公开(公告)号：EP2174665B1

公开(公告)日：2016-11-16

申请号：EP10001123.8

申请日：2004-10-22

申请人： ID Biomedical Corporation of Quebec

发明人： Lowell, George H. ,  Burt, David S. ,  Jones, David H. ,  Zimmermann, Joseph J. ,  Rioux, Clement

IPC分类号： A61K39/39 ,  A61K39/112 ,  A61K39/095 ,  A61P11/06 ,  A61P37/00

CPC分类号： A61K39/095 ,  A61K35/74 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/145 ,  A61K39/165 ,  A61K39/39 ,  A61K2039/55544 ,  A61K2039/55572 ,  A61K2039/57 ,  A61K2039/6037 ,  C07K14/005 ,  C07K14/22 ,  C12N2710/24143 ,  Y02A50/394

摘要： Methods for making and using therapeutic formulations of Proteosome-based immunoactive compositions are provided. The immunogenic compositions, which include Proteosomes and liposaccharides, may be used to elicit or enhance a nonspecific innate immune response to, for example, treat or prevent infectious disease. In addition, after activating the innate immune system, immunogenic compositions further containing an antigen may be used to elicit a specific adaptive immune response. Furthermore, provided are compositions capable of altering hyperreactive responses or inflammatory immune responses, such as allergic reactions. Such compositions may be used as a prophylactic, or in various clinical settings to treat or prevent infectious disease (such as parasite, fungal, bacterial or viral infections), or to alter inappropriate inflammatory immune responses (such as allergic reactions or asthma.

公开(公告)号：EP2222710B8

公开(公告)日：2016-10-12

申请号：EP08864495.0

申请日：2008-12-23

申请人： ID Biomedical Corporation of Quebec ,  GlaxoSmithKline Biologicals S.A.

发明人： BAUDOUX, Jean-Pierre ,  BLAIS, Normand ,  RHEAULT, Patrick ,  RUELLE, Jean-Louis

IPC分类号： C07K19/00 ,  A61K39/00 ,  A61K39/155 ,  A61K39/295 ,  A61K9/107 ,  A61K9/127 ,  A61P31/14 ,  A61P37/04 ,  C07K14/135 ,  C12N15/45 ,  C12N15/62 ,  C07K14/005

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/55577 ,  C07K16/1027 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2319/73 ,  C12N2760/18522 ,  C12N2760/18534 ,  Y02A50/466

摘要： This disclosure provides recombinant respiratory syncytial virus (RSV) antigens and methods for making and using them, including immunogenic compositions (e.g., vaccines) for the treatment and/or prevention of RSV infection.

公开(公告)号：EP2066358A1

公开(公告)日：2009-06-10

申请号：EP07838884.0

申请日：2007-09-26

申请人： ID Biomedical Corporation of Quebec ,  Le Group Enico, Inc.

发明人： DUTIL, Frederic ,  OLIVEIRA, George ,  PELLETIER, Nadine ,  POULIN, Micheline ,  TSCHUMAKOW, Alexander, George

IPC分类号： A61L2/00 ,  A61L2/10

CPC分类号： A61L2/0011

摘要： A device (100) for irradiating a fluid is disclosed. The device (100) includes an elongated tube (106) having a fluid injection port (106a) and a fluid discharge port (106b), wherein the elongated tube (106) is rotatable about a longitudinal axis (107). The longitudinal axis (107) extends at an angle oblique to the horizontal. A source of radiation (116) extends within the elongated tube (106) along the longitudinal axis (107). A sleeve (146) extends within the elongated tube (106) and surrounds a length of the source of radiation (116), thereby defining an airflow path between the source of radiation (116) and the sleeve (146). An air flow source (164) is in fluid communication with the airflow path proximate to the fluid injection port (106a). An air flow discharge (180) is in fluid communication with the airflow path proximate to the fluid discharge port (106b). The fluid injection port (106a) and the fluid discharge port (106b) are in communication with the space between the tube (106) and the sleeve ( 146). A method of inactivating a virus and an inactivated virus manufactured according to the method are also disclosed.

公开(公告)号：EP1721618A2

公开(公告)日：2006-11-15

申请号：EP06013179.4

申请日：2001-02-15

申请人： ID Biomedical Corporation of Quebec

发明人： Burt, David S. ,  Lowell, George H. ,  White, Gregory Lee ,  Fries, Louis F., III ,  Jones, David Hugh ,  Torossian, Kirkor ,  Plante, Martin

IPC分类号： A61K39/39 ,  A61K39/145 ,  A61K39/12 ,  A61K39/295 ,  A61P31/12 ,  A61P31/16

CPC分类号： A61K39/39 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5252 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/70 ,  C12N2760/16134 ,  C12N2760/16234

