present invention find use in impacting microbial pathogens and in enhancing disease resistance to pathogens, particularly by plants. The compositions of the invention include polypeptides that possess antimicrobial properties, particularly fungicidal properties, and the encoding nucleic acid molecules. The polypeptides of the invention are isolated from the hemolymph and fat bodies of insect larvae induced by injection of plant pathogenic fungi. Further provided are plant cells, plants, an seed thereof, transformed with the nucleic acid mole cules of the invention so as to confer disease resistance on the plant.

公开(公告)号：EP1049479B1

公开(公告)日：2005-11-16

申请号：EP99900282.7

申请日：1999-01-13

申请人： S.I.S. Shulov Institute for Science Ltd.

发明人： SHULOV, Aharon DI ,  PRIMOR, Naftali S.I.S.Shulov Inst.for Science Ltd.

IPC分类号： A61K35/58 ,  A61P29/02

CPC分类号： A61K35/58 ,  C07K14/46 ,  Y10S530/856 ,  Y10S530/858

摘要： A substantially non-toxic fraction isolated from the venom of Vipera xanthina is disclosed which fraction has an analgesic ef fect. The fraction is preferably purified on an ion exchange column from Vipera xanthina palestinae. Also described are a pharmaceutical composition for use as an analgesic comprising the non-toxic fraction, and a method for the relief of pain comprising administrating the non-toxic fraction.

公开(公告)号：EP1207899B1

公开(公告)日：2004-12-15

申请号：EP00954788.6

申请日：2000-08-24

申请人： Evolutec Limited

发明人： NUTTALL, Patricia, Anne; ,  PAESEN, Guido, Christiaan

IPC分类号： A61K38/17 ,  A61P11/00

CPC分类号： A61K39/35 ,  A61K38/1767 ,  Y10S530/855 ,  Y10S530/858

摘要： The invention relates to the discovery that various proteins isolated from ticks are effective in the treatment and prevention of allergic rhinitis. These proteins may most suitably be applied to an effected area and are thus effective to treat this condition and to ameliorate its symptoms.

公开(公告)号：EP1443054A1

公开(公告)日：2004-08-04

申请号：EP02801557.6

申请日：2002-10-15

申请人： Nissan Chemical Industries, Ltd. ,  National Institute of Agrobiological Sciences

发明人： TOMIE, Tetsuya, Nissan Chemical Industries, Ltd. ,  TAGAWA, Michito, Nissan Chemical Industries, Ltd. ,  YAMAKAWA, Minoru ,  ISHIBASHI, Jun

IPC分类号： C07K14/435 ,  C12N15/12 ,  C12N5/10 ,  C12N15/63 ,  C12P21/02 ,  A01H5/00 ,  A61K38/17 ,  A61P31/04 ,  A01N47/34

CPC分类号： C12N15/8279 ,  A01N37/46 ,  A01N63/00 ,  A01N63/02 ,  C07K14/43563 ,  C12N15/8281 ,  C12N15/8282 ,  Y10S530/858

摘要： It is intended to provide thermotolerant and antimicrobial proteins having a broad antibacterial spectrum and being useful in the agricultural, medical and industrial field; and plants resistant to pathogenic microorganisms. Namely, DNAs comprising the base sequences represented by SEQ ID NOS: 1 to 5 respectively; antimicrobial proteins encoded by these DNAs; and fungicides, antibacterial agents and antibacterial/antifungal agents for industrial use comprising the antimicrobial proteins as the active ingredient.

摘要翻译： 旨在提供具有广泛抗菌谱的耐热和抗微生物蛋白质，并且可用于农业，医疗和工业领域; 和抗病原微生物的植物。 即分别含有由SEQ ID NO：1〜5表示的碱基序列的DNA。 由这些DNA编码的抗微生物蛋白质; 以及包含抗微生物蛋白作为活性成分的杀真菌剂，抗菌剂和工业用抗菌/抗真菌剂。

公开(公告)号：EP1385370A2

公开(公告)日：2004-02-04

申请号：EP02726780.6

申请日：2002-04-19

申请人： PIONEER HI-BRED INTERNATIONAL, INC. ,  E.I. DUPONT DE NEMOURS AND COMPANY

发明人： ALTIER, Daniel, J. ,  HERRMANN, Rafael ,  LU, Albert, L. ,  McCUTCHEN, Billy, F. ,  PRESNAIL, James, K. ,  WEAVER, Janine, L. ,  WONG, James, F., H.

IPC分类号： A01H5/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/04 ,  C12N7/01 ,  C12N15/12 ,  C12N15/70 ,  C12N15/74 ,  C12N15/80 ,  C12N15/81 ,  C12N15/82 ,  C07K14/435

CPC分类号： C12N15/8282 ,  C07K14/43563 ,  Y10S530/858

摘要： The methods and compositions of the present invention find use in impacting microbial pathogens and in enhancing disease resistance to pathogens, particularly by plants. The compositions of the invention include polypeptides that possess antimicrobial properties, particularly fungicidal properties, and the encoding nucleic acid molecules. The polypeptides of the invention are isolated from the hemolymph and fat bodies of insect larvae induced by injection of plant pathogenic fungi. Further provided are plant cells, plants, an seed thereof, transformed with the nucleic acid mole cules of the invention so as to confer disease resistance on the plant.

公开(公告)号：EP1317483A2

公开(公告)日：2003-06-11

申请号：EP01984645.0

申请日：2001-09-11

申请人： CONSIGLIO NAZIONALE DELLE RICERCHE

发明人： STURARO, Monica ,  VIOTTI, Angelo ,  FALAGIANI, Paolo ,  MISTRELLO, Giovanni ,  RONCAROLO, Daniela ,  ZANOTTA, Stefania

IPC分类号： C07K14/435 ,  A61K39/35 ,  C12N15/12 ,  A61K38/17

CPC分类号： A61K31/198 ,  A61K9/0019 ,  A61K31/195 ,  A61K31/335 ,  A61K31/40 ,  A61K31/565 ,  A61K31/70 ,  A61K31/704 ,  A61K38/00 ,  A61K45/06 ,  A61K47/183 ,  C07K14/43531 ,  Y10S530/858 ,  Y10S530/868 ,  A61K2300/00

摘要： Variants of allergens of Dermatophagoides pteronyssinus species with reduced allergenic activity.

公开(公告)号：EP0838999A2

公开(公告)日：1998-05-06

申请号：EP96914565.0

申请日：1996-04-30

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： HAMMOCK, Bruce, D. ,  HERRMANN, Rafael ,  MOSKOWITZ, Haim

IPC分类号： C12N15 ,  A01N63 ,  C07K14 ,  C12N7 ,  C12R1

CPC分类号： C12N15/86 ,  A01N63/02 ,  C07K14/43522 ,  C12N2710/14143 ,  Y10S530/858 ,  A01N2300/00

摘要： A method is provided that accelerates the rate of kill of pests such as from the order Lepidoptera. The method comprises treating the pests or their loci with at least two different insect toxins which are expressed from at least one recombinant microbe. Pairs of toxins that do not compete with each other on the same binding site and that differ in their pharmacology have been found to provide synergistic control. Preferred insecticidal microbes are baculoviruses.