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公开(公告)号：EP2654714B1
公开(公告)日：2018-07-25
申请号：EP11806039.1
申请日：2011-12-09
发明人： MATHENY, Robert G.
IPC分类号： A61K31/351 , A61K31/435 , A61K9/00
CPC分类号： A61K9/0024 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/4418 , A61K31/47 , A61K31/505 , A61K45/06 , A61L17/005 , A61L24/0015 , A61L29/16 , A61L31/16 , A61L2300/434
摘要： A polymeric matrix for delivery of an HMG CoA reductase inhibitor such as a statin to tissue such as cardiac tissue in need thereof for the treatment or prevention of a disease or defect such as atrial fibrillation has been developed. In the preferred embodiment, a statin is delivered by means of a patch sutured to cardiac tissue at the time of cardiothoracic surgery. In the most preferred embodiment, the patch is a biodegradable material providing controlled or sustained release over a prolonged period of time, such as a week. Suitable materials include extracellular matrix, or other biodegradable hydrogels or polymeric materials providing sustained or controlled release of statin at the site of application.
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公开(公告)号：EP2809264A1
公开(公告)日：2014-12-10
申请号：EP13861485.4
申请日：2013-03-01
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2/2412 , A61F2/2475 , A61F2250/0063 , A61L27/362 , A61L27/3625 , A61L27/3629 , A61L27/3633 , A61L27/54 , A61L2430/20
摘要： A two-piece prosthetic valve having first and second members, a first end of the first member being sized and configured to receive a second end of the second member therein, the second end of the second member being attached to the first member at at least one commissure connection point to form at least one leaflet therein.
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3.发明公开STERILIZED, ACELLULAR EXTRACELLULAR MATRIX COMPOSITIONS AND METHODS OF MAKING THEREOF 审中-公开消毒的无细胞/组织细胞外基质成分和方法FOR THEIR
公开(公告)号：EP2714099A1
公开(公告)日：2014-04-09
申请号：EP12792089.0
申请日：2012-05-24
发明人： MATHENY, Robert G.
CPC分类号： A61F2/2412 , A61F2/24 , A61F2/2415 , A61L2/0094 , A61L27/3633 , A61L27/3687 , A61L27/3691 , A61L27/3873 , A61L27/3882 , A61L27/54 , A61L2430/20 , A61L2430/40
摘要： Methods for sterilizing and decellularizing extracellular matrix materials are disclosed. Extracellular matrix compositions produced using the disclosed methods are also disclosed.
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公开(公告)号：EP4176841A1
公开(公告)日：2023-05-10
申请号：EP22200948.2
申请日：2014-03-29
发明人： MATHENY, Robert G.
IPC分类号： A61F2/24
摘要： A prosthetic atrioventricular tissue valve comprising a continuous tubular member formed from a first biocompatible material, the tubular member having proximal and distal ends, and at least one valve leaflet formed therein, the distal end of the tubular member including cardiovascular structure engagement means for connecting the tubular member to a cardiovascular structure, the cardiovascular structure engagement means comprising a plurality of elongated members that extend distally from the distal end of the tubular member.
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公开(公告)号：EP2991582A1
公开(公告)日：2016-03-09
申请号：EP14791562.3
申请日：2014-04-29
发明人： MATHENY, Robert G. , FALLON, Anna
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2210/0004 , A61L27/06 , A61L27/3633 , A61L27/507 , A61L27/54 , A61L27/58 , A61L2300/204 , A61L2300/414 , A61L2300/434 , A61L2430/20
摘要： A prosthetic atrioventricular valve that includes a continuous tubular- member having proximal and distal ends, the tubular- member comprising an extracellular matrix (ECM) material, and a reinforcement member disposed in the tubular member lumen and attached to the distal end of the tubular member, the reinforcement member comprising at least two elongated linear members that are configured to connect the joined tubular and reinforcement members to a cardiovascular structure.
摘要翻译： 一种假体房室瓣膜，其包括具有近端和远端的连续管状构件，所述管状构件包括细胞外基质（ECM）材料以及设置在所述管状构件内腔中并附接到所述管状构件的远端的加强构件 ，所述加强构件包括至少两个细长线性构件，所述至少两个细长线性构件构造成将所述连接的管状和加强构件连接至心血管结构。
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公开(公告)号：EP2797556A1
公开(公告)日：2014-11-05
申请号：EP13861484.7
申请日：2013-03-01
发明人： MATHENY, Robert G.
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2436 , A61F2220/0016 , A61F2230/0095
摘要： Anchored cardiovascular valves having a support member with at least one leaflet formed therein that is sized and configured to selectively restrict regurgitating blood through the valve, and at least one anchoring mechanism. In a preferred embodiment of the invention, the anchored valves have two anchoring mechanisms, i.e. proximal and distal anchoring mechanisms
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公开(公告)号：EP3229731A1
公开(公告)日：2017-10-18
申请号：EP14907906.3
申请日：2014-12-12
发明人： MATHENY, Robert G.
