公开(公告)号：EP0862418A1

公开(公告)日：1998-09-09

申请号：EP96937286.0

申请日：1996-10-30

申请人： SCHERING AKTIENGESELLSCHAFT

发明人： RÖSSLING, Georg ,  ALBAYRAK, Celál ,  TACK, Johannes ,  SCHMITZ, Reinhard

IPC分类号： A61K9 ,  A61K38 ,  B01J13

CPC分类号： A61K9/1647 ,  A61K9/5031 ,  A61K38/09 ,  A61K38/21 ,  A61K38/28 ,  A61K38/38 ,  B01J13/02 ,  Y10S514/937

摘要： The invention concerns a method of producing morphologically uniform microcapsules containing peptides, proteins or other water-soluble biologically active substances as active substance, and microcapsules produced by this method with a charging degree of between 3 and 30 wt.% and a diameter of ≤ 8 νm. According to the invention, biodegradable polymers are dissolved in a halogen-free solvent or solution mixture and the buffered active substance solution, which has a pH of between 6.0 and 8.0, is dispersed in this solution. An aqueous solution containing a surfactant is then added to this W/O emulsion (W/O/W emulsion) and the solvent removed. The microcapsules produced by this method display no tendency to agglomerate. The encapsulation efficiency of the method is between 90 and 95 %.

公开(公告)号：EP0567095B1

公开(公告)日：1996-07-03

申请号：EP93106469.5

申请日：1993-04-21

申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

发明人： Takahashi, Hiroshi ,  Umezaki, Hiroshi ,  Teshima, Yasushi

IPC分类号： C04B35/10

CPC分类号： C04B35/115

公开(公告)号：EP0560790A1

公开(公告)日：1993-09-22

申请号：EP91919331.0

申请日：1991-10-07

申请人： SUN CHEMICAL CORPORATION

发明人： KRISHNAN, Ramasamy ,  BASSEMIR, Robert, W. ,  VOGEL, Timothy

IPC分类号： C09D11

CPC分类号： C09D11/03

摘要： Compositions d'encre à base d'eau comprenant de l'eau, un pigment, un tensio-actif non-ionique présentant une solubilité dans l'eau inférieure à environ 0,5 % en poids et un agent de dissolution suffisant pour dissoudre pratiquement l'intégralité du tensio-actif non-ionique.

公开(公告)号：EP0532629A1

公开(公告)日：1993-03-24

申请号：EP91911167.0

申请日：1991-05-15

申请人： MERRELL DOW PHARMACEUTICALS INC.

发明人： CARR, Albert, A. ,  DAGE, Richard, C. ,  NIEDUZAK, Thaddeus, R. ,  KOERNER, John, E. ,  LI, Tung

IPC分类号： A61K31 ,  A61P9 ,  C07D211

CPC分类号： C07D211/32 ,  C07D211/22

摘要： On décrit une nouvelle classe d'alcanoylarylsulfonamides de pipéridinyle-1 ainsi que leur utilisation à titre d'agents antiarythmiques.

摘要翻译： 公开了一类新的哌啶基-1-链烷酰基芳基磺酰胺及其作为抗心律不齐药的用途。

公开(公告)号：EP0523555A1

公开(公告)日：1993-01-20

申请号：EP92111737.0

申请日：1992-07-10

申请人： KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA

发明人： Matsumoto, Hiroshi ,  Kondo, Kensuke ,  Inoue, Kazuhiko ,  Tani, Nobutaka

IPC分类号： A61L27/00 ,  A61L29/00 ,  A61L33/00 ,  A61K31/505

CPC分类号： A61L27/505 ,  A61K31/505 ,  A61L17/005 ,  A61L29/143 ,  A61L33/0041 ,  A61L2300/204 ,  A61L2300/42 ,  Y10S623/92

摘要： The invention relates to the preparation of a pharmaceutical composition useful in inhibiting decomposition and/or degradation of a polymeric implantation material in the living body, which comprises dipyridamole and/or a salt or a derivative thereof as an active component and a polymeric implantation material which contains dipyridamole and/or a salt or a derivative thereof as an active component.

摘要翻译： 本发明涉及的药物组合物的制备可用于抑制在活体的聚合物植入材料，其中其包含双嘧达莫和/或盐或衍生物作为活性组分和聚合物植入材料的分解和/或降解哪 包含双嘧达莫和/或其盐或它们的衍生物作为活性组分。

公开(公告)号：EP1296978A2

公开(公告)日：2003-04-02

申请号：EP01952369.5

申请日：2001-06-29

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： KO, Soo, S. ,  PRUITT, James, R. ,  WACKER, Dean, A. ,  BATT, Douglas, G.

