公开(公告)号：EP2640419B1

公开(公告)日：2018-12-05

申请号：EP11781825.2

申请日：2011-11-15

申请人： VIB VZW ,  Universiteit Gent

发明人： SAELENS, Xavier ,  SCHEPENS, Bert ,  FIERS, Walter

IPC分类号： A61K39/155 ,  A61P31/12

CPC分类号： A61K39/155 ,  A61K39/12 ,  A61K39/385 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55544 ,  A61K2039/55566 ,  A61K2039/575 ,  A61K2039/6031 ,  A61K2039/6075 ,  A61K2039/6081 ,  A61K2039/645 ,  C07K7/06 ,  C07K14/005 ,  C07K14/78 ,  C07K16/1027 ,  C07K2317/10 ,  C07K2317/76 ,  C12N7/00 ,  C12N7/02 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18571

摘要： Described is a vaccine against Respiratory Syncytial Virus (RSV). More specifically, described is a recombinant subunit vaccine comprising the ectodomain of the RSV-encoded Small Hydrophobic (SH) protein. The ectodomain of SH is referred to as SHe. The ectodomain is typically presented as an oligomer, or a pentamer. Further described are antibodies, raised against the ectodomain or specific for the ectodomain, and their use for protecting a subject against RSV infection and/or for treatment of an infected subject.

公开(公告)号：EP3393512A1

公开(公告)日：2018-10-31

申请号：EP16816405.1

申请日：2016-12-09

申请人： Pfizer Inc.

发明人： CHE, Ye ,  DORMITZER, Philip Ralph ,  GRIBENKO, Alexey Vyacheslavovich ,  HANDKE, Luke David ,  PRASAD, Avvari Krishna ,  QIU, Xiayang ,  RUPPEN, Mark Edward ,  SONG, Xi ,  SWANSON, Kena Anne ,  KODALI, Srinivas ,  XU, Xin ,  EFFEREN, KariAnn Sweeney ,  CAI, Ping ,  TOMPKINS, Kristin Rachael ,  NUNEZ, Lorna Del Pilar

IPC分类号： A61K39/155 ,  A61K39/12 ,  C07K14/005

CPC分类号： A61K39/155 ,  A61K39/12 ,  A61K2039/575 ,  C07K14/005 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/40 ,  C07K2319/70 ,  C07K2319/735 ,  C12N7/00 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18571

摘要： The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.

公开(公告)号：EP3389643A1

公开(公告)日：2018-10-24

申请号：EP16875077.6

申请日：2016-12-10

申请人： Bharat Biotech International Limited ,  Council of Scientific and Industrial Research

发明人： ELLA, Krishna Murthy ,  BRUNDA, Ganneru ,  KUMAR, Halmathur Mahabalarao Sampath ,  SREEKANTH, Miryala

IPC分类号： A61K31/00 ,  A61K39/00 ,  A61K39/39 ,  A61K38/00

CPC分类号： A61K39/39 ,  A61K38/00 ,  A61K2039/5555 ,  A61K2039/57 ,  A61K2039/575 ,  C12N2710/00034

摘要： wherein R1 and R2 both are hydrogen; or R1 is hydrogen and R2 is alkyl or aryl; or R1 is alkyl or aryl and R2 is hydrogen; or R1 and R2 both are alkyl or aryl (same or different groups); wherein alkyl group constitute C1-C6 alkyl or higher (both linear and branched) with or without heteroatoms; and aryl group constitute phenyl, substituted phenyl, heteraryl, arylalkyl and polynuclear aromatics. These compounds possess excellent pharmacological properties, in particular immunomodulating properties for use as adjuvant in vaccine formulations. These compounds are, particularly useful as adjuvants in vaccines.

公开(公告)号：EP3380494A1

公开(公告)日：2018-10-03

申请号：EP16867490.1

申请日：2016-11-24

申请人： The University of Saskatchewan

发明人： GERDTS, Volker ,  ALLAN, Brenda ,  VAN DEN HURK, Jan ,  ZHOU, Yan ,  ZAKHARTCHOUK, Alexander ,  TIKOO, Suresh ,  POTTER, Andrew

IPC分类号： C07K14/165 ,  A61K39/215 ,  A61K39/42 ,  A61P31/14 ,  C07K16/10 ,  C12N7/00 ,  G01N33/564 ,  G01N33/569 ,  G01N33/577

CPC分类号： A61K39/12 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/575 ,  A61P31/12 ,  C07K16/10 ,  C12N2770/20022 ,  C12N2770/20034 ,  G01N33/56983 ,  G01N2333/17

摘要： Immunogens, compositions and methods for treating, preventing and/or diagnosing PEDV infection in pigs are disclosed. The compositions and methods use inactivated or attenuated virus-containing vaccines, or subunit vaccines, including immunogens and mixtures of immunogens derived from PEDV isolates.