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61K35/12 , A61K38/18 , A61L27/34 , A61L27/3633 , A61L27/507 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2400/16
摘要： The present invention is directed to vascular grafts for treating, reconstructing and replacing damaged or diseased cardiovascular vessels that are formed from decellularized extracellular matrix (ECM). The vascular grafts include outer or outer and inner coatings that provide structural reinforcement. In some embodiments, the tubular members comprise at1 ECM/ECM-mimicking biomaterial composition comprising an ECM material and an ECM-mimicking biomaterial, such as poly(glycerol sebacate) (PGS).
摘要翻译： 本发明涉及用于治疗，重建和替代由脱细胞胞外基质（ECM）形成的受损或患病心血管血管的血管移植物。 血管移植物包括提供结构增强的外部或外部和内部涂层。 在一些实施方案中，管状构件包含包含ECM材料和诸如聚（癸二酸甘油酯）（PGS）的ECM模拟生物材料的包含ECM / ECM的模拟生物材料组合物。
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8.发明公开ANISOTROPIC CONSTRUCTS AND METHODS FOR FORMING AND USING SAME FOR TREATING DAMAGED BIOLOGICAL TISSUE 审中-公开各向异性构造及其形成和使用方法以治疗受损生物组织
公开(公告)号：EP3229730A1
公开(公告)日：2017-10-18
申请号：EP15867329.3
申请日：2015-11-30
发明人： MATHENY, Robert G.
IPC分类号： A61F2/02
CPC分类号： A61L27/3633 , A61L27/54 , A61L27/58 , A61L2300/41 , A61L2300/64 , A61L2430/20
摘要： Anisotropic constructs having a base member with a defined surface that includes a plurality of substantially parallel equidistant linear channels that are configured to modulate the polarity and proliferation of cells through spatial and biomechanical cues. The constructs are also capable of administering a biologically active agent and/or a pharmacological composition to tissue.
摘要翻译： 具有基部构件的各向异性构造，所述基部构件具有限定的表面，所述限定的表面包括多个基本上平行的等距线性通道，所述多个基本平行的等距线性通道被配置为通过空间和生物力学线索调节细胞的极性和增殖。 该构建体还能够将生物活性剂和/或药理学组合物给予组织。
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公开(公告)号：EP2897624A1
公开(公告)日：2015-07-29
申请号：EP13839811.0
申请日：2013-06-15
发明人： MATHENY, Robert G.
IPC分类号： A61K35/12
CPC分类号： A61L27/3633 , A61B17/205 , A61B2017/00247 , A61K9/0019 , A61K31/165 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/4174 , A61K31/43 , A61K31/4418 , A61K31/47 , A61K31/505 , A61K31/65 , A61K31/7048 , A61K31/7056 , A61K31/722 , A61K35/34 , A61K35/38 , A61K38/14 , A61K45/06 , A61K48/00 , A61L27/367 , A61L27/3683 , A61L27/3873 , A61L2400/06 , A61L2430/20 , A61K2300/00
摘要： A composition for reconstruction, replacement or repair of damaged or diseased biological tissue comprising an extracellular matrix (ECM) composition that includes an ECM scaffold component derived from a mammalian source and at least one additional bioactive agent. In a preferred embodiment, the ECM scaffold component comprises mesothelial tissue and the bioactive agent component comprises an antibiotic.
摘要翻译： 用于重建，置换或修复受损或患病生物组织的组合物，其包含细胞外基质（ECM）组合物，其包含源自哺乳动物来源的ECM支架组分和至少一种另外的生物活性剂。 在一个优选实施方案中，ECM支架组分包含间皮组织并且生物活性剂组分包含抗生素。
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10.发明公开A DRUG ELUTING PATCH FOR THE TREATMENT OF LOCALIZED TISSUE DISEASE OR DEFECT 有权药物涂层的石膏局部组织疾病或组织缺损的治疗
公开(公告)号：EP2654714A1
公开(公告)日：2013-10-30
申请号：EP11806039.1
申请日：2011-12-09
发明人： MATHENY, Robert G.
IPC分类号： A61K9/00
CPC分类号： A61K9/0024 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/4418 , A61K31/47 , A61K31/505 , A61K45/06 , A61L17/005 , A61L24/0015 , A61L29/16 , A61L31/16 , A61L2300/434
摘要： A polymeric matrix for delivery of an HMG CoA reductase inhibitor such as a statin to tissue such as cardiac tissue in need thereof for the treatment or prevention of a disease or defect such as atrial fibrillation has been developed. In the preferred embodiment, a statin is delivered by means of a patch sutured to cardiac tissue at the time of cardiothoracic surgery. In the most preferred embodiment, the patch is a biodegradable material providing controlled or sustained release over a prolonged period of time, such as a week. Suitable materials include extracellular matrix, or other biodegradable hydrogels or polymeric materials providing sustained or controlled release of statin at the site of application.
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