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    VASCULAR MARKERS IN THE REMODELLING OF CARDIAC INJURY
    5.
    发明公开
    VASCULAR MARKERS IN THE REMODELLING OF CARDIAC INJURY 审中-公开
    血管标志心力衰竭重组

    公开(公告)号：EP2198310A1

    公开(公告)日：2010-06-23

    申请号：EP08804007.6

    申请日：2008-09-11

    申请人： Roche Diagnostics GmbH ,  F. Hoffmann-La Roche AG

    发明人： HESS, Georg ,  HORSCH, Andrea ,  ZDUNEK, Dietmar

    IPC分类号： G01N33/96

    CPC分类号： G01N33/6893 ,  G01N2333/71 ,  G01N2800/324

    摘要： The present invention is concerned with diagnostic means and methods. More specifically, the present invention relates to a method for diagnosing the angiogenic status of a subject suffering from myocardial infarction comprising determining the amounts of PLGF, sFLT1 and Endoglin in a first sample of a subject obtained after myocardial infarction and in a second sample of the said subject obtained after the said first sample and comparing the said amounts in the first sample with those in the second sample whereby the angiogenic status is diagnosed. The present invention also encompasses a method of determining whether a subject suffering from myocardial infarction is susceptible to a pro-angiogenic therapy. Finally, the present invention relates to a kit or a device for carrying outthe method of the invention.

    Insektenschutzmittel für natürliche Fasermaterialien
    7.
    发明公开
    Insektenschutzmittel für natürliche Fasermaterialien 有权
    具有驱虫剂处理的天然纤维材料，程序和使用

    公开(公告)号：EP2108733A1

    公开(公告)日：2009-10-14

    申请号：EP08154201.1

    申请日：2008-04-08

    申请人： THOR GmbH

    发明人： Butz, Volker ,  Erm, Harald

    IPC分类号： D06M11/17 ,  D06M11/20 ,  D06M16/00 ,  A01N59/10 ,  A01N59/14

    CPC分类号： D06M11/20 ,  A01N59/10 ,  A01N59/14 ,  A01N59/16 ,  D06M11/17 ,  D06M16/006 ,  D06M2101/02 ,  D06M2101/04 ,  D06M2101/06 ,  D06M2101/10 ,  D06M2101/12 ,  D06M2101/14

    摘要： Die vorliegende Erfindung betrifft Mittel zum Schutz von natürlichen Fasermaterialien wie Proteinfasermaterial, insbesondere Wolle, Seide, Pelze und Federn sowie Zellulosefasermaterialien, insbesondere Flachs, gegen den Befall durch Schädlinge, wie Motten- und Käferlarven. Ebenfalls betrifft die Erfindung ein Verfahren zum Schutz dieser Materialien gegenüber diesen Schädlingen, indem das zu schützende Material mit dem erfindungsgemäßen Mittel behandelt wird. Ein weiterer Gegenstand der vorliegenden Erfindung ist das mit dem erfindungsgemäßen Mittel ausgerüstete Material selbst.

    摘要翻译： 提供了天然纤维材料与对害虫侵袭和损害的精加工包括用钾或钠hexafluorotitanates，六氟或四氟硼酸盐的材料。 提供了天然纤维材料与对害虫侵袭和损害的精加工包括与钾或钠hexafluorotitanates，六氟锆酸盐或四氟硼酸盐（K 2TiF 6，钠2TiF 6，K 2ZrF 6，钠2ZrF 6，KBF器40r的NaBF 4）处理该材料。 因此独立权利要求中包括了：（1）用如上述的精加工天然纤维材料; （2）产品用于保护天然纤维材料从病虫害侵袭和损害，包括K个2TiF 6，钠2TiF 6，K 2ZrF 6，钠2ZrF 6，CBF器40r的NaBF 4，活动：杀虫剂。 作用机理：没有给出。

