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    PREPARATION METHOD FOR OXETANE-2-METHYLAMINE
    5.
    发明公开
    PREPARATION METHOD FOR OXETANE-2-METHYLAMINE 审中-公开

    公开(公告)号：EP4194446A1

    公开(公告)日：2023-06-14

    申请号：EP21847921.0

    申请日：2021-11-12

    申请人： ACCELA CHEMBIO CO., LTD.

    发明人： TIAN, Yong ,  YANG, Jun ,  XUE, Duoqing ,  WU, Yong ,  CHEN, Lihuang

    IPC分类号： C07D305/06 ,  C07D211/40

    摘要： Disclosed is a method for preparing oxetan-2-ylmethanamine, which belongs to the field of organic synthesis. [2-(1-ethoxyethoxy)methyl]propylene oxide is used as an initial raw material, and reacted in the presence of potassium tert-butoxide and trimethylsulfoxonium iodide; the resulting product is reacted with a sulfonyl compound and triethylamine; the resulting product is reacted with a compound of phthalimide; the resulting product is reacted with an amino group-containing compound, to obtain oxetan-2-ylmethanamine. The method according to the disclosure allows for an overall yield of not less than 30% in scale-up production (kilogram level), which is higher. Moreover, compared with the traditional method for preparing oxetan-2-ylmethanamine, a palladium-carbon catalytic hydrogenation step is not required, and dangerous chemical-sodium azide is not required in the method according to the disclosure. Thus, the method has high safety, low production cost, simple operations, and thereby is suitable for industrial production.

    METHOD FOR SYNTHESIZING OXETANE COMPOUND BY MICROREACTOR
    7.
    发明公开
    METHOD FOR SYNTHESIZING OXETANE COMPOUND BY MICROREACTOR 审中-公开

    公开(公告)号：EP4129991A1

    公开(公告)日：2023-02-08

    申请号：EP21782226.1

    申请日：2021-03-16

    申请人： Changzhou Tronly Advanced Electronic Materials Co., Ltd. ,  Changzhou Tronly New Electronic Materials Co., Ltd

    发明人： QIAN, Xiaochun

    IPC分类号： C07D305/06

    摘要： The present invention provides a method for synthesizing an oxetane compound by a microreactor. The synthesis method comprises: introducing trimethylolpropane and carbonate into the microreactor in the presence of an alkaline catalyst, and synthesizing the oxetane compound by means of a micro-reaction continuous flow process under an inert solvent or a solvent-free condition. Compared with conventional reactors, the microreactor has the advantages of being high in heat transfer mass transfer coefficient, good in mixing performance, easy to control in temperature, safe and controllable in process and the like. The three oxetane products are produced by utilizing the advantages of the microreactor, thereby greatly improving the mass transfer heat transfer performance of a reaction system, shortening the reaction time, improving the production efficiency, particularly avoiding the long-time high-temperature process in the pyrolysis process, reducing the production of high-boiling-point by-products, improving the yield, realizing continuity and automation of the process, and improving process safety. The reaction device required in the synthesis process is small in size and high in safety, and occupies a small area in a production site.