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80 条记录 (耗时 0.02 秒)

    SINGLE UNIT ANTIBODY PURIFICATION
    1.
    发明公开
    SINGLE UNIT ANTIBODY PURIFICATION 审中-公开
    单一单位抗体清洗

    公开(公告)号：EP2534169A1

    公开(公告)日：2012-12-19

    申请号：EP11702653.4

    申请日：2011-02-10

    申请人： DSM IP Assets B.V.

    发明人： KREMER, Diderik Reinder ,  MAARLEVELD, Randal William

    IPC分类号： C07K1/18 ,  C07K1/20 ,  C07K16/06 ,  B01D15/32 ,  B01D15/36

    CPC分类号： B01D15/32 ,  B01D15/327 ,  B01D15/363 ,  C07K1/36 ,  C07K16/00

    摘要： The present invention relates to a method for the purification of antibodies from a protein mixture produced in a bioreactor, at least comprising the steps of intermediate purification and polishing, wherein the intermediate purification and polishing step comprises in-line anion exchange chromatography (AEX) treatment and hydrophobic interaction chromatography (HIC) treatment in flow through mode. The present invention further relates to a single operational unit comprising both an anion exchange chromatography part and a hydrophobic interaction chromatography part, which are serially connected, wherein the unit comprises an inlet at the upstream end of the anion exchange chromatography part and an outlet at the downstream end of the hydrophobic interaction chromatography part and wherein the unit also comprises an inlet between the anion exchange chromatography part and the hydrophobic interaction chromatography part.

    PROCESS FOR THE PREPARATION OF ALKYNOLS
    2.
    发明公开
    PROCESS FOR THE PREPARATION OF ALKYNOLS 有权
    用于生产alkinols

    公开(公告)号：EP1673327A1

    公开(公告)日：2006-06-28

    申请号：EP04790463.6

    申请日：2004-10-14

    申请人： DSM IP Assets B.V.

    发明人： BOXTEL VAN, Danni¬l, Adrianus, Franciscus, Jacobus ,  VERZIJL, Gerardus, Karel, Maria

    IPC分类号： C07C29/00 ,  C07C29/09 ,  C12P41/00

    CPC分类号： C12P7/04 ,  C07C29/00 ,  C07C29/095 ,  C12P9/00 ,  C12P41/007 ,  C07C33/042

    摘要： Process for the preparation of an alkynol with formula HC=C-C(OH)-R2 (formula 2) wherein R2 represents methyl, halomethyl or ethyl, wherein the corresponding silyl-protected alkynol ester with formula 1 (1) wherein R1 represents H, or an optionally substituted alkyl, an optionally substituted alkenyl or an optionally substituted (hetero)aryl group, R2 is as defined above and A3Si represents a trisubstituted silyl group wherein each A independently represents anoptionally substituted alkyl or an optionally substituted (hetero)aryl group, in the presence of water and at least an equivalent amount of amine functionalities is converted into the alkynol with formula 2. Preferably, the amount of water is between 0.5 and 3 equivalents calculated with respect to the amount of silyl-protected alkynol ester with formula (1).

    MEMBRANE FILTRATION
    5.
    发明授权
    MEMBRANE FILTRATION 有权
    MEMBRANFILTRATION

    公开(公告)号：EP1071744B1

    公开(公告)日：2003-06-25

    申请号：EP99919252.9

    申请日：1999-04-14

    申请人： DSM N.V.

    发明人： KWANT, Gerard, Jan ,  DE ZWARTE, Pieter, Johannes, Gerrit

    IPC分类号： C12M1/12

    CPC分类号： C12M29/04 ,  C12M47/10

    摘要： The invention relates to a process for isolating a desired water-soluble product from a fermentation broth wherein the broth is circulated along a ceramic membrane, and wherein a trans-membrane pressure of at least 1.5 bar is applied, whereupon an aqueous solution containing the desired product traverses the membrane, and is subsequently collected. Advantageously, during this filtration process the temperature of the broth is maintained at 20 to 50 °C, preferably at 30 to 45 °C. According to the invention, a decreased process time and a higher capacity and efficiency of the filtration are obtained.