IPC分类号： C07D403/12

CPC分类号： C07D413/14 ,  C07D211/56 ,  C07D211/58 ,  C07D211/60 ,  C07D211/62 ,  C07D211/96 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14 ,  C07D417/14

摘要： The present application describes modulators of CCR3 of formula (I): (I)or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.

公开(公告)号：EP0560790B1

公开(公告)日：1996-04-24

申请号：EP91919331.8

申请日：1991-10-07

申请人： SUN CHEMICAL CORPORATION

发明人： KRISHNAN, Ramasamy ,  BASSEMIR, Robert, W. ,  VOGEL, Timothy

IPC分类号： C09D11/02

CPC分类号： C09D11/03

摘要： Water-based ink compositions comprising water, a pigment, a nonionic surfactant having a solubility in water of less than about 0.5 wt. % and a solubilizing agent sufficient to solubilize substantially all of the nonionic surfactant.

公开(公告)号：EP0217258A2

公开(公告)日：1987-04-08

申请号：EP86113026.8

申请日：1986-09-22

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： Wurtman, Richard J. ,  Conlay, Lydia ,  Blusztajn, Krzyoztof

IPC分类号： A61K31/14 ,  A61K31/685

CPC分类号： A61K31/685

摘要： The use of choline or choline releasing compounds in the production of pharmacological compositions capable of reducing fatigue in a patient who has or is about to participate in major exercise by increasing acetylcholine levels in the brain or other tissues. The term "fatigue" as used herein means the subjective feeling of tiredness as well as the fatigue of muscles and the actual decrease of performance.

摘要翻译： 生产能够在病人谁拥有或即将由大脑或其他组织提高乙酰胆碱的水平参与重大演习减轻疲劳的药物组合物的使用胆碱或胆碱释放的化合物。 在指用于疲劳的主观感觉和肌肉的疲劳和业绩的实际下降的术语“疲劳”。

公开(公告)号：EP1006950B1

公开(公告)日：2004-04-07

申请号：EP97939677.7

申请日：1997-08-29

申请人： Verigen Transplantation Service International (VTSI) AG

发明人： VIBE-HANSEN, Henrik ,  LUNDSGAARD, Charlotte ,  IDOURAINE, Ahmed ,  OSTHER, Kurt, B.

IPC分类号： A61F2/30 ,  A61B17/326

CPC分类号： A61F2/2846 ,  A61B17/00491 ,  A61F2/30756 ,  A61F2/38 ,  A61F2002/2835 ,  A61F2002/30016 ,  A61F2002/30062 ,  A61F2002/30535 ,  A61F2002/30761 ,  A61F2002/30762 ,  A61F2210/0004 ,  A61F2250/0019 ,  A61F2250/0058 ,  A61F2310/00365 ,  A61L2430/06

摘要： Method for the effective transplantation of chondrocytes/cartilage to an articular joint surface defect is taught, as well as a description of certain instruments and kit for practicing the invention.

公开(公告)号：EP1173266A1

公开(公告)日：2002-01-23

申请号：EP00918671.9

申请日：2000-04-20

申请人： Koblizek, Jan

发明人： Koblizek, Jan

IPC分类号： B01D17/032 ,  E02B15/04 ,  B01D21/24

CPC分类号： B01D21/2433 ,  B01D17/0214 ,  B01D17/0217 ,  E02B15/107

摘要： For mechanical separation of not mixing liquids there is designed an equipment comprising the first vessel (1), the bottom (2) of which is inclined with respect to a horizontal level, the first vessel (1) having a liner (5) passing through the first vessel (1) and accommodating a hollow shaft (6) of a disk (7) located plan-parallel with the first vessel bottom outside surface, the disk (7) being provided with at least two spiral blades (8), which are arranged at the disk (7) surface remote to the vessel bottom (2) and defining chambers (9), each of the chambers (9) opening tangentially to the disk (7) and axially in a direction opposite to the disk position, and leading into one of channels (10) provided for by axial baffles (11) built within the hollow shaft (6), provided each of the channels (10), the number of which corresponds to the number of chambers (9), open by the first opening (12), passing through the hollow shaft (6) wall, into the liner (6) cavity, the jacket of which is furnished with a second opening (13).