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    A DEVICE FOR USE IN ANGLING FOR RELEASABLY OR NON-RELEASABLY RETAINING A WEIGHT
    1.
    发明公开
    A DEVICE FOR USE IN ANGLING FOR RELEASABLY OR NON-RELEASABLY RETAINING A WEIGHT 审中-实审

    公开(公告)号：EP4388871A1

    公开(公告)日：2024-06-26

    申请号：EP23180141.6

    申请日：2023-06-19

    申请人： Korda Developments Limited

    发明人： Grundy, Richard Allen

    IPC分类号： A01K95/02

    CPC分类号： A01K95/02

    摘要： A device (2) for use in angling for releasably or non-releasably retaining a weight (4), which device (2) comprises:
    (i) a body portion (6);
    (ii) a receiving formation (8) in the body portion (6); and
    (iii) a spring member in the receiving formation (6), and wherein:
    (iv) the receiving formation (8) is longitudinally slidable over the spring member (8);
    (v) the receiving formation (8) is rotatably slidable over the spring member (10) in order cause the spring member (10) to function in a first mode of use or a second mode of use, and with an angler always being able to choose between the first mode of use or the second mode of use;
    (vi) in the first mode of use, the spring member (10) has a first longitudinal position in the receiving formation (8) and which is such as to cause the weight (4) to be retained by the spring member (10);
    (vii) in the first mode of use, the spring member (10) has a second longitudinal position in the receiving formation (8) and which is such as to cause the weight (4) to be releasable from the spring member (10); and
    (viii) in the second mode of use, both the first and second longitudinal positions of the spring member (10) in the receiving formation (8) are such as to cause the weight (4) to be retained by the spring member (10).

    PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND INTERMEDIATE COMPOUNDS
    5.
    发明公开
    PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND INTERMEDIATE COMPOUNDS 审中-公开
    VERFAHREN ZUR HERSTELLUNG VON SITAGLIPTIN SOWIE ZWISCHENPRODUKTEN DAVON

    公开(公告)号：EP2882752A1

    公开(公告)日：2015-06-17

    申请号：EP13750356.1

    申请日：2013-08-08

    申请人： Cipla Limited

    发明人： RAO, Dharmaraj, Ramachandra ,  KANKAN, Rajendra, Narayanrao ,  GHAGARE, Maruti ,  KADAM, Swati, Atul

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： There is provided a process for the preparation of sitagliptin or a pharmaceutically acceptable salt thereof, and a process for the preparation of intermediate compounds useful in the preparation of sitagliptin. In particular, there is provided a process comprising condensing 3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl) butyric acid of formula (II) with 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[l,2,4]triazolo[4,3-a] pyrazine of formula (III) or a salt thereof in presence of a catalyst to obtain (R)-tert-butyl-4-oxo-4-(3- (trifluoromethyl)-5,6-dihydro-[ 1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl)- 1 -(2,4,5- trifluorophenyl)butan-2-yl-carbamate of formula (IV) or a pharmaceutically acceptable salt thereof. The catalyst is represented by the compound of formula (V). Compound of formula (IV) or its pharmaceutically acceptable salt obtained may be deprotected to obtain a compound of formula (I).

    摘要翻译： 提供了西他列汀或其药学上可接受的盐的制备方法，以及制备可用于制备西格列汀的中间体化合物的方法。 特别地，提供了一种方法，其包括将式（II）的3-叔丁氧基羰基氨基-4-（2,4,5-三氟苯基）丁酸与3-（三氟甲基）-5,6,7,8-四氢 - [1,2,4]三唑并[4,3-a]吡嗪或其盐在催化剂存在下反应，得到（R） - 叔丁基-4-氧代-4-（3- （三氟甲基）-5,6-二氢 - [1,2,4] - 三唑并[4,3-a]吡嗪-7（8H） - 基）-1-（2,4,5-三氟苯基）丁-2- （Ⅳ）的 - - - - 氨基甲酸酯或其药用盐。 催化剂由式（V）化合物表示。 可以将得到的式（IV）化合物或其药学上可接受的盐脱保护，得到式（I）化合物。