    VERFAHREN ZUR HERSTELLUNG VON 1-BUTEN
    8.
    发明授权
    VERFAHREN ZUR HERSTELLUNG VON 1-BUTEN 有权
    用于生产1-丁烯

    公开(公告)号：EP1682468B1

    公开(公告)日：2009-07-15

    申请号：EP04790913.0

    申请日：2004-10-27

    申请人： BASF SE

    发明人： SCHINDLER, Götz-Peter ,  BRODHAGEN, Andreas ,  JOHANN, Thorsten ,  HILL, Thomas ,  SIGL, Marcus ,  BENFER, Regina

    IPC分类号： C07C5/333 ,  C07C5/25 ,  C07C5/05 ,  C07C7/08

    CPC分类号： C07C5/333 ,  C07C5/05 ,  C07C5/2506 ,  C07C7/08 ,  C07C11/08

    摘要： The invention relates to a method for producing 1-butene by feeding an n-butane containing feed gas flow (a) to a dehydration zone and dehydrating the n-butane, thereby obtaining a product gas flow (b); removing hydrogen and low-boiling secondary constituents, thereby obtaining a C4 product gas flow (c); separating the C4 product gas flow (c) into an n-butane containing return flow and a 1-butene, 2-butene and butadiene containing flow (d2) by extractive distillation and returning the return flow to the dehydration zone; feeding the flow (d2) to a selective hydration zone and selectively hydrating butadiene to give 1-butene and/or 2-butene, thereby obtaining a 1-butene and 2-butene containing flow (4); feeding the flow (e) and a 1-butene and 2-butene containing circular flow to a distillation zone and removing a 1-butene containing value product flow, thereby leaving a 2-butene containing flow (f2); feeding the flow (f2) to an isomerization zone and isomerizing 2-butene to give 1-butene, thereby obtaining the circular flow, and returning the same to the distillation zone.

    METHODS FOR THE IDENTIFICATION OF LRRK2 INTERACTING MOLECULES AND FOR THE PURIFICATION OF LRRK2
    10.
    发明授权
    METHODS FOR THE IDENTIFICATION OF LRRK2 INTERACTING MOLECULES AND FOR THE PURIFICATION OF LRRK2 有权
    用于鉴定LRRK2相互作用的分子以及用于清洁LRRK2

    公开(公告)号：EP1866433B1

    公开(公告)日：2009-05-13

    申请号：EP07717962.0

    申请日：2007-03-13

    申请人： CELLZOME AG

    发明人： DREWES, Gerard ,  HOPF, Carsten ,  READER, Valerie

    IPC分类号： C12Q1/48 ,  G01N33/68 ,  C12N9/12

    CPC分类号： C12Q1/485 ,  G01N2800/2835

    摘要： The invention provides in a first aspect a method for the identification of an LRRK2 interacting compound, comprising the steps of providing a protein preparation containing LRRK2, contacting the protein preparation with indol ligand 91 immobilized on a solid support under conditions allowing the formation of an indol ligand 91-LRRK2 complex, incubating the indol ligand 91-LRRK2 complex with a given compound, and determining whether the compound is able to separate LRRK2 from the immobilized indol ligand 91. Furthermore, the invention relates to a method for the identification of an LRRK2 interacting compound, comprising the steps of providing a protein preparation containing LRRK2, contacting the protein preparation with indol ligand 91 immobilized on a solid support and with a given compound under conditions allowing the formation of an indol ligand 91-LRRK2 complex, and detecting the indol ligand 91-LRRK2 complex. Additionally, the invention provides a method for the identification of an LRRK2 interacting compound, comprising the steps of providing two aliquots of a protein preparation containing LRRK2, contacting one aliquot with indol ligand 91 immobilized on a solid support under conditions allowing the formation of an indol ligand 91-LRRK2 complex, contacting the other aliquot with indol ligand 91 immobilized on a solid support and with a given compound under conditions allowing the formation of an indol ligand 91- LRRK2 complex, and determining the amount of indol ligand 91-LRRK2 complex. Furthermore, the invention relates to a method for the purification of LRRK2, comprising the steps of providing a protein preparation containing LRRK2, contacting the protein preparation with indol ligand 91 immobilized on a solid support under conditions allowing the formation of an indol ligand 91-LRRK2 complex, and separating LRRK2 from the immobilized indol ligand 91.