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1.发明公开DIHYDRATE DU (2R,3S)-3-TERT-BUTOXYCARBONYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE DE 4,10$g(b)-DIACETOXY-2$g(a)-BENZOYLOXY-5$g(b),20-EPOXY-1-HYDROXY-9-OXO-19-NOR-CYCLOPROPA G]TAX-11-ENE-13$g(a)-YLE, ET SON PROCEDE DE PREPARATION 失效二水合物（2R，3S）-3-叔丁氧羰基-2-羟基-3-苯基丙酸BETA-4,10-二乙酰氧基2ALFA苯甲酰氧基5beta，20-环氧基-1-羟基-9-氧代 - 19酯 -NOR环丙G] TAX-11-CN-13ALFA基及其制造方法
公开(公告)号：EP0876361A1
公开(公告)日：1998-11-11
申请号：EP96941720.0
申请日：1996-12-09
CPC分类号： C07D305/14
摘要： A 4,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-9-oxo-19-nor-cyclopropa[g]tax-11-ene-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate dihydrate, and the preparation thereof by crystallisation from a water-alcohol or water-ketone solution, are disclosed.
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公开(公告)号：EP0817845A1
公开(公告)日：1998-01-14
申请号：EP96911000.0
申请日：1996-03-29
IPC分类号： C12N15 , A61K35 , A61K38 , A61K48 , A61P31 , A61P43 , C07K7 , C07K14 , C07K16 , C12P21 , C12R1
CPC分类号： C12N15/86 , C07K14/82 , C07K16/18 , C07K2319/00 , C12N15/1034 , C12N15/62 , C12N15/635 , C12N15/85 , C12N2710/10343 , C12N2740/13043 , C12N2830/003
摘要： A novel conditional gene expression system particularly using the creation and expression of bispecific chimeric molecules including a domain capable of selectively binding a given DNA sequence and a sensing domain capable of specifically binding a transactivator or transrepressor or a transactivator or transrepressor complex.
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3.发明公开
公开(公告)号：EP0764156A1
公开(公告)日：1997-03-26
申请号：EP95922572.0
申请日：1995-06-07
发明人： BOUCHARD, Hervé , BOURZAT, Jean-Dominique , COMMER ON, Alain , TERRIER, Corinne , ZUCCO, Martine
CPC分类号： C07D407/12 , C07D305/14 , C07D409/12 , C07D417/12
摘要： New taxoids having general formula (I), (II), preparation thereof and pharmaceutical compositions containing them. In general formula (I), Ra is hydrogen, hydroxy, alkoxy, acyloxy, alkoxyacetoxy and Rb is hydrogen or Ra and Rb form together with the carbon atom to which they are linked a ketone function; Z is a hydrogen atom or a radical having general formula (II) wherein R1 is an optionally substituted benzoyl radical, thenoyl or furoyl or a radical R2-O-CO- wherein R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted phenyl or heterocyclyl radical; R3 is an alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, naphtyl or heterocyclic aromatic radical, and R4 and R5, which are the same or different, represent an alkyl, alkenyl, alkynyl, cycoalkyl, cycloalkenyl, bicycloalkyl, aryl, or heterocyclyl radical, R5 not representing a methyl radical. The new products having general formula (I) wherein Z is a radical of general formula (II) have remarkable antitumoral and antileukaemic properties.
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4.发明公开
公开(公告)号：EP0764154A1
公开(公告)日：1997-03-26
申请号：EP95922569.0
申请日：1995-06-07
发明人： BOUCHARD, Hervé , BOURZAT, Jean-Dominique , COMMERCON, Alain , TERRIER, Corinne , ZUCCO, Martine
CPC分类号： C07D305/14
摘要： New taxoids having general formula (I), (II) preparation thereof and pharmaceutical compositions containing them. In general formula (I): Ra is hydrogen, hydroxy, alkoxy, acyloxy, alkoxyacetoxy, and Rb is hydrogen or Ra and Rb form together with the carbon atom to which they are linked a ketone function, Z is a hydrogen atom or a radical having general formula (II) wherein R1 is an optionally substituted benzoyl radical, a thenyl or furoyl radical or a radical R2-O-CO- wherein R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted phenyl or heterocyclyl radical; R3 is an alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, naphtyl or heterocyclic aromatic radical, and R4 and R5, similar or different, represent an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, aryl or heterocyclyl radical, with the condition that R5 does not represent a methyl radical. The new products having general formula (I) wherein Z is a radical having general formula (II) have remarkable antitumoral and antileukaemic properties.