    AMINE AND NITROXIDE BASED ADDITIVE COMPOSITION FOR CONTROL AND INHIBITION OF POLYMERIZATION OF STYRENE, AND METHOD OF USE THEREOF
    6.
    发明公开
    AMINE AND NITROXIDE BASED ADDITIVE COMPOSITION FOR CONTROL AND INHIBITION OF POLYMERIZATION OF STYRENE, AND METHOD OF USE THEREOF 有权
    阿明NITROXIDBASIERTE添加剂组合物为使用的控制和苯乙烯的阻聚和方法

    公开(公告)号：EP2785780A1

    公开(公告)日：2014-10-08

    申请号：EP12839189.3

    申请日：2012-11-21

    申请人： Dorf Ketal Chemicals (India) Private Limited

    发明人： SUBRAMANIYAM, Mahesh

    IPC分类号： C08K5/17 ,  C08K5/32

    CPC分类号： C09K15/20 ,  C07C7/20 ,  C08F2/40 ,  C08F2438/02 ,  C08K5/17 ,  C08K5/32 ,  C07C15/46 ,  C08F12/08

    摘要： The present invention relates to additive composition for controlling and inhibition of polymerization of aromatic vinyl monomers including styrene comprising: (a) one or more of nitroxide (i.e. nitroxyl) compounds; and characterized in that the said composition further comprises one or more of (b) aliphatic amines selected from a group comprising tertiary amines, secondary amines and primary amines. In one embodiment, the present invention also relates to method of use of presently provided composition. In another embodiment, the present invention also relates to method of controlling and inhibiting polymerization of aromatic vinyl monomers including styrene by employing presently provided composition. In still another embodiment, the present invention also relates to method of preparation of presently provided composition.

    摘要翻译： 本发明涉及一种添加剂组合物，用于控制和芳族乙烯基单体包括苯乙烯，其包括聚合的抑制（a）一种或多种氮氧化物（即硝酰基）的化合物，和在DASS特点死所述组合物进一步包含一种或多种（b）的 从一组包含叔cardamines，仲和伯cardamines cardamines选择脂族cardamines。 在一个，在本实施方式本发明因此涉及使用本发明提供的组合物的方法。 在另一个中，本实施方式本发明因此涉及一种控制和抑制乙烯基芳族单体的苯乙烯通过采用本发明提供的组合物包含的聚合方法。 在另一无声实施方案，本发明因此涉及制备本发明提供的组合物的方法。

    ADDITIVE COMPOSITION FOR CONTROL AND INHIBITION OF POLYMERIZATION OF STYRENE, AND METHOD OF PREPARATION AND USE THEREOF
    7.
    发明公开
    ADDITIVE COMPOSITION FOR CONTROL AND INHIBITION OF POLYMERIZATION OF STYRENE, AND METHOD OF PREPARATION AND USE THEREOF 有权
    控制添加剂组合物和苯乙烯的阻聚及其制备方法和使用方法

    公开(公告)号：EP2748207A1

    公开(公告)日：2014-07-02

    申请号：EP12816798.8

    申请日：2012-08-17

    申请人： Dorf Ketal Chemicals (India) Private Limited

    发明人： SUBRAMANIYAM, Mahesh

    IPC分类号： C08F2/40 ,  C08F12/08 ,  C07C7/20

    CPC分类号： C07C15/46 ,  C07C7/20 ,  C08F12/08 ,  C09K15/24 ,  C08F2/40

    摘要： The present invention relates to additive composition for control and inhibition of polymerization of styrene, wherein the composition comprises amine and quinone methide, and wherein the amine is polymerization non-inhibitor amine. In one embodiment, the present invention relates to method of preparation and use of additive composition to control and inhibit polymerization of styrene, wherein the composition comprises amine and quinone methide, and wherein the amine is polymerization non-inhibitor amine. In another embodiment, the present invention relates to additive composition for control and inhibition of polymerization of styrene, wherein the composition comprises oxide treated derivative of amine and quinone methide, and wherein the am ine is polymerization non-inhibitor amine, and to the method of preparation and use thereof.