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公开(公告)号：EP2528621B1
公开(公告)日：2016-09-21
申请号：EP11700859.9
申请日：2011-01-27
CPC分类号： C07K14/35 , A61K39/04 , C07K2319/00
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公开(公告)号：EP1896065B2
公开(公告)日：2014-09-03
申请号：EP06754611.9
申请日：2006-06-23
IPC分类号： A61K39/095 , A61K39/102 , A61K39/116 , A61P31/04 , C07K17/10
CPC分类号： A61K39/385 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/145 , A61K39/292 , A61K2039/545 , A61K2039/55 , A61K2039/575 , A61K2039/6037 , A61K2039/62 , A61K2039/627 , A61K2039/70 , C07H3/00 , C12N7/00 , C12N2730/10134 , C12N2760/16234 , C12N2760/16271 , C12N2770/32634 , Y02A50/466 , Y02A50/472 , Y02A50/484
摘要： The present application discloses an immunogenic composition comprising a Hib saccharide conjugate and at least two further bacterial saccharide conjugates wherein the Hib conjugate is present in a lower saccharide dose than the mean saccharide dose of all the at least two further bacterial saccharide conjugates.
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公开(公告)号：EP2426141A3
公开(公告)日：2012-08-15
申请号：EP11190079.1
申请日：2006-04-27
发明人： Marchand, Martine
CPC分类号： A61K39/04 , A61K31/4409 , A61K31/496 , A61K2039/523 , A61K2039/53 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/575 , C07K14/35
摘要： The present invention provides polypeptides, polynucleotides comprising a nucleic acid sequence encoding said polypeptides and related pharmaceutical compositions.
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4.发明公开Novel method for preventing or treating m tuberculosis infection 有权Neues Verfahren zur Vorbeugung oder Behandlung einer Infektion mit M. tuberculosis
公开(公告)号：EP2457926A1
公开(公告)日：2012-05-30
申请号：EP11190080.9
申请日：2006-04-27
发明人： Coler, Rhea , Lobet, Yves , Reed, Steven
CPC分类号： A61K39/04 , A61K31/4409 , A61K31/496 , A61K2039/523 , A61K2039/53 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/575 , C07K14/35
摘要： The present invention is directed to methods of preventing reactivation of active and latent M. tuberculosis infections by administering a pharmaceutical composition comprising a nucleic acid encoding a Mtb72f fusion protein, or a Mtb72f fusion protein or an immunogenic fragment thereof, for example together with an adjuvant. The Mtb72f nucleic acid or fusion protein can be administered with one or more chemotherapeutic agents effective against a M. tuberculosis infection. The methods also provide for shortening the time course of a chemotherapeutic regimen against a M. tuberculosis infection.
摘要翻译： 本发明涉及通过施用包含编码Mtb72f融合蛋白或Mtb72f融合蛋白或其免疫原性片段的核酸的药物组合物，例如与佐剂一起施用来防止活性和潜伏性结核分枝杆菌感染的再活化的方法 。 Mtb72f核酸或融合蛋白可以与一种或多种针对结核分枝杆菌感染有效的化学治疗剂一起施用。 所述方法还提供了缩短针对结核分枝杆菌感染的化疗方案的时间过程。
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公开(公告)号：EP2445526A1
公开(公告)日：2012-05-02
申请号：EP10724879.1
申请日：2010-06-24
发明人： BAUDOUX, Guy Jean Marie Fernand Pierre , BLAIS, Normand , CYR, Sonya L , RHEAULT, Patrick , RUELLE, Jean Louis
IPC分类号： A61K39/155 , C07K14/135
CPC分类号： A61K39/155 , A61K39/12 , A61K2039/55505 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , C07K14/005 , C07K2319/70 , C07K2319/73 , C12N2760/18522 , C12N2760/18534
摘要： This disclosure provides recombinant respiratory syncytial virus (RSV) antigens and methods for making and using them, including immunogenic compositions (e.g., vaccines) for the treatment and/or prevention of RSV infection.
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公开(公告)号：EP2324062A1
公开(公告)日：2011-05-25
申请号：EP09797331.7
申请日：2009-07-17
发明人： BLAIS, Normand , RHEAULT, Patrick
IPC分类号： C07K19/00 , A61K39/155 , A61K39/385 , A61P31/14 , A61P37/04 , C07K14/135 , C12N15/44 , C12N15/62
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2760/18522 , Y02A50/466
摘要： Chimeric respiratory syncytial virus (RSV) polypeptide antigens are provided. The disclosed polypeptides include a first amino acid sequence comprising an F2 domain uncleavably joined to an F1 domain of a Respiratory Syncytial Virus (RSV) Fusion (F) protein polypeptide; and a second amino acid sequence comprising a portion of an RSV Attachment (G) protein polypeptide comprising an immunologically dominant epitope. The disclosure also provides nucleic acids that encode, and pharmaceutical compositions that contain, the chimeric RSV polypeptides, as well as methods for their production and use.
