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公开(公告)号：EP1656345A1
公开(公告)日：2006-05-17
申请号：EP04781806.7
申请日：2004-08-20
发明人： CARTER, Percy, H. , CHERNEY, Robert, J. , BATT, Douglas, G. , DUNCIA, John, V. , GARDNER, Daniel, S. , KO, Soo, S. , SRIVASTAVA, Anurag, S. , YANG, Michael, G.
IPC分类号： C07D207/26 , A61K31/4015
CPC分类号： C07D207/273 , C04B35/632 , C07D207/34 , C07D211/86 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/04
摘要： The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.
摘要翻译： 本申请描述了用于治疗类风湿性关节炎，多发性硬化，动脉粥样硬化和哮喘的式（I）的MCP-1或其药学上可接受的盐形式的调节剂。
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公开(公告)号：EP2326634A1
公开(公告)日：2011-06-01
申请号：EP09790360.3
申请日：2009-07-14
发明人： BATT, Douglas, G.
IPC分类号： C07D311/60 , C07D405/04 , C07D407/04 , A61P11/06 , A61P19/02 , A61P37/00 , A61K31/352
CPC分类号： C07D311/58 , C07D311/32 , C07D311/60 , C07D311/66 , C07D405/04 , C07D407/04
摘要： The present application describes modulators of MCP-1 or CCR-2 of formula (I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein W
1 , W
2 , W
3 , Y, Z, R
2 , R
3 , R
3 ' and R
4 , are defined in the specification. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.-
公开(公告)号：EP2326634B1
公开(公告)日：2014-11-05
申请号：EP09790360.3
申请日：2009-07-14
发明人： BATT, Douglas, G.
IPC分类号： C07D311/60 , C07D405/04 , C07D407/04 , A61P11/06 , A61P19/02 , A61P37/00 , A61K31/352
CPC分类号： C07D311/58 , C07D311/32 , C07D311/60 , C07D311/66 , C07D405/04 , C07D407/04
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4.发明公开
公开(公告)号：EP1656138A2
公开(公告)日：2006-05-17
申请号：EP04781805.9
申请日：2004-08-20
发明人： CARTER, Percy, H. , CHERNEY, Robert, J. , BATT, Douglas, G. , BROWN, Gregory, D. , DUNCIA, John, V. , GARDNER, Daniel, S. , YANG, Michael, G.
IPC分类号： A61K31/421 , A61K31/422 , C07D413/12
CPC分类号： C07C237/22 , C07B2200/07 , C07C275/42 , C07C2601/14 , C07D205/04 , C07D207/34 , C07D213/38 , C07D213/64 , C07D213/65 , C07D213/75 , C07D213/81 , C07D213/82 , C07D231/40 , C07D231/56 , C07D233/56 , C07D235/30 , C07D239/28 , C07D239/42 , C07D239/94 , C07D257/04 , C07D261/20 , C07D271/06 , C07D277/28 , C07D295/205 , C07D295/215 , C07D307/66 , C07D307/68 , C07D401/04 , C07D413/12 , C07D487/04
摘要： The present application describes modulators of MCP-1 of formula (I) or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.
摘要翻译： 本申请描述了可用于预防哮喘，多发性硬化，动脉粥样硬化和类风湿性关节炎的式（I）的MCP-1或其药学上可接受的盐形式的调节剂。
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5.发明授权CYCLOHEXENYL COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 有权趋化因子受体的CYCLOHEXENYLVERBINDUNGEN AS调节剂
公开(公告)号：EP2318352B1
公开(公告)日：2012-12-19
申请号：EP09790359.5
申请日：2009-07-14
发明人： CARTER, Percy, H. , BROWN, Gregory, D. , DE LUCCA, George, V. , BATT, Douglas, G. , LIU, Rui-Qin , QIU, Feng
IPC分类号： C07C61/15 , C07C61/28 , C07C61/39 , C07C61/40 , C07C62/32 , C07C62/34 , C07C233/47 , C07C311/51 , A61K31/18 , A61K31/192 , A61P19/02 , A61P9/12 , A61P11/06 , A61P31/18
CPC分类号： C07C311/51 , C07C61/40 , C07C62/34 , C07C233/47 , C07C2601/16
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公开(公告)号：EP2370407A1
公开(公告)日：2011-10-05
申请号：EP09793679.3
申请日：2009-12-17
发明人： PURANDARE, Ashok, Vinayak , BATT, Douglas, G. , LIU, Qingjie , JOHNSON, Walter, L. , MASTALERZ, Harold , ZHANG, Guifen , ZIMMERMANN, Kurt
IPC分类号： C07D209/88 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/02 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07D451/06 , A61P35/00 , A61K31/403
CPC分类号： C07D209/88 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07D451/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/08 , C07D487/14 , C07D491/08 , C07D491/113 , C07D493/10 , C07D498/08 , C07D519/00
摘要： The present invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) compounds inhibit tyrosine kinase activity of Jak2, thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.
