公开(公告)号：EP3071249B1

公开(公告)日：2018-08-29

申请号：EP14799831.4

申请日：2014-11-20

Applicant: DSM IP Assets B.V.

Inventor： BELT, Johannes Wilhelmus ,  GIJSMAN, Pieter

IPC: A61L29/08 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14

CPC classification number: A61L29/085 ,  A61B50/30 ,  A61L2/081 ,  A61L2/087 ,  A61L29/041 ,  A61L29/14 ,  A61L29/143 ,  A61L31/10 ,  A61L31/14 ,  A61L31/143 ,  A61L2300/428 ,  A61L2400/10 ,  A61L2420/02 ,  A61L2420/06 ,  B65B55/08 ,  B65B55/16 ,  B65D81/2069 ,  B65D81/266

Abstract: A method of reducing the deterioration of a wetted hydrophilic coating caused by sterilization by radiation is provided. The method comprises the step of incorporating a thiosulfate anion and a buffer into the wetting hydrophilic coating comprising water. Some embodiments of the invention relate to a wetted hydrophilic coating, a wetting agent, a package comprising a wetted hydrophilic coating, and a method of sterilizing a wetted hydrophilic coating.

公开(公告)号：EP3071249A1

公开(公告)日：2016-09-28

申请号：EP14799831.4

申请日：2014-11-20

Applicant: DSM IP Assets B.V.

Inventor： BELT, Johannes Wilhelmus ,  GIJSMAN, Pieter

IPC: A61L29/08 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14

CPC classification number: A61L29/085 ,  A61B50/30 ,  A61L2/081 ,  A61L2/087 ,  A61L29/041 ,  A61L29/14 ,  A61L29/143 ,  A61L31/10 ,  A61L31/14 ,  A61L31/143 ,  A61L2300/428 ,  A61L2400/10 ,  A61L2420/02 ,  A61L2420/06 ,  B65B55/08 ,  B65B55/16 ,  B65D81/2069 ,  B65D81/266

Abstract: A method of reducing the deterioration of a wetted hydrophilic coating caused by sterilization by radiation is provided. The method comprises the step of incorporating a thiosulfate anion and a buffer into the wetting hydrophilic coating comprising water. Some embodiments of the invention relate to a wetted hydrophilic coating, a wetting agent, a package comprising a wetted hydrophilic coating, and a method of sterilizing a wetted hydrophilic coating.

公开(公告)号：EP2886136A1

公开(公告)日：2015-06-24

申请号：EP15154222.2

申请日：2011-04-18

Applicant: AngioScore, Inc.

Inventor： Speck, Ulrich ,  Berg, Madeleine Caroline

IPC: A61L29/16 ,  A61L31/16

CPC classification number: A61L29/08 ,  A61B17/320725 ,  A61B2017/320733 ,  A61L29/143 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/802 ,  A61M25/10 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/109

Abstract: A catheter for angioplasty or coronary angioplasty of a vessel or tissue is described. The catheter includes a shaft having a proximal portion and a distal portion and a balloon is carried at the distal portion of the shaft. The catheter further includes wires having a profile that surrounds the balloon. A coating is carried on at least 50% of the surface of the balloon and comprises at least one drug or drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein a combination of limus drugs with butylated hydroxytoluene as the lipophilic antioxidant is excluded.

Abstract translation: 描述了用于血管或组织的血管成形术或冠状动脉血管成形术的导管。 导管包括具有近侧部分和远侧部分的轴，并且在该轴的远侧部分处携带球囊。 导管还包括具有围绕球囊的轮廓的线。 涂层在球囊表面的至少50％上进行并且包含至少一种药物或药物制剂和至少一种亲脂性抗氧化剂，其中所述亲脂性抗氧化剂的比例为所述至少一种亲脂性抗氧化剂的3-100重量％ 100重量％的药物，其中排除了作为亲脂性抗氧化剂的淡化药物与丁基化羟基甲苯的组合。

