公开(公告)号：EP2447252B1

公开(公告)日：2020-01-15

申请号：EP11180106.4

申请日：2005-05-23

申请人： HMI Medical Innovations, LLC.

发明人： HOUSEY, Gerard M.

IPC分类号： C07D213/81 ,  C07D213/87 ,  C07D215/50 ,  C07D231/14 ,  C07D239/42 ,  C07D239/48 ,  C07D239/84 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D253/065

公开(公告)号：EP3052518B1

公开(公告)日：2020-01-08

申请号：EP14851250.2

申请日：2014-10-03

申请人： Beth Israel Deaconess Medical Center, Inc.

发明人： BAROUCH, Dan, H. ,  BRICAULT, Christine

IPC分类号： C07K14/16

公开(公告)号：EP3579739A1

公开(公告)日：2019-12-18

申请号：EP18750608.4

申请日：2018-02-08

申请人： Scanoptix, Inc.

发明人： DIRGHANGI, Arjun ,  METRO, Gopal ,  WILLIAMS, Dustin ,  BABU, Varundev ,  LAGALANTE, Daniel ,  IRIS, Jeffrey

IPC分类号： A61B3/12

公开(公告)号：EP3571564A1

公开(公告)日：2019-11-27

申请号：EP18742215.9

申请日：2018-01-18

申请人： Coulomb Inc.

发明人： BAZHINOV, Alexander

IPC分类号： G05D17/00 ,  G05D3/12 ,  G05D9/00 ,  G05D5/00

公开(公告)号：EP3444362A3

公开(公告)日：2019-06-26

申请号：EP18188388.5

申请日：2014-05-02

申请人： Ruprecht-Karls-Universität Heidelberg ,  Deutsches Krebsforschungszentrum

发明人： Burwinkel, Barbara ,  Madhavan, Dharanija

IPC分类号： C12Q1/6886

摘要： Provided is a novel method for the early detection and/or discrimination of cancer and anticancer agents for the prevention or early treatment of cancer. In particular, the method relates to the determination of levels of circulating miRNAs in breast cancer patients, both primary and metastatic. Furthermore, kits, devices, pharmaceutical compositions as well as methods related thereto are described.

公开(公告)号：EP3444362A2

公开(公告)日：2019-02-20

申请号：EP18188388.5

申请日：2014-05-02

申请人： Ruprecht-Karls-Universität Heidelberg ,  Deutsches Krebsforschungszentrum

发明人： Burwinkel, Barbara ,  Madhavan, Dharanija

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  A61N5/10 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178

摘要： Provided is a novel method for the early detection and/or discrimination of cancer and anticancer agents for the prevention or early treatment of cancer. In particular, the method relates to the determination of levels of circulating miRNAs in breast cancer patients, both primary and metastatic. Furthermore, kits, devices, pharmaceutical compositions as well as methods related thereto are described.

公开(公告)号：EP3358291A1

公开(公告)日：2018-08-08

申请号：EP16851030.3

申请日：2016-09-05

申请人： Melexis Technologies NV ,  K. K. Melexis Japan Technical Research Center

发明人： YOSHIYA, Takumi

IPC分类号： G01B7/00

CPC分类号： G01D5/145 ,  F16H9/08 ,  F16H59/68 ,  F16H61/662 ,  G01B7/00

摘要： To provide a displacement detection device and a continuously variable transmission device that directly detect the position of the movable sheave.
A displacement detection device includes a magnet 62 that forms a magnetic field, a movable sheave 21 that is rotated in a rotational direction and displaced in a direction perpendicular to the rotational direction and that is a measuring object having a concave portion 210 (or a protrusion) on the circumferential surface, and a sensor 60 disposed between the magnet 62 and the circumferential surface of the movable sheave 21 and detecting a change in magnetic flux density due to the displacement of the movable sheave 21 in the magnetic field formed by the magnet 62 and induced to the concave portion 210 (or the protrusion) .

公开(公告)号：EP2797556B1

公开(公告)日：2018-08-01

申请号：EP13861484.7

申请日：2013-03-01

申请人： Cormatrix Cardiovascular, Inc.

发明人： MATHENY, Robert G.

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2436 ,  A61F2220/0016 ,  A61F2230/0095

摘要： Anchored cardiovascular valves having a support member with at least one leaflet formed therein that is sized and configured to selectively restrict regurgitating blood through the valve, and at least one anchoring mechanism. In a preferred embodiment of the invention, the anchored valves have two anchoring mechanisms, i.e. proximal and distal anchoring mechanisms

公开(公告)号：EP1914298B1

公开(公告)日：2017-12-06

申请号：EP06766452.4

申请日：2006-06-05

申请人： Amano Enzyme Inc.

发明人： AMANO, Hitoshi Gifu R&D Center, Amano EnzymeInc. ,  YAMAGUCHI, S. Gifu R&D Center, Amano Enzyme Inc.

IPC分类号： C12C5/00 ,  C12C7/04

CPC分类号： C12C5/004 ,  C12C7/04

摘要： Disclosed is a process for producing a beer or beer-like beverage having mellowness, a special flavor and a good taste. The beer or beer-like beverage can be produced by allowing a protein deamidase to act on at least a part of a raw material during the production process.

公开(公告)号：EP2044197B1

公开(公告)日：2017-11-22

申请号：EP07784668.1

申请日：2007-07-23

申请人： The University Of Queensland

发明人： NIELSEN, Lars Keld ,  PALFREYMAN, Emma Louise ,  TIMMINS, Nicholas Eion

IPC分类号： C12N5/0787 ,  A61K35/14 ,  A61P37/00

CPC分类号： C12N5/0642 ,  A61K2035/124 ,  C12N2500/02 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/22

摘要： A method is provided for producing a population of post-mitotic cells of the neutrophil lineage, which method comprises the ex vivo steps of: (a) providing a population of cells comprising neutrophil progenitor cells; and (b) culturing the population of cells in an animal cell culture medium comprising (i) one or more early acting cytokines and (ii) one or more cytokines that differentiate said progenitor cells into a neutrophil specific lineage, under conditions of low oxidative stress, the culture medium being agitated when the cells are at a cell density at which oxygen transfer via the surface of the culture medium is insufficient for growth of the progenitor cells and the progeny thereof under static conditions, to produce a population of post-mitotic cells of the neutrophil lineage. The resulting population of cells can be used to increase the number of neutrophils in a patient.