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公开(公告)号：EP0934414A1
公开(公告)日：1999-08-11
申请号：EP98913911.0
申请日：1998-03-25
发明人： BEELEY, Lee, James, SmithKline Beecham Pharm. , MATHIAS, Stephen, Lee, SmithKline Beecham Pharm.
摘要： HKAFE42 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HKAFE42 polypeptides and polynucleotides in the design of protocols for the treatment of disorders of the central nervous system (including anxiety, depression, schizophrenia and Parkinson's disease), muscle diseases (including muscular dystrophies and multiple sclerosis), Alzheimer's disease, hematopoetic disorders, allergic diseases, autoimmune diseases, immunodeficiency and cancer, among others, and diagnostic assays for such conditions.
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公开(公告)号：EP0907729A1
公开(公告)日：1999-04-14
申请号：EP96912122.0
申请日：1996-04-30
发明人： McHALE, Mark, Thomas , TOMLINSON, William, J. , LIVINGSTONE, Craig, D. , CARPENTER, David, J. , YI, Li
IPC分类号： G01N33 , A61K31 , A61K38 , A61K45 , A61K48 , A61P25 , C07K14 , C12N1 , C12N5 , C12N15 , C12P21
CPC分类号： G01N33/6872 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/705 , C07K2319/00 , C07K2319/02 , G01N2333/705 , G01N2500/00
摘要： The invention discloses polynucleotides sequences coding for splice-variants of the human brain P2x4 receptor. The invention concerns also the recombinant expression of said receptors and their use for screening of antagonists.
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公开(公告)号：EP0871669A1
公开(公告)日：1998-10-21
申请号：EP95943863.0
申请日：1995-12-15
CPC分类号： C07K14/723 , A61K38/00
摘要： This invention relates to a novel human somatostatin-like receptor, isolated nucleic acids encoding same, recombinant host cell transformed with a somatostatin-like receptor encoding DNA and to uses of the expressed receptor and nucleic acid sequences in drug screening and development as well as in therapeutic and diagnostic applications.
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公开(公告)号：EP0869943A1
公开(公告)日：1998-10-14
申请号：EP96943110.0
申请日：1996-12-04
发明人： HICKEY, Deirdre, M.B.- SmithKline Beecham Pharm. , DHANAK, Dashyant-SmithKline Beecham Pharmaceutic. , IFE, Robert, John-SmithKline Beecham Pharmaceutic , LEACH, Colin Andrew, SmithKline Beecham Pharmac. , TEW, David, Graham, SmithKline Beecham Pharmac.
CPC分类号： C07D405/12 , C07D205/08 , C07D205/09
摘要： Compounds of formula (I) are prodrugs of the corresponding compounds in which CO2R3 is CO¿2?H. These are inhibitors of the phospholipase A2 enzyme Lp-PLA2 and of use in treating atherosclerosis.
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公开(公告)号：EP0865429A1
公开(公告)日：1998-09-23
申请号：EP96942375.0
申请日：1996-12-04
发明人： HICKEY, Deirdre, Mary, Bernadette , DHANAK, Dashyant , IFE, Robert, John , LEACH, Colin, Andrew , TEW, David, Graham
IPC分类号： A61K31 , A61P3 , A61P9 , A61P17 , A61P25 , A61P29 , A61P43 , C07D205 , C07D401 , C07D413 , C07D417
CPC分类号： C07D401/14 , C07D205/09 , C07D413/06 , C07D413/12 , C07D417/12
摘要： Azetidinone compounds of formula (I) in which inter alia: R?0 is CR4R5-X1-Y1¿ or (CH¿2?)pX?2(CH¿2)qY?2; R4 and R5¿ which may be the same or different is each selected from hydrogen and C¿(1-6)?alkyl, or R?4 and R5¿ may be linked together to form the residue of a C¿(3-7)?cycloalkyl ring; X?1¿ is a linker group and Y1 is optionally substituted C¿(1-12)?alkyl C(2-12)alkynyl, C(2-12)alkynyl, C(3-7)-cycloalkylC(1-8) alkyl or an optionally substituted heteroaryl group; and X?2¿ is a heteroaryl group and Y2 is an optionally substituted aryl group, p is an integer from 1 to 6, q is 0 or an integer from 1 to 6; are inhibitors of the phospholipase A2 enzyme Lp PLA2 and are of use in therapy, for instance in treating atherosclerosis.