公开(公告)号：EP2813250A1

公开(公告)日：2014-12-17

申请号：EP13768084.9

申请日：2013-03-15

Applicant: Terumo Kabushiki Kaisha

Inventor： YAMASHITA Keiko ,  NOZAWA Shigenori

IPC: A61L29/00 ,  A61L31/00

CPC classification number: A61K31/337 ,  A61F2/93 ,  A61F2310/0097 ,  A61F2310/00976 ,  A61K47/10 ,  A61K47/183 ,  A61L29/08 ,  A61L29/085 ,  A61L29/143 ,  A61L29/16 ,  A61L31/08 ,  A61L31/10 ,  A61L31/143 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/06 ,  A61M25/10 ,  A61M2025/105 ,  C08L77/04

Abstract: The present invention provides a coating composition for drug-eluting medical devices, which enables a medical device to be delivered to a target tissue for the purpose of treating an affected blood vessel part such as restenosis, without easy separation of a drug from the medical device during the delivery process. This coating composition for drug-eluting medical devices contains a water-insoluble drug and at least one selected from the group consisting of ester compounds of amino acids, which have a hydrophobicity index of a side chain of an amino acid of zero or less than zero, and salts thereof.

公开(公告)号：EP2560697A1

公开(公告)日：2013-02-27

申请号：EP10775805.4

申请日：2010-11-03

Applicant: InnoRa Gmbh

Inventor： SPECK, Ulrich ,  BERG, Madeleine Caroline

IPC: A61L29/16 ,  A61L31/16

CPC classification number: A61L29/08 ,  A61B17/320725 ,  A61B2017/320733 ,  A61L29/143 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/802 ,  A61M25/10 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/109

Abstract: The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one drug or drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein a combination of the at least one drug being a limus drug and the at least one lipophilic antioxidant being butylated hydroxytoluene is excluded.

Abstract translation: 本发明涉及对至少在其一部分表面上携带至少一种药物或药物制剂和至少一种亲脂性抗氧化剂的球囊导管进行刻痕或切割，所述亲脂性抗氧化剂的比例为所述至少一种亲脂性抗氧化剂的3-100重量％ 相对于100重量％的药物，其中排除了至少一种作为limus药物的药物和作为丁基化羟基甲苯的至少一种亲脂性抗氧化剂的组合。

公开(公告)号：EP1596755A2

公开(公告)日：2005-11-23

申请号：EP04702484.9

申请日：2004-01-15

Applicant: Cambridge Polymer Group, Inc. ,  MASSACHUSETTS GENERAL HOSPITAL

Inventor： MURATOGLU, Orhun, K. ,  SPIEGELBERG, Stephen, H.

IPC: A61F2/00

CPC classification number: B29C35/0805 ,  A61L27/16 ,  A61L27/505 ,  A61L29/041 ,  A61L29/143 ,  A61L31/048 ,  A61L31/143 ,  B29C43/003 ,  C08J3/28 ,  C08K5/005 ,  C08K5/1545 ,  C08L23/06 ,  C08L2312/06 ,  Y10T29/49 ,  Y10T29/49995 ,  Y10T428/31855

Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.

公开(公告)号：EP0345662A1

公开(公告)日：1989-12-13

申请号：EP89110021.6

申请日：1989-06-02

Applicant: THE B.F. GOODRICH COMPANY

Inventor： Forsyth, Thomas Henry ,  Summers, James William ,  Toyoda, Paul Scott ,  Kline, Sally Ann ,  Rabinovitch, Elvira Borisovna

IPC: C08L27/06 ,  C08K5/00 ,  A61L2/08

CPC classification number: C08K5/13 ,  A61L29/143 ,  A61L31/143 ,  C08K5/11 ,  C08K5/57 ,  C08L27/06

Abstract: The present invention resides in a clear, rigid, vinyl polymer part sterilized by exposure to about 2 to about 5 Mrad of gamma radiation characterized as having an increase in yellowness index from radiation, as determined by ASTM D1925-70, of less than about 10, and a rigidity as determined by ASTM Tensile Test D638 of more than about 250,000 psi.