公开(公告)号：EP3371316A1

公开(公告)日：2018-09-12

申请号：EP16791573.5

申请日：2016-11-03

申请人： Hookipa Biotech AG

发明人： MONATH, Thomas ,  COHEN, Katherine ,  BAUMGARTL-STRASSER, Vera

IPC分类号： C12N15/86 ,  A61K39/29 ,  C12N15/36 ,  C12N15/62

CPC分类号： C07K14/005 ,  A61K9/0019 ,  A61K39/292 ,  A61K2039/5256 ,  A61K2039/54 ,  A61K2039/575 ,  A61P31/20 ,  C07K2319/00 ,  C12N15/86 ,  C12N2730/10134 ,  C12N2760/10022 ,  C12N2760/10043

摘要： The present application provides immunotherapies for Hepatitis B virus infections. Provided herein are genetically modified arenaviral vectors suitable as vaccines for prevention and treatment of Hepatitis B virus infections. Also provided herein are pharmaceutical compositions and methods for the treatment of Hepatitis B virus infections. Specifically, provided herein are pharmaceutical compositions, vaccines, and methods of treating Hepatitis B virus infection.

公开(公告)号：EP3364981A1

公开(公告)日：2018-08-29

申请号：EP16858393.8

申请日：2016-10-21

申请人： ModernaTX, Inc.

发明人： CIARAMELLA, Giuseppe ,  JOHN, Shinu ,  MOUSAVI, Kambiz

IPC分类号： A61K31/7105 ,  A61K31/7115 ,  A61K39/245 ,  A61P31/22

CPC分类号： A61K39/245 ,  A61K31/7105 ,  A61K31/7115 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/575 ,  C07K14/005 ,  C07K2319/02 ,  C12N7/00 ,  C12N2710/16122 ,  C12N2710/16134 ,  C12N2710/16151 ,  C12N2710/16171

摘要： The disclosure describes HCMV ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：EP2959916B1

公开(公告)日：2018-08-08

申请号：EP15174330.9

申请日：2012-02-14

申请人： Boehringer Ingelheim Vetmedica GmbH

发明人： PESCH, Stefan ,  BURGARD, Kim ,  OHLINGER, Volker ,  ORVEILLON, Francois-Xavier ,  KROLL, Jeremy ,  LAYTON, Sarah ,  PIONTKOWSKI, Michael Dennis ,  ROOF, Michael B. ,  UTLEY, Philip ,  VAUGHN, Eric Martin

IPC分类号： A61K39/12 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61K2039/5254 ,  A61K2039/53 ,  A61K2039/552 ,  A61K2039/575 ,  C12N7/00 ,  C12N2770/10021 ,  C12N2770/10034 ,  C12N2770/10064 ,  C12N2770/10071

摘要： The present invention is related to improved modified live PRRS vaccines containing new PRRSV European strains of PRRSV and methods of use and manufacture of such vaccines.

公开(公告)号：EP3352786A1

公开(公告)日：2018-08-01

申请号：EP16775844.0

申请日：2016-09-23

申请人： The Secretary of State for Health

发明人： VIPOND, Julia ,  BEWLEY, Kevin

IPC分类号： A61K39/02 ,  A61K38/16 ,  C07K14/195

CPC分类号： A61K39/0208 ,  A61K45/06 ,  A61K2039/575 ,  C07K14/195 ,  C07K14/29 ,  C07K16/1203 ,  G01N33/56911

摘要： The present invention provides antigens, for use in the treatment or prevention of C. burnetii infection. Also provided are nucleic acids encoding such antigens, and antibodies raised against such antigens.

公开(公告)号：EP3349786A1

公开(公告)日：2018-07-25

申请号：EP16847498.9

申请日：2016-09-16

申请人： The General Hospital Corporation d/b/a Massachusetts General Hospital

发明人： POZNANSKY, Mark C.

IPC分类号： A61K39/00 ,  A61K38/19 ,  C07K14/52 ,  C07K16/28

CPC分类号： A61K31/395 ,  A61K31/351 ,  A61K31/454 ,  A61K35/15 ,  A61K35/17 ,  A61K39/0011 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/5154 ,  A61K2039/55511 ,  A61K2039/575 ,  A61P35/00 ,  C07K14/52 ,  C07K14/7158 ,  C12N5/0636 ,  C12N5/0645 ,  C12N2501/22 ,  C12N2501/73

摘要： This invention provides ex vivo methods for making modified PBMC compositions having overall anti-fugetactic properties for the effective and efficient treatment of tumors or cancers in a patient, and compositions and use thereof, following treatment with an antigen presenting cell-based vaccine against a cancer antigen.

公开(公告)号：EP3189853A4

公开(公告)日：2018-07-11

申请号：EP15829798

申请日：2015-08-04

申请人： NITTO DENKO CORP

发明人： SHISHIDO TAKUYA ,  ASARI DAISUKE ,  MATSUSHITA KYOHEI ,  HORI MITSUHIKO

IPC分类号： A61K39/39 ,  A61K45/00 ,  A61P37/02 ,  A61P43/00

CPC分类号： A61K39/39 ,  A61K45/00 ,  A61K2039/54 ,  A61K2039/572 ,  A61K2039/575

摘要： The present invention aims to provide a composition for promoting immunity induction and a vaccine pharmaceutical composition which are universally usable for inducing immunity to various antigens and capable of exerting a high immunity inducing effect. The present invention relates to a composition for promoting immunity induction containing at least one nuclear receptor ligand and also relates to a vaccine pharmaceutical composition for inducing immunity containing an antigen and a composition for promoting immunity induction that is at least one nuclear receptor ligand.