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公开(公告)号：EP0840725A1
公开(公告)日：1998-05-13
申请号：EP96922030.0
申请日：1996-06-20
发明人： DHANAK, Dashyant, SmithKline Beecham Pharma. , HICKEY, Deirdre, M.B., SmithKline Beecham Pharma. , IFE, Robert, J., SmithKline Beecham Pharmaceuticls , LEACH, Colin, A., SmithKline Beecham Pharma. , TEW, David, G., SmithKline Beecham Pharmaceuticals
CPC分类号： C07D401/12 , C07D205/085 , C07D205/095 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Azetidinone compounds of formule (I) in which: R?1 and R2¿, which may be the same or different, is each selected from hydrogen, halogen or C¿(1-8)?alkyl; R?4 and R5¿ which may be the same or different is each selected from hydrogen, C¿(1-6)?alkyl, C(2-6)alkenyl, aryl, aryl(C1-4)alkyl and heteroaryl(C1-4)alkyl each of which may be optionally substituted or R?4 and R5¿ may be linked together to form the remainder of a (C¿3-7?)cycloalkyl ring; X is a linker group; Y is an optionally substituted aryl group; Z is oxygen and R?3¿ is C¿(1-8)?alkyl, C(3-8)cycloalkyl, C(3-8)cycloalkylC(1-6)alkyl, heteroaryl, heteroaryl(C1-4)alkyl, aryl, or aryl(C1-4)alkyl, each of which may be optionally substituted or Z is S(O)n in which n is 0, 1 or 2 and R?3¿ is C¿(1-8)?alkyl, C(3-8)cycloalkyl, C(3-8)cycloalkylC(1-6)alkyl, aryl, aryl(C1-4)alkyl, heteroaryl, or heteroaryl(C1-4)alkyl, each of which may be optionally substituted are inhibitors of the enzyme Lp PLA2 and are of use in therapy, in particular treating atherosclerosis.
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公开(公告)号：EP0776205A1
公开(公告)日：1997-06-04
申请号：EP95929820.0
申请日：1995-08-08
发明人： MERRIFIELD, David R., SmithKline Beecham Pharm , WHITE, Steven, SmithKline Beecham Pharmaceut. , RIVETT, Ernest L.G., SmithKline Beecham Pharmaceut
CPC分类号： A61K45/06 , A61K9/2081 , A61K9/5073 , A61K31/43 , A61K31/42 , A61K2300/00
摘要： Pharmaceutical formulations for oral administration, comprising an antibiotic and a β-lactamase inhibitor in the form of a core which comprises a β-lactam antibiotic and a β-lactamase inhibitor, and a surrounding layer around the core.
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8.发明公开PHARMACEUTICAL FORMULATIONS CONTAINING BETA-LACTAM ANTIBIOTICS AND AN ALKYL SULPHATE SURFACTANT 失效药物制剂含有β-内酰胺类抗生素和表面ROYAL烷基硫酸盐
公开(公告)号：EP0751771A1
公开(公告)日：1997-01-08
申请号：EP95928859.0
申请日：1995-03-20
CPC分类号： A61K9/1617 , A61K9/5026
摘要： Pharmaceutical formulations, in particular beta-lactam antibiotic formulations in the form of substantially spherical granules, using a metal alkyl sulphate as a spheronizing agent.
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公开(公告)号：EP0734398A1
公开(公告)日：1996-10-02
申请号：EP95906637.0
申请日：1994-12-15
CPC分类号： C08F8/42 , B01J2219/00497 , C07F7/0812 , C07F7/0818 , C40B40/00
摘要： This invention relates to libraries of non-peptide compounds each comprised of a core structure and methods for making such libraries. This invention also relates to novel silicon-based polymer resins and silane linkers, methods for their preparation and their use in the synthesis of libraries of compounds to be screened as pharmaceutical agents.
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10.发明公开DEOXYTHIOMARINOL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS MICROBICIDES AND HERBICIDES 失效DEOXYTHIOMARINOL衍生物，过程和它们的中间产品及其使用的AS除草剂和杀菌剂
公开(公告)号：EP0698027A1
公开(公告)日：1996-02-28
申请号：EP94917614.0
申请日：1994-05-10
发明人： BAGGALEY, Keith Howard , BEST, Desmond John , BROOM, Nigel John Perryman , O'HANLON, Peter John , OSBORNE, Neal Frederick
CPC分类号： C07D495/04 , A01N43/90 , A01N49/00 , C07D309/16
摘要： Ester derivatives of monic acid of formula (I) comprising a terminal pyrrothine moiety have useful anti-bacterial, anti-fungal and herbicibal properties. Intermediates have been claimed or well.
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