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    METHOD FOR DIAGNOSING DOWN'S SYNDROME BY USING DOWN'S SYNDROME-SPECIFIC EPIGENETIC MARKER
    3.
    发明公开
    METHOD FOR DIAGNOSING DOWN'S SYNDROME BY USING DOWN'S SYNDROME-SPECIFIC EPIGENETIC MARKER 审中-公开

    公开(公告)号：EP4177355A1

    公开(公告)日：2023-05-10

    申请号：EP21834599.9

    申请日：2021-05-07

    申请人： Sungkwang Medical Foundation

    发明人： RYU, Hyun Mee ,  LIM, Ji Hyae

    IPC分类号： C12Q1/6883

    摘要： Provided are a method of providing information for diagnosing Down syndrome and a method of diagnosing Down syndrome, the method comprising measuring a methylation level of a Down syndrome biomarker in a biological sample separated from a fetus, comparing the measured methylation level of the biomarker with a methylation level of the first biomarker and the second biomarker in the biological sample separated from a normal control group, and determining a presence or a risk of Down syndrome by comparing the methylation level, wherein the biomarker is a first biomarker present on chromosome 21, a second biomarker present on a chromosome other than chromosome 21, or a combination thereof. Thus, Down syndrome can be diagnosed early with high accuracy, and the disclosure is expected to be applied as a key technology in the field of Down syndrome diagnosis.

    EPIGENETIC BIOMARKER COMPOSITION FOR DIAGNOSING DOWN SYNDROME, AND USE THEREOF
    4.
    发明公开
    EPIGENETIC BIOMARKER COMPOSITION FOR DIAGNOSING DOWN SYNDROME, AND USE THEREOF 审中-公开

    公开(公告)号：EP4177354A1

    公开(公告)日：2023-05-10

    申请号：EP21832194.1

    申请日：2021-05-07

    申请人： Sungkwang Medical Foundation

    发明人： RYU, Hyun Mee ,  LIM, Ji Hyae

    IPC分类号： C12Q1/6883

    摘要： Provided are a composition for diagnosing Down syndrome, a kit including the composition, a diagnostic method, and a method of providing information for diagnosing Down syndrome, the composition including an agent for measuring a methylation level of any one gene selected from the group consisting of MXRA8, MIB2, KIF26B, SP5, ZIC4, ENPEP, PITX2, SH3BP2, SEPP1, FLJ32255, SHROOM1, LINC00574, LOC154449, PRRT4, TMEM176B, MNX1, LOC101928483, EGFL7, NACC2, C9orf69, TLX1, FGF8, TACC2, CPXM2, NKX6-2, TLX1NB, IQSEC3, PCDH8, F7, SOX9, PNMAL2, THBD, MAPK8IP2, KLHDC7B, GPR143, IGHMBP2, MRGPRD, CHODL, NCAM2, CYYR1, GRIK1, OLIG2, CLIC6, SIM2, HLCS, MX2, MX1, TMPRSS2, SLC37A1, PDE9A, CBS, CRYAA, C21orf2, TRPM2, TSPEAR, LINC00162, SSR4P1, SLC19A1, LOC100129027, MCM3AP, YBEY, PRMT2, and ITSN1. Thus, Down syndrome can be diagnosed early with high accuracy, and the disclosure is expected to be applied as key a technology in the field of Down syndrome diagnosis.

    STEREO SOUND BOX AND STEREO SOUND SYSTEM
    8.
    发明公开
    STEREO SOUND BOX AND STEREO SOUND SYSTEM 审中-公开

    公开(公告)号：EP4047951A1

    公开(公告)日：2022-08-24

    申请号：EP20877231.9

    申请日：2020-10-11

    申请人： TGI Technology Pte Ltd ,  Li, Shihuang

    发明人： LI, Shihuang

    IPC分类号： H04R5/02 ,  H04R3/12 ,  H04S1/00

    摘要： Provided in the present invention is a stereo sound box, including: a box body. Two sets of sound generating units are provided on a surface of the box body, correspondingly for a left sound channel and a right sound channel. Each set of sound generating units includes a low sound unit and at least one high sound unit. The low sound units of the two sets of sound generating units are arranged to mirror each other so as to neutralize the inertia of vibrations. The high sound units are arranged outside each low sound unit. In the described stereo sound box, high-fidelity low sound can be maintained even while the box body is kept light.