Abstract translation: 本发明在于通过暴露于约2至约5Mrad的γ辐射灭菌的透明，刚性的乙烯基聚合物部件，其特征在于根据ASTM D1925-70测定的辐射的黄度指数增加小于约10 ，并且由ASTM拉伸试验D638测定的刚度大于约250,000psi。

公开(公告)号：EP3281649A1

公开(公告)日：2018-02-14

申请号：EP16001766.1

申请日：2016-08-09

Applicant: Teleflex Lifesciences

Inventor： Kelly, Ronald John ,  Tierney, Morgan ,  Mcburney, Denzell

IPC: A61L27/34 ,  A61L27/50 ,  A61L27/52 ,  A61L29/08 ,  A61L29/14

CPC classification number: A61L29/085 ,  A61L2/10 ,  A61L27/34 ,  A61L27/50 ,  A61L27/505 ,  A61L27/52 ,  A61L29/14 ,  A61L29/143 ,  A61L29/145 ,  A61L2202/24 ,  A61L2400/10

Abstract: The present invention relates to a composition for preventing or retarding degradation of a functional coating on a medical device comprising an antioxidant selected from gallic acid or a derivative thereof, the use of the composition for preventing or retarding degradation of a functional coating on a medical device from reactive species generated during exposure of radiation, and a wetting agent comprising the composition. Furthermore, the wetting agent prevents or retards the hydrolytic degradation of the coating during the intended shelf-life of the wetted coated product.

Abstract translation: 本发明涉及一种用于防止或延缓医疗器械上功能性涂层降解的组合物，该组合物包含选自没食子酸或其衍生物的抗氧化剂，该组合物用于防止或延缓医疗器械上功能性涂层的降解 来自辐射曝光期间产生的反应性物质和包含该组合物的润湿剂。 此外，润湿剂在湿涂布产品的预期保存期限内防止或延迟涂层的水解降解。

公开(公告)号：EP2926856A1

公开(公告)日：2015-10-07

申请号：EP15161499.7

申请日：2015-03-27

Applicant: Moss, Gerald

Inventor： Moss, Gerald

IPC: A61M25/00 ,  A61J15/00

CPC classification number: A61J15/0003 ,  A61J15/0049 ,  A61J15/0073 ,  A61L29/041 ,  A61L29/143 ,  A61M5/007 ,  A61M25/0026 ,  A61M2025/0035

Abstract: A multi lumen gastrointestinal catheter is disclosed. The multi-lumen gastrointestinal catheter has a flexible partition separating a feeding and an aspiration channel. A third smaller inflation channel is positioned within the outside exterior wall at the site of the flexible partition to avoid kinking at the inflation channel site, without need to re-enforce the weakened wall.

Abstract translation: 公开了一种多腔胃肠导管。 多腔胃肠导管具有分隔进食和吸气通道的柔性隔板。 第三个较小的充气通道位于柔性隔板位置的外部外壁内，以避免在充气通道位置处扭结，而无需重新强化弱化壁。

公开(公告)号：EP2886137A1

公开(公告)日：2015-06-24

申请号：EP15154223.0

申请日：2010-11-03

Applicant: Angioscore Inc.

Inventor： Speck, Ulrich ,  Berg, Madeleine Caroline

IPC: A61L29/16 ,  A61L31/16

CPC classification number: A61L29/08 ,  A61B17/320725 ,  A61B2017/320733 ,  A61L29/143 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/802 ,  A61M25/10 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/109

Abstract: A balloon catheter for angioplasty and coronary angioplasty and a method for manufacturing the balloon catheter is disclosed. The balloon catheter includes a shaft having a proximal portion and a distal portion; a balloon carried at the distal portion of the shaft; and wires having a profile that surrounds the balloon. The balloon and the wires are polymer-free sequentially coated with at least one oxidation-insensitive drug and at least one lipophilic antioxidant such that the oxidation-insensitive drug and the antioxidant are not homogeneously mixed.

Abstract translation: 公开了一种用于血管成形术和冠状动脉血管成形术的球囊导管及其制造方法。 气囊导管包括具有近端部分和远端部分的轴; 承载在所述轴的远端部分的气球; 以及具有围绕气球的轮廓的线。 气球和电线是无聚合物的，其顺序地涂覆有至少一种不敏感的药物和至少一种亲脂性抗氧化剂，使得氧化不敏感药物和抗氧化剂不均匀混合。