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公开(公告)号：EP2324050A1
公开(公告)日：2011-05-25
申请号：EP09782306.6
申请日：2009-08-28
IPC分类号： C07K14/16 , C07K14/445 , C12N15/861 , A61K39/00
CPC分类号： A61K39/015 , A01K2207/15 , A01K2217/15 , A01K2267/0337 , A61K39/12 , A61K39/21 , A61K2039/525 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/57 , C12N2740/16034 , C12N2760/18443 , Y02A50/412
摘要： The present invention relates, inter alia, to a method of raising an immune response against a pathogen which comprises administering (i) one or more first immunogenic polypeptides derived from said pathogen; (ii) one or more viral vectors comprising one or more heterologous polynucleotides encoding one or more second immunogenic polypeptides derived from said pathogen; and (iii) an adjuvant; wherein the one or more first immunogenic polypeptides, the one or more viral vectors and the adjuvant are administered concomitantly. The invention also relates to vaccines, pharmaceutical compositions, kits and uses employing said polypeptides, viral vectors and adjuvants.
摘要翻译： 本发明尤其涉及一种提高针对病原体的免疫应答的方法，其包括施用（i）一种或多种源自所述病原体的第一免疫原性多肽; （ii）一种或多种病毒载体，其包含编码一种或多种源自所述病原体的第二免疫原性多肽的一种或多种异源多核苷酸; 和（iii）佐剂; 其中所述一种或多种第一免疫原性多肽，所述一种或多种病毒载体和所述佐剂同时施用。 本发明还涉及使用所述多肽，病毒载体和佐剂的疫苗，药物组合物，试剂盒和用途。
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公开(公告)号：EP1265915B1
公开(公告)日：2010-11-10
申请号：EP01929345.5
申请日：2001-02-16
发明人： CABEZON-SILVA, T.E.V., SmithKline Beecham Bio. SA , CASSART, J.P., SmithKline Beecham Biologicals SA , COCHE, Thierry, SmithKline Beecham Biologicals SA , GAULIS, S.R.J.T., SmithKline Beecham Bio. SA , VINALS Y DE BASSOLS, C., SmithKline Beecham Bio.SA
IPC分类号： C07K14/00
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K14/82
摘要： CASB7439 polypeptides and polynucleotides, immunogenic compositions comprising them and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing CASB7439 polypeptides and polynucleotides in diagnostics, and vaccines for prophylactic and therapeutic treatment of cancers, particularly colorectal cancers, autoimmune diseases, and related conditions.
摘要翻译： 公开了CASB7439多肽和多核苷酸，包含它们的免疫原性组合物和通过重组技术产生此类多肽的方法。 还公开了在诊断中使用CASB7439多肽和多核苷酸的方法，以及用于癌症，特别是结肠直肠癌，自身免疫疾病和相关病症的预防和治疗性治疗的疫苗。
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公开(公告)号：EP1326638B9
公开(公告)日：2008-02-20
申请号：EP01987671.3
申请日：2001-10-16
发明人： GARCON, Nathalie, GlaxoSmithKline Biologicals sa , GERARD, Catherine Marie, Ghislaine, SmithKline Beecham , STEPHENNE, Jean, SmithKline Beecham Biologicals SA
IPC分类号： A61K39/39
CPC分类号： A61K39/0011 , A61K2039/55561 , A61K2039/55577 , A61K2039/55583 , A61K2039/6068
摘要： The present invention provides novel adjuvant formulations for use with cancer antigens. The adjuvant comprises a saponin and a immunostimulatory oligonucleotide.
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公开(公告)号：EP0955059B1
公开(公告)日：2007-09-19
申请号：EP99201323.5
申请日：1996-04-01
CPC分类号： A61K39/015 , A61K39/12 , A61K39/245 , A61K39/292 , A61K39/39 , A61K2039/54 , A61K2039/55505 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , C12N2710/16634 , C12N2730/10134 , Y02A50/412 , Y02A50/464
摘要： The invention relates to a vaccine composition comprising a antigen, an immunologically active saponin fraction and a sterol.
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