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公开(公告)号：EP0593656A1
公开(公告)日：1994-04-27
申请号：EP92915686.0
申请日：1992-07-03
CPC分类号： A61K31/335 , A61K9/0019 , A61K9/0043 , A61K9/08 , A61K47/10 , A61K47/26 , A61K47/44
摘要： La présente invention concerne de nouvelles compositions à base de dérivés de la classe des taxanes constituées de solutions de ces dérivés dans un mélange de solvant composé d'éthanol et de polysorbate. Ces solutions sont utilisées pour préparer des perfusions.
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公开(公告)号：EP0532705A1
公开(公告)日：1993-03-24
申请号：EP91915103.0
申请日：1991-05-24
IPC分类号： A61K31 , A61P29 , A61P37 , C07D401 , C07D405 , C07D409 , C07D411 , C07D413 , C07D417 , C07D419
CPC分类号： C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： On décrit certains composés quinoléinyle-benzohétérobicycliques et leur utilisation comme agents pharmaceutiques précieux, notamment comme inhibiteurs de lipoxygénase et/ou comme antagonistes de leucotriène et/ou comme inhibiteurs de la libération de médiateurs, les composés étant utiles en tant qu'agents anti-inflammatoires et anti-allergiques.
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公开(公告)号：EP0520983A1
公开(公告)日：1993-01-07
申请号：EP90905311.0
申请日：1990-03-15
发明人： PURKAYSTHA, Abdur, R. , GAZDICK, Gary, G. , DORRELL, Jay, E. , MOZZONE, Keith, C. , LEVIN, Howard, J.
摘要： L'invention concerne des présentations de médicaments à usage rectal ou vaginal, comprenant de la calcitonine et du monoglycéride d'acide caprylique dans un support pharmaceutiquement acceptable du type suppositoire.
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8.发明公开QUINOLINYL-BENZOPYRAN DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? 失效喹啉BENZOPYRANABKÖMMLINE拮抗剂白三烯D4的。
公开(公告)号：EP0434827A1
公开(公告)日：1991-07-03
申请号：EP90912046.0
申请日：1990-07-09
CPC分类号： C07D405/12 , C07D405/14
摘要： Cette invention concerne certains composés de quinolinyl-benzopyrane et leur utilisation en tant qu'agents pharmaceutiques efficaces, en particulier comme inhibiteurs de la lipoxygénase et/ou comme antagonistes de leukotriène et/ou comme inhibiteurs de la libération de médiateurs et ont des propriétés anti-inflammatoires et anti-allergiques.
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公开(公告)号：EP0843814A1
公开(公告)日：1998-05-27
申请号：EP96928485.0
申请日：1996-08-07
发明人： WILLIAMS, Peter
CPC分类号： G01N33/02 , G01N21/3563 , G01N21/359
摘要： A method for determining in vivo the nutritional value of animal feed during the transit of the feed in the digestive system of ruminants, comprising analysing said feed, more particularly ensilage, by near infrared spectrophotometry.
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公开(公告)号：EP0812205A1
公开(公告)日：1997-12-17
申请号：EP95900403.0
申请日：1994-10-17
CPC分类号： C07K5/06113 , A61K38/00 , C07K5/021 , C07K5/0806
摘要： The present invention relates to azacycloalkylalkanoyl peptides and pseudopeptides which inhibit platelet aggregation and thrombus formation thereby being useful in the prevention and treatment of thrombosis associated with disease states such as myocardial infarction, stroke, peripheral arterial disease, and disseminated intravascular coagulation, to methods for the prevention or treatment of thrombosis in a mammal in need of such therapy comprising the administration of a therapeutically effective amount of such compounds, and to pharmaceutical compositions comprising such compounds.
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