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7.发明公开N-UREIDOALKYL-AMINO COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 审中-公开的N-脲基氨基的化合物作为趋化因子受体活性调节剂
公开(公告)号：EP1682105A2
公开(公告)日：2006-07-26
申请号：EP04810848.4
申请日：2004-11-13
发明人： KO, Soo, S. , BATT, Douglas, G. , DELUCCA, George, V. , DUNCIA, John, V. , GARDNER, Daniel, S. , SANTELLA, Joseph, B.
IPC分类号： A61K31/00
CPC分类号： A61K31/506 , A61K31/454 , A61K31/497 , A61K31/501 , C07C275/30 , C07C275/34 , C07C275/38 , C07C2601/02 , C07C2601/14 , C07D231/56 , C07D239/26 , C07D257/04 , C07D277/48 , C07D285/135 , C07D317/64 , C07D317/66 , C07D401/12 , C07D403/12
摘要： The present application describes modulators of chemokine receptors of formula (I), or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
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公开(公告)号：EP2370407B1
公开(公告)日：2014-06-18
申请号：EP09793679.3
申请日：2009-12-17
发明人： PURANDARE, Ashok, Vinayak , BATT, Douglas, G. , LIU, Qingjie , JOHNSON, Walter, L. , MASTALERZ, Harold , ZHANG, Guifen , ZIMMERMANN, Kurt
IPC分类号： C07D209/88 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/02 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07D451/06 , C07D487/08 , C07D491/113 , C07D493/10 , C07D498/08 , C07D519/00 , C07D491/08 , C07D487/14
CPC分类号： C07D209/88 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07D451/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/08 , C07D487/14 , C07D491/08 , C07D491/113 , C07D493/10 , C07D498/08 , C07D519/00
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公开(公告)号：EP1656345B1
公开(公告)日：2013-10-16
申请号：EP04781806.7
申请日：2004-08-20
发明人： CARTER, Percy, H. , CHERNEY, Robert, J. , BATT, Douglas, G. , DUNCIA, John, V. , GARDNER, Daniel, S. , KO, Soo, S. , SRIVASTAVA, Anurag, S. , YANG, Michael, G.
IPC分类号： C07D207/26 , A61K31/4015
CPC分类号： C07D207/273 , C04B35/632 , C07D207/34 , C07D211/86 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/04
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公开(公告)号：EP2318352A2
公开(公告)日：2011-05-11
申请号：EP09790359.5
申请日：2009-07-14
发明人： CARTER, Percy, H. , BROWN, Gregory, D. , DE LUCCA, George, V. , BATT, Douglas, G. , LIU, Rui-Qin , QIU, Feng
IPC分类号： C07C61/15 , C07C61/28 , C07C61/39 , C07C61/40 , C07C62/32 , C07C62/34 , C07C233/47 , C07C311/51 , A61K31/18 , A61K31/192 , A61P19/02 , A61P9/12 , A61P11/06 , A61P31/18
CPC分类号： C07C311/51 , C07C61/40 , C07C62/34 , C07C233/47 , C07C2601/16
摘要： The present application describes modulators of MCP-1 or CCR-2 of formula,(I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein T, W, X, Y, Z, R
1 , R
2 , R
4 and R
6 , are defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula, (I) are disclosed.摘要翻译： 本申请描述了式（I）的MCP-1或CCR-2或其立体异构体或前药或其药学上可接受的盐的调节剂，其中定义T，W，X，Y，Z，R 1，R 2，R 4和R 6 于此。 此外，公开了使用式（I）的调节剂治疗和预防炎性疾病如哮喘和过敏性疾病以及类风湿性关节炎和移植排斥的自身免疫病态的方法。
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