公开(公告)号：EP0932663A1

公开(公告)日：1999-08-04

申请号：EP97950599.0

申请日：1997-11-12

申请人： PIONEER HI-BRED INTERNATIONAL, INC.

发明人： DUVICK, Jon ,  ROOD, Tracy, A.

IPC分类号： C12N1 ,  A01N63 ,  A23B9 ,  A23L3 ,  A62D3 ,  C12Q1

CPC分类号： C12R1/01 ,  A01N63/00 ,  A23B9/28 ,  A23L3/3463 ,  C12Q1/04 ,  Y10S435/822 ,  Y10S435/824

摘要： The present invention provides a bacterial microorganism having the ability to degrade or detoxify moniliformin or structurally related mycotoxins. The present invention further provides a method for detoxification or grain pre- or post-harvest using microbes having the ability to degrade or detoxify moniliformin or derivatives or analogs of moniliformin.

公开(公告)号：EP0914150A1

公开(公告)日：1999-05-12

申请号：EP97922639.0

申请日：1997-05-02

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： CONRAD, Patricia, A. ,  BARR, Bradd, C. ,  ANDERSON, Mark, L. ,  SVERLOW, Karen, W. ,  LOUIE, Kitland

IPC分类号： C12N15 ,  A61K31 ,  A61K39 ,  A61P33 ,  C07K14 ,  C12P21 ,  C12Q1 ,  G01N33 ,  A61K38 ,  C12R1

CPC分类号： G01N33/56961 ,  A61K38/00 ,  C07K14/44 ,  C12Q1/6893 ,  G01N2469/20

摘要： The present invention provides isolated bovine Neospora cultures. The cultures are used to develop diagnostic assays for the detection of Neospora infections in cattle and other animals. Also provided are pharmaceutical compositions for the treatment and prevention of Neospora infections.

公开(公告)号：EP0912549A1

公开(公告)日：1999-05-06

申请号：EP97934849.0

申请日：1997-06-20

申请人： BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM

发明人： KERWIN, Sean ,  HURLEY, Laurence, H. ,  DeLUCA, Mark, R. ,  MOORE, Bob, M., III ,  MUNDY, Gregory

IPC分类号： C07D401 ,  A61K31 ,  C07D215 ,  C07D277 ,  C07D417

CPC分类号： C07D215/38 ,  A61K31/428 ,  A61K31/47 ,  C07D277/82

摘要： The present invention relates to pharmacologically active compounds which are capable of binding to nuclear hormone receptors and are useful for the stimulation of osteoblast proliferation and ultimately bone growth. This invention also relates to the use of such compounds for the treatment or prevention of diseases and/or disorders associated with nuclear hormone receptor families.

公开(公告)号：EP0912198A1

公开(公告)日：1999-05-06

申请号：EP97917769.0

申请日：1997-04-01

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： BENZ, Christopher, C. ,  PAPAHADJOPOULOS, Demetrois ,  PARK, John, W. ,  HONG, Keelung ,  KIRPOTIN, Dmitri

IPC分类号： A61K9 ,  A61K31 ,  A61K33 ,  A61K38 ,  A61K39 ,  A61K47 ,  A61K49 ,  A61P35 ,  A61P37 ,  A61P43 ,  C07K16 ,  C07K17

CPC分类号： C07K16/32 ,  A61K9/127 ,  A61K9/1271 ,  A61K38/00 ,  A61K47/6849 ,  A61K47/6913 ,  B82Y5/00 ,  C07K16/2863 ,  C07K2317/77

摘要： The present invention provides for immunoliposomes that optimizes internalization of a drug into target cells bearing a characteristic cell surface marker. The immunoliposomes comprise a Fab' domain of an antibody that specifically binds the characteristic marker, an amphipathic vesicle-forming lipid, and a polyethylene glycol derivatized lipid. The invention also provides for growth-inhibiting immunoliposomes that lack growth-inhibiting therapeutic agents and yet are capable of inhibiting the growth and proliferation of target cells.

公开(公告)号：EP0885461A1

公开(公告)日：1998-12-23

申请号：EP97907994.0

申请日：1997-03-03

申请人： UNIAX CORPORATION

发明人： PEI, Qibing ,  YU, Gang ,  YANG, Yang

IPC分类号： C08G61 ,  C09K11 ,  H01L51

CPC分类号： H01L51/5012 ,  C08G61/00 ,  C08G61/10 ,  C09K11/06 ,  H01L51/0039 ,  H01L51/42 ,  H01L51/5032 ,  Y10S428/917

摘要： Fluorenes and polyfluorenes having one or two polar-group-containing alkyl substituents on their '9' carbon methylenes are disclosed together with the polymers' use as luminescent materials in organic light-emitting diodes and light-emitting electrochemical cells.

公开(公告)号：EP0862585A1

公开(公告)日：1998-09-09

申请号：EP93924307.0

申请日：1993-10-08

申请人： GLYCOMED INCORPORATED

发明人： HOLME, Kevin, Ross ,  SHAKLEE, Patrick, Neil ,  TYRRELL, David, John

IPC分类号： A61K31 ,  C08B37

CPC分类号： A61K31/715 ,  A61K31/727 ,  C08B37/0075

摘要： Methods of making and using, as prophylatics or therapeutics for preventing or treating certain diseases including cancer, O-desulfated heparin compositions, preferably 2-O, 3-O desulfated heparin compositions, wherein the methods permit regulating the degree of 2-O, 3-O desulfation to produce compositions that are variably desulfated including about 99 % and 75 % desulfated at the 2-O and 3-O positions, respectively.