摘要： Improved forms of vaccines which comprise proteosomes and protein antigens are described. Vaccines which contain influenza IIA as the antigen are used for illustration as to demonstrate efficacy. Improvements in the preparation of the vaccines themselves and the proteosome component are also included

摘要翻译： 描述了包含蛋白质体和蛋白质抗原的改进形式的疫苗。 含有IIA型流感疫苗作为抗原的疫苗用于说明效力。 还包括疫苗本身和蛋白质组分的制备的改进

公开(公告)号：EP1372706A2

公开(公告)日：2004-01-02

申请号：EP02713807.2

申请日：2002-03-11

申请人： ID Biomedical Corporation of Quebec ,  Jones, David

发明人： BURT, David, S. ,  LOWELL, George, H. ,  WHITE, Gregory, L. ,  JONES, David ,  RIOUX, Clement

IPC分类号： A61K39/02 ,  A61K39/108 ,  A61K39/12 ,  A61K39/095 ,  A61K39/116 ,  A61K39/385 ,  C07H1/00 ,  C07K1/00

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/145 ,  A61K39/36 ,  A61K39/39 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55572 ,  A61K2039/70 ,  C12N2760/16134 ,  C12N2760/16151

摘要： An adjuvant complex composed of bacterial outer membrane protein proteosomes complexed to bacterial liposaccharide is prepared to contain the component parts under a variety of conditions. The complex can be formulated with antigenic material to form immunogenic compositions, vaccines and immunotherapeutics. An induced immune response includes protective antibodies and/or type 1 cytokines is shown for a variety of protocols.

公开(公告)号：EP2088197B1

公开(公告)日：2016-06-08

申请号：EP09159896.1

申请日：2001-10-02

申请人： ID Biomedical Corporation of Quebec

发明人： Hamel, Josée ,  Couture, France ,  Brodeur, Bernard R. ,  Martin, Denis ,  Ouellet, Catherine ,  Tremblay, Mireille ,  Charbonneau, Annie ,  Vayssier, Catherine

IPC分类号： C12N15/31 ,  C12N15/63 ,  C07K14/285 ,  C07K19/00 ,  A61K39/102 ,  G01N33/569

CPC分类号： C07K14/285 ,  A61K38/00 ,  A61K39/102 ,  C07K2319/00

公开(公告)号：EP2445526B1

公开(公告)日：2016-05-11

申请号：EP10724879.1

申请日：2010-06-24

申请人： GlaxoSmithKline Biologicals S.A. ,  ID Biomedical Corporation of Quebec

发明人： BAUDOUX, Guy Jean Marie Fernand Pierre ,  BLAIS, Normand ,  CYR, Sonya L ,  RHEAULT, Patrick ,  RUELLE, Jean Louis

IPC分类号： A61K39/155 ,  C07K14/135

CPC分类号： A61K39/155 ,  A61K39/12 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  C07K14/005 ,  C07K2319/70 ,  C07K2319/73 ,  C12N2760/18522 ,  C12N2760/18534

公开(公告)号：EP2280072B1

公开(公告)日：2015-03-25

申请号：EP10180962.2

申请日：1999-02-17

申请人： ID Biomedical Corporation of Quebec

发明人： Brodeur, Bernard R. ,  Rioux, Clement ,  Boyer, Martine ,  Charlebois, Isabelle ,  Hamel, Josée ,  Martin, Denis

IPC分类号： C12N15/31 ,  C07K14/315 ,  A61K39/09 ,  C12N1/21

CPC分类号： C07K14/315 ,  A61K39/00

公开(公告)号：EP2261358B1

公开(公告)日：2014-05-14

申请号：EP10180372.4

申请日：1999-12-20

申请人： ID Biomedical Corporation of Quebec

发明人： Brodeur, Bernard R ,  Charland, Nathalie ,  Hamel, Josee ,  Martin, Denis ,  Pineau, Isabelle ,  Rioux, Clement

IPC分类号： A61K39/09 ,  C12N15/62 ,  C07K14/315

CPC分类号： C07K14/3156 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00

公开(公告)号：EP1660660B1

公开(公告)日：2013-07-24

申请号：EP04761674.3

申请日：2004-08-16

申请人： ID Biomedical Corporation of Quebec

发明人： RIOUX, Stéphane ,  MARTIN, Denis ,  HAMEL, Josée ,  BRODEUR, Bernard, R. ,  RHEAULT, Patrick ,  DROUIN, Nathalie

IPC分类号： C12N15/31 ,  C07K14/315 ,  C12P21/02 ,  C12N15/63 ,  C07K19/00 ,  A61K39/09 ,  A61P31/04 ,  G01N33/569 ,  A61K38/16

CPC分类号： A61K39/092 ,  A61K38/00 ,  A61K2039/53 ,  A61K2039/55577 ,  C07K14/315 ,  C07K2319/00