    USE OF LABELLED CCK-B RECEPTOR LIGANDS FOR THE DETECTION AND LOCALIZATION OF MALIGNANT HUMAN TUMOURS
    8.
    发明公开
    USE OF LABELLED CCK-B RECEPTOR LIGANDS FOR THE DETECTION AND LOCALIZATION OF MALIGNANT HUMAN TUMOURS 失效
    TAGGED CCK-B受体配体进行检测和恶性肿瘤的隔离使用MESCHLICHEN

    公开(公告)号：EP0885017A2

    公开(公告)日：1998-12-23

    申请号：EP97908751.0

    申请日：1997-02-25

    申请人： MALLINCKRODT MEDICAL, INC.

    发明人： REUBI, Jean-Claude

    IPC分类号： A61K38 ,  A61K31 ,  A61K49 ,  A61K51 ,  A61P35 ,  C07K7

    CPC分类号： A61K51/083 ,  A61K51/088 ,  A61K2123/00

    摘要： The invention relates to a method of detecting and localizing malignant tumours and their metastases in tissues, which in healthy condition do not contain disturbing quantities of CCK-receptors, in the body of a human being, which comprises (i) administering to said being a composition comprising, in a quantity sufficient for external imaging, a labelled peptide derived from a compound of general formula (I), or an acid amide thereof, formed between a free NH2-group of an amino acid moiety and R1COOH, wherein R1 is a (C1-C3)alkanoyl group, an arylcarbonyl group, or an aryl-(C1-C3)alkanoyl group; or a lactam thereof, formed between a free NH2 group of an amino acid moiety and a free CO2H group of another amino acid moiety; or a conjugate thereof with avidin or biotin; wherein: (Xaa)n stands for 0 to 25 amino acid moieties which are equal or different and are selected from Ala, Leu, Asn, Dpr, Gln, Glu, Ser, Ile, Met, His, Asp, Lys, Gly, Thr, Pro, Pyr, Arg, Tyr, Trp, Val and Phe; m = 0 or 1; Xbb is Asp, Dpr, Glu or Pyr, with the proviso that Xbb can only be Pyr when n=0; Xcc is Met, Leu or Nle; Xdd is Met, Leu or Nle; and R2 is a hydroxy group, an acetoxy group or an amino group; and thereupon (ii) subjecting said being to external imaging, by radioactive scanning or by magnetic resonance imaging, to determine the targeted sites in the body of said being. The invention further relates to a method for the therapeutic treatment of said malignant tumours by administration of the above-defined peptide, labelled for this purpose. The invention also relates to a method for labelling of the peptide compounds, to a pharmaceutical composition to be used for detection, to a pharmaceutical composition to be used for therapy and to a kit for preparing a radiopharmaceutical composition.

    Use of Mebeverine against non-specific inflammatory bowel disease
    10.
    发明公开
    Use of Mebeverine against non-specific inflammatory bowel disease 失效
    Verwendung von Mebeverin gegen unspezifischeEntzündungserkrankungendes Darmes。

    公开(公告)号：EP0528076A1

    公开(公告)日：1993-02-24

    申请号：EP91202116.9

    申请日：1991-08-20

    申请人： DUPHAR INTERNATIONAL RESEARCH B.V

    发明人： Vantrappen,G

    IPC分类号： A61K31/235

    CPC分类号： A61K31/235 ,  A61K31/24

    摘要： The present invention is concerned with medicaments effective against non-specific inflammatory bowel disease, such as as ulcerative colitis and Crohn's disease, containing mebeverine.

    摘要翻译： 本发明涉及对非特异性炎症性肠病有效的药物，例如含有美贝维林的溃疡性结肠炎和克罗恩病。