公开(公告)号：EP0845001A1

公开(公告)日：1998-06-03

申请号：EP96928176.0

申请日：1996-08-16

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： TOWNSEND, Leroy, B. ,  DRACH, John, C.

IPC分类号： C07H19 ,  A61K31 ,  A61P31

CPC分类号： C07H19/052

摘要： The present invention relates to polysubstituted benzimidazoles, having formula (I), wherein Q is substituted benzimidazole group attached at the benzimidazole 1-position; R is a halogen or atomic number 9 to 53, inclusive (i.e., -F, -Cl, -Br, or -I); azido (i.e., -N3); or -X-R1, wherein X is a chalcogen of atomic number 8 to 16, inclusive (i.e., -O- or -S-), and R1 may be straight or branched chain alkyl of 1 to 8 carbon atoms; and R2 and R3 may be the same or different and are separately -O-C(=O)CH3 (i.e., -OAc) or hydroxy (i.e., -OH); and pharmaceutically acceptable salts and operative combinations thereof. Also provided by this invention are compositions comprising a polysubstituted benzimidazoles as defined above and methods of use thereof.

公开(公告)号：EP0835451A1

公开(公告)日：1998-04-15

申请号：EP96917616.0

申请日：1996-06-27

申请人： Chiron Diagnostics Corporation

发明人： BARLOW, Eve, H. ,  CARROLL, Eddie, III ,  CONNOLLY, Joseph, E. ,  LEE, Michael, J. ,  MARTINELLI, Richard, A. ,  UNGER, John, T.

IPC分类号： G01N33

CPC分类号： G01N33/542 ,  G01N33/582

摘要： The assay described herein is predicated on an observation that when acridinium ester labeled tracers are bound to their corresponding binding conjugate immobilized on a metal oxide solid phase, the measurable chemiluminescent light emission of the labeled tracer bound to the solid phase is quenched as compared to the free fraction tracer that is unattached to the solid phase. According to the invention, a non-separation specific binding assay to detect or quantify the presence of an analyte is provided where the entire reaction mixture is flashed (including unreacted tracer) and modulated signal (because of the quench effect) is associated with a reference, thus determining the amount or presence of said analyte in said sample. Disadvantages inherent in heterogeneous assays employing multiple separations may be avoided using this non-separation method.

公开(公告)号：EP0835438A1

公开(公告)日：1998-04-15

申请号：EP96917615.0

申请日：1996-06-27

申请人： Chiron Diagnostics Corporation

发明人： SCHARLACK, Ronald, S. ,  SODICKSON, Lester

IPC分类号： G01N21

CPC分类号： G01N21/274

摘要： The present invention provides apparatus and methods for determining the concentration of sample components of a sample by an analytical technique that yields a spectrum that can be written as Y(φ) = P(φ) . C. The apparatus and methods of the invention account for experimental errors that give rise to distortions in the observed spectrum and that consequently result in inaccurate determinations of sample component concentrations. The invention accounts for such errors by modeling the total experimental error as the sum of one or more types of errors that can be written as κ . K. The spectrum is then modeled as Y = P . C + κ . K. Using the observed spectrum, known values for P, and a mathematical model for κ, this equation can be solved for the best fit value of the sample component concentrations, C, and the magnitudes of the errors, K. The method can be used for any error that can be modeled in the foregoing manner, such as a shift in the spectrum. Particular types of shift include constant shift as well as linear shift across the entire spectrum. The apparatus and methods are advantageously used in absorbance spectroscopy and chromatography.

公开(公告)号：EP0829068A1

公开(公告)日：1998-03-18

申请号：EP96916909.0

申请日：1996-05-30

申请人： MOLECULAR BIOSYSTEMS, INC.

发明人： LEVENE, Harold

IPC分类号： A61B6 ,  A61B5 ,  A61B8 ,  G06K9 ,  G06T1 ,  G06T5

CPC分类号： G06K9/38 ,  G06T7/12 ,  G06T2207/10132 ,  G06T2207/20104 ,  G06T2207/30048

摘要： The present invention is a novel system and method for automatically identifying borders of regions of interest within an image of a patient's organ or tissue. The system generates images - before, during and after the administration of a contrast agent. Once the set of images have been taken, the system begins automatic processing of the images. The steps of the processing include the identification of baseline image frames, identification of baseline intensities for each given pixel in the ROI, baseline subtraction on a per-pixel basis, determining a probability of signal-to-noise ratio for each pixel, and thresholding each pixel to determine if a pixel belongs to an area inside the border region or an area outside the border region. To exactly determine which pixels that are at the border, the method refines the set by locally minimizing a total cost function that relates a low value to points typically found on a contrast enhanced image. The border of the region of interest is thereby determined.

摘要翻译： 本发明是用于自动识别患者器官或组织的图像内的感兴趣区域的边界的新型系统和方法。 系统会在造影剂给药前，给药期间和之后生成图像。 一旦拍摄了一组图像，系统开始图像的自动处理。 处理的步骤包括基线图像帧的识别，ROI中每个给定像素的基线强度的识别，基于每个像素的基线减法，确定每个像素的信噪比的概率，以及阈值 每个像素以确定像素是否属于边界区域内的区域或边界区域外的区域。 为了精确确定边界中的哪些像素，该方法通过局部最小化总成本函数来优化集合，该总成本函数将低值与通常在对比度增强图像上发现的点相关联。 由此确定感兴趣区域的边界。